Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197450000> ?p ?o ?g. }
- W3197450000 endingPage "210148" @default.
- W3197450000 startingPage "210148" @default.
- W3197450000 abstract "Cancer stem cells (CSCs) are considered to contribute to the recurrence of lung cancer due to their stem-like nature and the involvement of genetic markers associated with drug efflux, regeneration and metastases. Photodynamic therapy (PDT) is a cost-effective and non-invasive therapeutic application that can act as an alternative therapy for lung cancer when considering CSC involvement. Stem-like cells derived from the A549 lung cancer cell line, positive for CD133, CD56 and CD44 antigen markers, were characterized, intracellular localization of aluminium (III) phthalocyanine chloride tetrasulphonate (AlPcS 4 Cl) determined and its anti-cancer PDT effects were evaluated. Results confirmed that isolated cells were stem cell-like and subcellular localization of AlPcS 4 Cl in integral organelles involved in cell homeostasis supported the destruction of CSC. AlPcS 4 Cl's effectivity was demonstrated with CSC eradication showing a significant increase in cytotoxicity and cell death via apoptosis, caused by a decrease in mitochondrial membrane potential. PDT could serve as a palliative treatment for lung cancer and improve prognosis by elimination of lung CSCs." @default.
- W3197450000 created "2021-09-13" @default.
- W3197450000 creator A5067892839 @default.
- W3197450000 creator A5072586638 @default.
- W3197450000 date "2021-09-01" @default.
- W3197450000 modified "2023-10-17" @default.
- W3197450000 title "Aluminium (III) phthalocyanine chloride tetrasulphonate is an effective photosensitizer for the eradication of lung cancer stem cells" @default.
- W3197450000 cites W1512723684 @default.
- W3197450000 cites W1701018835 @default.
- W3197450000 cites W1825578596 @default.
- W3197450000 cites W1953055438 @default.
- W3197450000 cites W1970168377 @default.
- W3197450000 cites W1982599299 @default.
- W3197450000 cites W1985418611 @default.
- W3197450000 cites W2002013266 @default.
- W3197450000 cites W2003404904 @default.
- W3197450000 cites W2003876192 @default.
- W3197450000 cites W2004878973 @default.
- W3197450000 cites W2006890215 @default.
- W3197450000 cites W2006986876 @default.
- W3197450000 cites W2007534995 @default.
- W3197450000 cites W2013614359 @default.
- W3197450000 cites W2022907966 @default.
- W3197450000 cites W2025786070 @default.
- W3197450000 cites W2026889493 @default.
- W3197450000 cites W2031348772 @default.
- W3197450000 cites W2035838265 @default.
- W3197450000 cites W2064389243 @default.
- W3197450000 cites W2073514222 @default.
- W3197450000 cites W2097259163 @default.
- W3197450000 cites W2102633393 @default.
- W3197450000 cites W2109273500 @default.
- W3197450000 cites W2114359573 @default.
- W3197450000 cites W2127582251 @default.
- W3197450000 cites W2151734986 @default.
- W3197450000 cites W2155528804 @default.
- W3197450000 cites W2163367650 @default.
- W3197450000 cites W2164844252 @default.
- W3197450000 cites W2170770305 @default.
- W3197450000 cites W2218971687 @default.
- W3197450000 cites W2256043817 @default.
- W3197450000 cites W2272315791 @default.
- W3197450000 cites W2282707216 @default.
- W3197450000 cites W2313523049 @default.
- W3197450000 cites W2334426315 @default.
- W3197450000 cites W2336135404 @default.
- W3197450000 cites W2396007914 @default.
- W3197450000 cites W2409980716 @default.
- W3197450000 cites W2512891139 @default.
- W3197450000 cites W2568658939 @default.
- W3197450000 cites W2586910727 @default.
- W3197450000 cites W2590947287 @default.
- W3197450000 cites W2623121460 @default.
- W3197450000 cites W2726322529 @default.
- W3197450000 cites W2734085570 @default.
- W3197450000 cites W2744285886 @default.
- W3197450000 cites W2762984243 @default.
- W3197450000 cites W2791923388 @default.
- W3197450000 cites W2831909719 @default.
- W3197450000 cites W2884145325 @default.
- W3197450000 cites W2901480442 @default.
- W3197450000 cites W2923459819 @default.
- W3197450000 cites W2929965180 @default.
- W3197450000 cites W2945502891 @default.
- W3197450000 cites W2968681930 @default.
- W3197450000 cites W2972194610 @default.
- W3197450000 cites W2999076721 @default.
- W3197450000 cites W2999137338 @default.
- W3197450000 cites W3000869056 @default.
- W3197450000 cites W3031529174 @default.
- W3197450000 cites W3039568349 @default.
- W3197450000 cites W4230982340 @default.
- W3197450000 doi "https://doi.org/10.1098/rsos.210148" @default.
- W3197450000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8424323" @default.
- W3197450000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34527268" @default.
- W3197450000 hasPublicationYear "2021" @default.
- W3197450000 type Work @default.
- W3197450000 sameAs 3197450000 @default.
- W3197450000 citedByCount "7" @default.
- W3197450000 countsByYear W31974500002022 @default.
- W3197450000 countsByYear W31974500002023 @default.
- W3197450000 crossrefType "journal-article" @default.
- W3197450000 hasAuthorship W3197450000A5067892839 @default.
- W3197450000 hasAuthorship W3197450000A5072586638 @default.
- W3197450000 hasBestOaLocation W31974500002 @default.
- W3197450000 hasConcept C121608353 @default.
- W3197450000 hasConcept C126322002 @default.
- W3197450000 hasConcept C142724271 @default.
- W3197450000 hasConcept C1491633281 @default.
- W3197450000 hasConcept C178790620 @default.
- W3197450000 hasConcept C185592680 @default.
- W3197450000 hasConcept C2776256026 @default.
- W3197450000 hasConcept C2780932548 @default.
- W3197450000 hasConcept C2781323092 @default.
- W3197450000 hasConcept C2781469039 @default.
- W3197450000 hasConcept C28328180 @default.
- W3197450000 hasConcept C502942594 @default.
- W3197450000 hasConcept C55427017 @default.