FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197400078> ?p ?o ?g. }

• W3197400078 endingPage "120336" @default.
• W3197400078 startingPage "120336" @default.
• W3197400078 abstract "New precise, responsive and selective univariate and multivariate chemometric spectrophotometric methods were developed and validated for determination of vandetanib (VTB), dasatinib (DTB), and sorafenib (SFB) in pure form, tablets, spiked human (plasma and urine). Determination of these drugs is essential because of their therapeutic benefits. These methods included double divisor ratio spectra derivative univariate method and chemometric multivariate method including partial least-squares (PLS) and principal component regression (PCR). A novel univariate method was developed for the estimation of these drugs. This method depends on the UV-Spectrophotometric data for simultaneous analysis of a ternary overlapped mixture. The Double divisor ratio spectra derivative absorption minima at 358.4 nm was used for quantification of VTB, absorption maxima at 300.3 nm for quantification of DTB and absorption maxima at 259.8 nm for quantification of SFB. This method shown a linearity in the extent of 2-9 μg/mL for VTB and DTB and over the concentration range of 3-9 μg/mL SFB within correlation coefficient (r2) of 0.9999. This method was successfully applied to pure form, tablet dosage form, spiked human (urine and plasma). Chemometric PLS and PCR models were found to be linear in the range of 2-9, 2-9, and 3-9 μg/mL for VTB, DTB and SFB, respectively. These models were estimated using eighteen mixtures as calibration set and seven mixtures as validation set. In the original data, the minimum root mean square error of prediction (RMSEP) was 0.11, 0.09 and 0.09 for VTB, DTB and SFB by PLS and 0.05, 0.04 and 0.03 by PCR while in the derivative data, the RMSEP was 0.09, 0.10 and 0.09 by PLS and 0.06, 0.06 and 0.03, by PCR for VTB, DTB and SFB, respectively. These methods were applied for the determination of the drugs in pure form and dosage form. Updating PLS model permitted the determination of the VTB, DTB and SFB in spiked human urine, plasma and drug-dissolution test of their tablet." @default.
• W3197400078 created "2021-09-13" @default.
• W3197400078 creator A5017902843 @default.
• W3197400078 creator A5041832558 @default.
• W3197400078 creator A5061560498 @default.
• W3197400078 creator A5075008176 @default.
• W3197400078 creator A5080398549 @default.
• W3197400078 creator A5082016889 @default.
• W3197400078 date "2022-01-01" @default.
• W3197400078 modified "2023-10-18" @default.
• W3197400078 title "Development of novel univariate and multivariate validated chemometric methods for the analysis of dasatinib, sorafenib, and vandetanib in pure form, dosage forms and biological fluids" @default.
• W3197400078 cites W1963616402 @default.
• W3197400078 cites W1970779231 @default.
• W3197400078 cites W1976202846 @default.
• W3197400078 cites W1979107490 @default.
• W3197400078 cites W1979477988 @default.
• W3197400078 cites W1985320798 @default.
• W3197400078 cites W1985495750 @default.
• W3197400078 cites W1988586881 @default.
• W3197400078 cites W1995293048 @default.
• W3197400078 cites W1997097814 @default.
• W3197400078 cites W2009814300 @default.
• W3197400078 cites W2014563113 @default.
• W3197400078 cites W2022286388 @default.
• W3197400078 cites W2030344285 @default.
• W3197400078 cites W2030485392 @default.
• W3197400078 cites W2048513746 @default.
• W3197400078 cites W2057627287 @default.
• W3197400078 cites W2061345986 @default.
• W3197400078 cites W2063900061 @default.
• W3197400078 cites W2074501693 @default.
• W3197400078 cites W2076479050 @default.
• W3197400078 cites W2079127064 @default.
• W3197400078 cites W2084220571 @default.
• W3197400078 cites W2084642759 @default.
• W3197400078 cites W2087624447 @default.
• W3197400078 cites W2088032513 @default.
• W3197400078 cites W2092606584 @default.
• W3197400078 cites W2101635775 @default.
• W3197400078 cites W2115817675 @default.
• W3197400078 cites W2158863190 @default.
• W3197400078 cites W2161643380 @default.
• W3197400078 cites W2168285637 @default.
• W3197400078 cites W2217442075 @default.
• W3197400078 cites W2490054713 @default.
• W3197400078 cites W2556782377 @default.
• W3197400078 cites W2580130954 @default.
• W3197400078 cites W2619134568 @default.
• W3197400078 cites W2657176750 @default.
• W3197400078 cites W2829029541 @default.
• W3197400078 cites W2892476255 @default.
• W3197400078 cites W2931319395 @default.
• W3197400078 cites W2948895606 @default.
• W3197400078 cites W2984767608 @default.
• W3197400078 cites W4246914745 @default.
• W3197400078 doi "https://doi.org/10.1016/j.saa.2021.120336" @default.
• W3197400078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34481256" @default.
• W3197400078 hasPublicationYear "2022" @default.
• W3197400078 type Work @default.
• W3197400078 sameAs 3197400078 @default.
• W3197400078 citedByCount "6" @default.
• W3197400078 countsByYear W31974000782022 @default.
• W3197400078 countsByYear W31974000782023 @default.
• W3197400078 crossrefType "journal-article" @default.
• W3197400078 hasAuthorship W3197400078A5017902843 @default.
• W3197400078 hasAuthorship W3197400078A5041832558 @default.
• W3197400078 hasAuthorship W3197400078A5061560498 @default.
• W3197400078 hasAuthorship W3197400078A5075008176 @default.
• W3197400078 hasAuthorship W3197400078A5080398549 @default.
• W3197400078 hasAuthorship W3197400078A5082016889 @default.
• W3197400078 hasConcept C105795698 @default.
• W3197400078 hasConcept C113196181 @default.
• W3197400078 hasConcept C151304367 @default.
• W3197400078 hasConcept C161584116 @default.
• W3197400078 hasConcept C185592680 @default.
• W3197400078 hasConcept C199163554 @default.
• W3197400078 hasConcept C22354355 @default.
• W3197400078 hasConcept C2780333294 @default.
• W3197400078 hasConcept C33923547 @default.
• W3197400078 hasConcept C42362537 @default.
• W3197400078 hasConcept C43617362 @default.
• W3197400078 hasConcept C48921125 @default.
• W3197400078 hasConcept C55493867 @default.
• W3197400078 hasConcept C62478195 @default.
• W3197400078 hasConcept C74887250 @default.
• W3197400078 hasConceptScore W3197400078C105795698 @default.
• W3197400078 hasConceptScore W3197400078C113196181 @default.
• W3197400078 hasConceptScore W3197400078C151304367 @default.
• W3197400078 hasConceptScore W3197400078C161584116 @default.
• W3197400078 hasConceptScore W3197400078C185592680 @default.
• W3197400078 hasConceptScore W3197400078C199163554 @default.
• W3197400078 hasConceptScore W3197400078C22354355 @default.
• W3197400078 hasConceptScore W3197400078C2780333294 @default.
• W3197400078 hasConceptScore W3197400078C33923547 @default.
• W3197400078 hasConceptScore W3197400078C42362537 @default.
• W3197400078 hasConceptScore W3197400078C43617362 @default.
• W3197400078 hasConceptScore W3197400078C48921125 @default.
• W3197400078 hasConceptScore W3197400078C55493867 @default.

• next