Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197408319> ?p ?o ?g. }
- W3197408319 abstract "Abstract The Six1 transcription factor is implicated in controlling the development of several tissue types, notably skeletal muscle. Six1 also contributes to muscle metabolism and its activity is associated with the fast-twitch, glycolytic phenotype. Six1 regulates the expression of certain genes of the fast muscle program by directly stimulating their transcription or indirectly acting through a long non-coding RNA. Under the hypothesis that additional mechanisms of action might be at play, a combined analysis of gene expression profiling and genome-wide location analysis data was performed. The Slc16a10 gene, encoding the thyroid hormone transmembrane transporter MCT10, was identified as a gene with a transcriptional enhancer directly bound by Six1 and requiring Six1 activity for full expression in adult mouse tibialis anterior, a predominantly fast-twitch muscle. Of the various thyroid hormone transporters, MCT10 mRNA was found to be the most abundant in skeletal muscle, and to have a stronger expression in fast-twitch compared to slow-twitch muscle groups. Loss-of-function of MCT10 in the tibialis anterior recapitulated the effect of Six1 on the expression of fast-twitch muscle genes and led to lower activity of a thyroid hormone receptor-dependent reporter gene. These results shed light on the molecular mechanisms controlling the tissue expression profile of MCT10 and identify modulation of the thyroid hormone signaling pathway as an additional mechanism by which Six1 influences skeletal muscle metabolism." @default.
- W3197408319 created "2021-09-13" @default.
- W3197408319 creator A5010258220 @default.
- W3197408319 creator A5019395364 @default.
- W3197408319 creator A5028869733 @default.
- W3197408319 creator A5058667188 @default.
- W3197408319 date "2021-08-27" @default.
- W3197408319 modified "2023-09-23" @default.
- W3197408319 title "Six1 Promotes Skeletal Muscle Thyroid Hormone Response through Regulation of the MCT10 Transporter" @default.
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