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- W3197352855 abstract "Epithelial to Mesenchymal Transition (EMT) is an evolutionarily conserved developmental program that confers metastatic properties to cancer cells through the transformation of cells from the nonmotile and polarised epithelial state to a motile, nonpolarised mesenchymal state. EMT can impart higher invasion, stemness, and drug resistance to tumor cells and is usually involved in cancer cell dissemination. Its reverse—Mesenchymal to Epithelial Transition (MET) is often implicated in colonization—the last step of the metastatic cascade. Though several mechanisms of EMT induction and their phenotypic outcomes are well established, the dynamic reprogramming of the epigenome during EMT and/or MET and their influence on metastasis and drug resistance remains to be explored. This chapter will address several layers of epigenetic mechanisms such as DNA methylation, histone modifications, and their cross-talk that govern EMT and/or MET processes. The histone code regulating the activity of various EMT-associated transcription factors such as ZEB1, SNAIL, SLUG, TWIST1, and various MET-associated transcription factors such as GRHL2, as well as genome and epigenome-wide studies that have captured epigenetic signaling during EMT, would be presented. The rewiring of the epigenome during metabolic reprogramming and consequent EMT induction would be reviewed. The chapter will also highlight the role of epigenetic rewiring in mediating the reversibility (or lack thereof, i.e., irreversibility) of EMT/MET and the consequences of such changes during metastasis." @default.
- W3197352855 created "2021-09-13" @default.
- W3197352855 creator A5001038154 @default.
- W3197352855 creator A5079959887 @default.
- W3197352855 creator A5080975571 @default.
- W3197352855 creator A5083772852 @default.
- W3197352855 date "2021-01-01" @default.
- W3197352855 modified "2023-09-26" @default.
- W3197352855 title "Epigenetics of epithelial to mesenchymal transition (EMT) in cancer" @default.
- W3197352855 cites W1491743000 @default.
- W3197352855 cites W1575147957 @default.
- W3197352855 cites W1963501822 @default.
- W3197352855 cites W1964314383 @default.
- W3197352855 cites W1964847767 @default.
- W3197352855 cites W1968791085 @default.
- W3197352855 cites W1974720903 @default.
- W3197352855 cites W1974812715 @default.
- W3197352855 cites W1977090021 @default.
- W3197352855 cites W1977970508 @default.
- W3197352855 cites W1987095400 @default.
- W3197352855 cites W1990895545 @default.
- W3197352855 cites W1995394695 @default.
- W3197352855 cites W2001653133 @default.
- W3197352855 cites W2010338855 @default.
- W3197352855 cites W2017729871 @default.
- W3197352855 cites W2024315189 @default.
- W3197352855 cites W2025647419 @default.
- W3197352855 cites W2026988350 @default.
- W3197352855 cites W2027998379 @default.
- W3197352855 cites W2029409898 @default.
- W3197352855 cites W2031941215 @default.
- W3197352855 cites W2035255090 @default.
- W3197352855 cites W2037583144 @default.
- W3197352855 cites W2037694089 @default.
- W3197352855 cites W2041806739 @default.
- W3197352855 cites W2043516790 @default.
- W3197352855 cites W2043797012 @default.
- W3197352855 cites W2045295282 @default.
- W3197352855 cites W2051846980 @default.
- W3197352855 cites W2054988060 @default.
- W3197352855 cites W2066092045 @default.
- W3197352855 cites W2066441178 @default.
- W3197352855 cites W2068087430 @default.
- W3197352855 cites W2068499430 @default.
- W3197352855 cites W2069266255 @default.
- W3197352855 cites W2072488296 @default.
- W3197352855 cites W2076225033 @default.
- W3197352855 cites W2080452140 @default.
- W3197352855 cites W2083399392 @default.
- W3197352855 cites W2087280324 @default.
- W3197352855 cites W2093965955 @default.
- W3197352855 cites W2096331437 @default.
- W3197352855 cites W2096762960 @default.
- W3197352855 cites W2102424043 @default.
- W3197352855 cites W2105156994 @default.
- W3197352855 cites W2105599008 @default.
- W3197352855 cites W2111183194 @default.
- W3197352855 cites W2112666597 @default.
- W3197352855 cites W2117247812 @default.
- W3197352855 cites W2120184946 @default.
- W3197352855 cites W2121624265 @default.
- W3197352855 cites W2122483745 @default.
- W3197352855 cites W2124803006 @default.
- W3197352855 cites W2125120607 @default.
- W3197352855 cites W2127217749 @default.
- W3197352855 cites W2129910915 @default.
- W3197352855 cites W2130503287 @default.
- W3197352855 cites W2131071584 @default.
- W3197352855 cites W2132566055 @default.
- W3197352855 cites W2134361367 @default.
- W3197352855 cites W2139241071 @default.
- W3197352855 cites W2141542227 @default.
- W3197352855 cites W2147464405 @default.
- W3197352855 cites W2150416393 @default.
- W3197352855 cites W2155131748 @default.
- W3197352855 cites W2160167196 @default.
- W3197352855 cites W2160641961 @default.
- W3197352855 cites W2170335587 @default.
- W3197352855 cites W2172286207 @default.
- W3197352855 cites W2181034117 @default.
- W3197352855 cites W2203257265 @default.
- W3197352855 cites W2223535266 @default.
- W3197352855 cites W2286869347 @default.
- W3197352855 cites W2408778670 @default.
- W3197352855 cites W2412680253 @default.
- W3197352855 cites W2460906374 @default.
- W3197352855 cites W2487275113 @default.
- W3197352855 cites W2504182378 @default.
- W3197352855 cites W2554348994 @default.
- W3197352855 cites W2567358926 @default.
- W3197352855 cites W2584776413 @default.
- W3197352855 cites W2587840780 @default.
- W3197352855 cites W2590805607 @default.
- W3197352855 cites W2730718150 @default.
- W3197352855 cites W2744585682 @default.
- W3197352855 cites W2746191482 @default.
- W3197352855 cites W2748976505 @default.
- W3197352855 cites W2751600998 @default.