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• W3197349310 abstract "Abstract The silver fox and blue fox are economically important fur species and were domesticated by humans from their wild counterparts, the arctic fox and red fox, respectively. Farmed foxes show obvious differences from their wild counterparts, including differences in physiology, body size, energy metabolism, and immunity. However, the molecular mechanisms underlying these differences are presently unclear. In this study, we built transcriptome libraries from multiple pooled tissues for each species of farmed fox, used RNA‐seq to obtain a comprehensive dataset, and performed selection analysis and sequence‐level analyses of orthologous genes to identify the genes that may be influenced by human domestication. More than 153.3, 248.0, 81.6, and 65.8 million clean reads were obtained and assembled into a total of 118,577, 401,520, 79,900, and 186,988 unigenes with an average length range from 521 to 667 bp for AF, BF, RF, and SF, respectively. Selective pressure analysis showed that 11 and 14 positively selected genes were identified, respectively, in the two groups (AF vs. BF and RF vs. SF). Several of these genes were associated with natural immunity ( CFI and LRRFIP1 ), protein synthesis ( GOLGA4 , CEP19 and SLC35A2 ), and DNA damage repair ( MDC1 ). Further functional enrichment analyses demonstrated that two positively selected genes ( ACO1 and ACAD10 ) were involved in metabolic process (GO:0008152, p ‐value = .032), representing a significant enrichment. Sequence analysis of 117 orthologous genes shared by the two groups showed that the LEMD2 , RRBP1, and IGBP1 genes might be affected by artificial selection in farmed foxes, with mutation sites located within sequences that are otherwise highly conserved across most mammals. Our results provide a valuable transcriptomic resource for future genetic studies and improvement in the assisted breeding of foxes and other farmed animals." @default.
• W3197349310 created "2021-09-13" @default.
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• W3197349310 date "2021-08-30" @default.
• W3197349310 modified "2023-10-17" @default.
• W3197349310 title "Comparative transcriptome provides insights into the selection adaptation between wild and farmed foxes" @default.
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• W3197349310 doi "https://doi.org/10.1002/ece3.8071" @default.
• W3197349310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8495804" @default.
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• W3197349310 hasPublicationYear "2021" @default.
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