Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197353363> ?p ?o ?g. }
- W3197353363 abstract "The rapid and widespread evolution of fungicide resistance remains a challenge for crop disease management. The demethylation inhibitor (DMI) class of fungicides is a widely used chemistry for managing disease, but there has been a gradual decline in efficacy in many crop pathosystems. Reliance on DMI fungicides has increased resistance in populations of the plant pathogenic fungus Cercospora beticola worldwide. To better understand the genetic and evolutionary basis for DMI resistance in C. beticola, a genome-wide association study (GWAS) and selective sweep analysis were conducted for the first time in this species. We performed whole-genome resequencing of 190 C. beticola isolates infecting sugar beet (Beta vulgaris ssp. vulgaris). All isolates were phenotyped for sensitivity to the DMI tetraconazole. Intragenic markers on chromosomes 1, 4, and 9 were significantly associated with DMI fungicide resistance, including a polyketide synthase gene and the gene encoding the DMI target CbCYP51. Haplotype analysis of CbCYP51 identified a synonymous mutation (E170) and nonsynonymous mutations (L144F, I387M, and Y464S) associated with DMI resistance. Genome-wide scans of selection showed that several of the GWAS mutations for fungicide resistance resided in regions that have recently undergone a selective sweep. Using radial plate growth on selected media as a fitness proxy, we did not find a trade-off associated with DMI fungicide resistance. Taken together, we show that population genomic data from a crop pathogen can allow the identification of mutations conferring fungicide resistance and inform about their origins in the pathogen population." @default.
- W3197353363 created "2021-09-13" @default.
- W3197353363 creator A5003997063 @default.
- W3197353363 creator A5005847037 @default.
- W3197353363 creator A5009416435 @default.
- W3197353363 creator A5010952009 @default.
- W3197353363 creator A5016555620 @default.
- W3197353363 creator A5016936972 @default.
- W3197353363 creator A5017845821 @default.
- W3197353363 creator A5032177921 @default.
- W3197353363 creator A5036531399 @default.
- W3197353363 creator A5040209675 @default.
- W3197353363 creator A5043731130 @default.
- W3197353363 creator A5061307460 @default.
- W3197353363 creator A5090777811 @default.
- W3197353363 date "2021-09-01" @default.
- W3197353363 modified "2023-10-02" @default.
- W3197353363 title "Genome-Wide Association and Selective Sweep Studies Reveal the Complex Genetic Architecture of DMI Fungicide Resistance in <i>Cercospora beticola</i>" @default.
- W3197353363 cites W102715436 @default.
- W3197353363 cites W1548439859 @default.
- W3197353363 cites W1593377767 @default.
- W3197353363 cites W1792060583 @default.
- W3197353363 cites W1842924979 @default.
- W3197353363 cites W1956613997 @default.
- W3197353363 cites W1979771317 @default.
- W3197353363 cites W1985190582 @default.
- W3197353363 cites W1987934716 @default.
- W3197353363 cites W1990074132 @default.
- W3197353363 cites W1990275569 @default.
- W3197353363 cites W1990621121 @default.
- W3197353363 cites W1993998094 @default.
- W3197353363 cites W1999403012 @default.
- W3197353363 cites W2013257834 @default.
- W3197353363 cites W2016776135 @default.
- W3197353363 cites W2021723562 @default.
- W3197353363 cites W2023176738 @default.
- W3197353363 cites W2035155292 @default.
- W3197353363 cites W2038157212 @default.
- W3197353363 cites W2042982067 @default.
- W3197353363 cites W2044035848 @default.
- W3197353363 cites W2055290765 @default.
- W3197353363 cites W2059570038 @default.
- W3197353363 cites W2073344396 @default.
- W3197353363 cites W2077199897 @default.
- W3197353363 cites W2082257506 @default.
- W3197353363 cites W2082607332 @default.
- W3197353363 cites W2088551831 @default.
- W3197353363 cites W2091101839 @default.
- W3197353363 cites W2094489008 @default.
- W3197353363 cites W2099085143 @default.
- W3197353363 cites W2099159297 @default.
- W3197353363 cites W2102951980 @default.
- W3197353363 cites W2104704034 @default.
- W3197353363 cites W2106397195 @default.
- W3197353363 cites W2106578986 @default.
- W3197353363 cites W2107266240 @default.
- W3197353363 cites W2108234281 @default.
- W3197353363 cites W2109195195 @default.
- W3197353363 cites W2110035718 @default.
- W3197353363 cites W2115319503 @default.
- W3197353363 cites W2119180969 @default.
- W3197353363 cites W2119452934 @default.
- W3197353363 cites W2126809009 @default.
- W3197353363 cites W2130092453 @default.
- W3197353363 cites W2131271579 @default.
- W3197353363 cites W2132960741 @default.
- W3197353363 cites W2133473785 @default.
- W3197353363 cites W2134057221 @default.
- W3197353363 cites W2134599124 @default.
- W3197353363 cites W2136411460 @default.
- W3197353363 cites W2147757952 @default.
- W3197353363 cites W2149992227 @default.
- W3197353363 cites W2153057813 @default.
- W3197353363 cites W2155670634 @default.
- W3197353363 cites W2157539385 @default.
- W3197353363 cites W2158978828 @default.
- W3197353363 cites W2159267650 @default.
- W3197353363 cites W2160397135 @default.
- W3197353363 cites W2162171804 @default.
- W3197353363 cites W2168460688 @default.
- W3197353363 cites W2183449495 @default.
- W3197353363 cites W2238981224 @default.
- W3197353363 cites W2258928300 @default.
- W3197353363 cites W2295348719 @default.
- W3197353363 cites W2343638431 @default.
- W3197353363 cites W2419589673 @default.
- W3197353363 cites W2464802198 @default.
- W3197353363 cites W2500922562 @default.
- W3197353363 cites W2513530705 @default.
- W3197353363 cites W2524169008 @default.
- W3197353363 cites W2524742846 @default.
- W3197353363 cites W2550355336 @default.
- W3197353363 cites W2555809179 @default.
- W3197353363 cites W2568344023 @default.
- W3197353363 cites W2580023202 @default.
- W3197353363 cites W2611528628 @default.
- W3197353363 cites W276354456 @default.
- W3197353363 cites W2793389063 @default.
- W3197353363 cites W2804572516 @default.
- W3197353363 cites W2805722463 @default.