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• W3197408043 startingPage "1696" @default.
• W3197408043 abstract "Abstract Objectives This study was to investigate the polymorphism and distribution of alleles of HLA‐B*27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. Methods A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnosed according to Modified New York criteria were subtyped using the high‐resolution PCR‐SSP.Exon 2‐3 of HLA‐B*27 gene was amplified and sequenced to further confirm the HLA‐B*27 subtype. Results The frequency of HLA‐B*27 was 99.87% in AS patients. Three subtypes, HLA‐B*2704, HLA‐B*2705, and HLA‐B*2706 were identified. The frequencies for these three alleles were HLA‐B*2704 in 84/88 (95.46%), HLA‐B*2705 in 3/88(3.41%), and HLA‐B*2706 in 1/88 (1.13%) of the HLA‐B*27 positive patients, respectively. Conclusions Our study shows that HLA‐B*2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA‐B*27‐subtype distributions in Chinese Han populations showed that HLA‐B*2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA‐B*2705 show the opposite result." @default.
• W3197408043 created "2021-09-13" @default.
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• W3197408043 date "2021-09-09" @default.
• W3197408043 modified "2023-10-03" @default.
• W3197408043 title "Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China" @default.
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• W3197408043 doi "https://doi.org/10.1002/iid3.524" @default.
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• W3197408043 hasPublicationYear "2021" @default.
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