FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197382693> ?p ?o ?g. }

• W3197382693 endingPage "105035" @default.
• W3197382693 startingPage "105035" @default.
• W3197382693 abstract "Women who do not breastfeed or discontinue breastfeeding early are more likely to develop postpartum depression (PPD) and stress is a significant risk factor for depression, including PPD. Using a rat model, we investigated whether the absence of nursing would increase the susceptibility to chronic stress-related behavioral and neural changes during the postpartum period. Adult female rats underwent thelectomy (thel; removal of teats), sham surgery, or no surgery (control) and were paired with males for breeding. All litters were rotated twice daily until postpartum day (PD) 26. Sham rats served as surrogates for thel litters, yielding a higher nursing demand for sham rats. Concurrently, rats received either no stress or chronic variable stress until PD 25. Rats were observed for maternal behaviors and tested in a series of tasks including open field, sucrose preference, and forced swim. We used immunohistochemistry (IHC) for doublecortin (DCX; to label immature neurons) or for mineralocorticoid receptor (MR). Contrary to our expectations, non-nursing thel rats were resistant to the effects of stress in all dependent measures. Our data indicate that even in chronic adverse conditions, nursing is not required for maintaining stable care to offspring or active coping responses in an acutely stressful task. We discuss the possible role of offspring contact and consider future directions for biomedical and clinical research. In rats with high nursing demand, however, chronic stress increased immobility, hippocampal neurogenesis, and MR expression (largely in opposition to the effects of stress in rats with typical nursing demand). We discuss these patterns in the context of energetics and allostatic load. This research highlights the complexity in relationships between stress, nursing, and neurobehavioral outcomes in the postpartum period and underscores the need for additional biomedical and clinical research geared toward optimizing treatments and interventions for women with PPD, regardless of breastfeeding status. SIGNIFICANCE STATEMENT: The goal of this research was to determine how the absence of nursing and higher nursing demand impact stress-coping behaviors and neural changes associated with chronic stress in order to disentangle the complex interplay of factors that contribute to psychological illness during the postpartum period." @default.
• W3197382693 created "2021-09-13" @default.
• W3197382693 creator A5027511446 @default.
• W3197382693 creator A5061053910 @default.
• W3197382693 creator A5084028456 @default.
• W3197382693 date "2021-11-01" @default.
• W3197382693 modified "2023-09-27" @default.
• W3197382693 title "Lactation is not required for maintaining maternal care and active coping responses in chronically stressed postpartum rats: Interactions between nursing demand and chronic variable stress" @default.
• W3197382693 cites W1543985160 @default.
• W3197382693 cites W155479038 @default.
• W3197382693 cites W1849768371 @default.
• W3197382693 cites W1866674963 @default.
• W3197382693 cites W1904677686 @default.
• W3197382693 cites W1917336488 @default.
• W3197382693 cites W1966757737 @default.
• W3197382693 cites W1973250387 @default.
• W3197382693 cites W1975285965 @default.
• W3197382693 cites W1977410909 @default.
• W3197382693 cites W1979000630 @default.
• W3197382693 cites W1982238228 @default.
• W3197382693 cites W1985313383 @default.
• W3197382693 cites W1986249790 @default.
• W3197382693 cites W1988070297 @default.
• W3197382693 cites W1988080481 @default.
• W3197382693 cites W1990630984 @default.
• W3197382693 cites W1991131376 @default.
• W3197382693 cites W2000991114 @default.
• W3197382693 cites W2002129401 @default.
• W3197382693 cites W2004839259 @default.
• W3197382693 cites W2007232658 @default.
• W3197382693 cites W2009315995 @default.
• W3197382693 cites W2011670043 @default.
• W3197382693 cites W2013598219 @default.
• W3197382693 cites W2014559245 @default.
• W3197382693 cites W2016646130 @default.
• W3197382693 cites W2019513559 @default.
• W3197382693 cites W2020083105 @default.
• W3197382693 cites W2020232631 @default.
• W3197382693 cites W2021033832 @default.
• W3197382693 cites W2023343492 @default.
• W3197382693 cites W2027953236 @default.
• W3197382693 cites W2028124909 @default.
• W3197382693 cites W2035696194 @default.
• W3197382693 cites W2045355579 @default.
• W3197382693 cites W2045485656 @default.
• W3197382693 cites W2046563865 @default.
• W3197382693 cites W2047240739 @default.
• W3197382693 cites W2047465101 @default.
• W3197382693 cites W2049681707 @default.
• W3197382693 cites W2051005796 @default.
• W3197382693 cites W2056210458 @default.
• W3197382693 cites W2056853885 @default.
• W3197382693 cites W2059555201 @default.
• W3197382693 cites W2062973359 @default.
• W3197382693 cites W2063160971 @default.
• W3197382693 cites W2064209400 @default.
• W3197382693 cites W2064424963 @default.
• W3197382693 cites W2075407900 @default.
• W3197382693 cites W2079800537 @default.
• W3197382693 cites W2086787737 @default.
• W3197382693 cites W2088366321 @default.
• W3197382693 cites W2089372771 @default.
• W3197382693 cites W2091704323 @default.
• W3197382693 cites W2094125301 @default.
• W3197382693 cites W2097715719 @default.
• W3197382693 cites W2103166950 @default.
• W3197382693 cites W2105031370 @default.
• W3197382693 cites W2105203396 @default.
• W3197382693 cites W2109201315 @default.
• W3197382693 cites W2109202227 @default.
• W3197382693 cites W2109965039 @default.
• W3197382693 cites W2114419044 @default.
• W3197382693 cites W211815566 @default.
• W3197382693 cites W2119731148 @default.
• W3197382693 cites W2130281345 @default.
• W3197382693 cites W2135676659 @default.
• W3197382693 cites W2136704887 @default.
• W3197382693 cites W2137279928 @default.
• W3197382693 cites W2140683271 @default.
• W3197382693 cites W2142684707 @default.
• W3197382693 cites W2144101679 @default.
• W3197382693 cites W2145168172 @default.
• W3197382693 cites W2148592698 @default.
• W3197382693 cites W2155830392 @default.
• W3197382693 cites W2157345124 @default.
• W3197382693 cites W2162592296 @default.
• W3197382693 cites W2163583935 @default.
• W3197382693 cites W2166623778 @default.
• W3197382693 cites W2167279371 @default.
• W3197382693 cites W2167465800 @default.
• W3197382693 cites W2168493303 @default.
• W3197382693 cites W2170541972 @default.
• W3197382693 cites W2171007017 @default.
• W3197382693 cites W2177285566 @default.
• W3197382693 cites W2275332195 @default.
• W3197382693 cites W2285198650 @default.
• W3197382693 cites W2305661791 @default.
• W3197382693 cites W2325341530 @default.

• next