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• W3197364175 abstract "Acute kidney injury (AKI) with high mortality rates is associated with an excess of reactive oxygen/nitrogen species (RONS) within kidney tissues. Recently, nanomedicine antioxidant therapy has been used to alleviate AKI. Herein, we synthesized ultrasmall Prussian blue nanozymes (PB NZs, 4.5 nm) as theranostic agents for magnetic resonance (MR)/photoacoustic (PA) dual-modal imaging guided AKI treatment.PB NZs exhibited multi-enzyme mimetic abilities, promoting the effective elimination of RONS both in vitro and in vivo. Moreover, benefiting from their imaging contrast properties, the rapid renal accumulation of PB NZs was verified by in vivo PA/MR dual-modal imaging. Due to their excellent enrichment in the kidney and unique multi-enzyme mimetic abilities, ultrasmall PB NZs displayed superior AKI treatment efficacy compared with that of amifostine in two clinically relevant types of AKI induced murine models (either by rhabdomyolysis or cisplatin).Our findings suggested ultrasmall PB NZs, as nanozyme theranostics, have great potential for AKI management." @default.
• W3197364175 created "2021-09-13" @default.
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• W3197364175 date "2021-09-06" @default.
• W3197364175 modified "2023-10-13" @default.
• W3197364175 title "Prussian blue-based theranostics for ameliorating acute kidney injury" @default.
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• W3197364175 doi "https://doi.org/10.1186/s12951-021-01006-z" @default.
• W3197364175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8419910" @default.
• W3197364175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34488789" @default.
• W3197364175 hasPublicationYear "2021" @default.
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