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- W3197459873 abstract "Enhancers and silencers often depend on the same transcription factors (TFs) and are conflated in genomic assays of TF binding or chromatin state. To identify sequence features that distinguish enhancers and silencers, we assayed massively parallel reporter libraries of genomic sequences targeted by the photoreceptor TF cone-rod homeobox (CRX) in mouse retinas. Both enhancers and silencers contain more TF motifs than inactive sequences, but relative to silencers, enhancers contain motifs from a more diverse collection of TFs. We developed a measure of information content that describes the number and diversity of motifs in a sequence and found that, while both enhancers and silencers depend on CRX motifs, enhancers have higher information content. The ability of information content to distinguish enhancers and silencers targeted by the same TF illustrates how motif context determines the activity of cis -regulatory sequences." @default.
- W3197459873 created "2021-09-13" @default.
- W3197459873 creator A5028632641 @default.
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- W3197459873 date "2021-09-06" @default.
- W3197459873 modified "2023-10-01" @default.
- W3197459873 title "Information content differentiates enhancers from silencers in mouse photoreceptors" @default.
- W3197459873 cites W1525882285 @default.
- W3197459873 cites W1585313030 @default.
- W3197459873 cites W1844738640 @default.
- W3197459873 cites W1964629749 @default.
- W3197459873 cites W1967195106 @default.
- W3197459873 cites W1974913126 @default.
- W3197459873 cites W1980504985 @default.
- W3197459873 cites W1980980049 @default.
- W3197459873 cites W1988581590 @default.
- W3197459873 cites W1988785321 @default.
- W3197459873 cites W1993392563 @default.
- W3197459873 cites W2002964220 @default.
- W3197459873 cites W2007694108 @default.
- W3197459873 cites W2011301426 @default.
- W3197459873 cites W2013414181 @default.
- W3197459873 cites W2013554145 @default.
- W3197459873 cites W2018363492 @default.
- W3197459873 cites W2024520070 @default.
- W3197459873 cites W2025530693 @default.
- W3197459873 cites W2027066480 @default.
- W3197459873 cites W2027368464 @default.
- W3197459873 cites W2027469999 @default.
- W3197459873 cites W2035942502 @default.
- W3197459873 cites W2039441672 @default.
- W3197459873 cites W2041999717 @default.
- W3197459873 cites W2045362835 @default.
- W3197459873 cites W2046667570 @default.
- W3197459873 cites W2046842005 @default.
- W3197459873 cites W2049890303 @default.
- W3197459873 cites W2051278630 @default.
- W3197459873 cites W2059344357 @default.
- W3197459873 cites W2062075767 @default.
- W3197459873 cites W2072414883 @default.
- W3197459873 cites W2083823883 @default.
- W3197459873 cites W2086876386 @default.
- W3197459873 cites W2092997109 @default.
- W3197459873 cites W2099105062 @default.
- W3197459873 cites W2102619694 @default.
- W3197459873 cites W2107118825 @default.
- W3197459873 cites W2114715558 @default.
- W3197459873 cites W2117193130 @default.
- W3197459873 cites W2122194644 @default.
- W3197459873 cites W2125716773 @default.
- W3197459873 cites W2130458525 @default.
- W3197459873 cites W2140754446 @default.
- W3197459873 cites W2141215651 @default.
- W3197459873 cites W2142644426 @default.
- W3197459873 cites W2147635933 @default.
- W3197459873 cites W2153115129 @default.
- W3197459873 cites W2155015939 @default.
- W3197459873 cites W2157009395 @default.
- W3197459873 cites W2157191738 @default.
- W3197459873 cites W2159864583 @default.
- W3197459873 cites W2161957615 @default.
- W3197459873 cites W2166691503 @default.
- W3197459873 cites W2198606573 @default.
- W3197459873 cites W2286751849 @default.
- W3197459873 cites W2307093200 @default.
- W3197459873 cites W2308616703 @default.
- W3197459873 cites W2345512687 @default.
- W3197459873 cites W2345943684 @default.
- W3197459873 cites W2414763988 @default.
- W3197459873 cites W2536763320 @default.
- W3197459873 cites W2591919483 @default.
- W3197459873 cites W2767749844 @default.
- W3197459873 cites W2887901397 @default.
- W3197459873 cites W2889201683 @default.
- W3197459873 cites W2899616402 @default.
- W3197459873 cites W2910641511 @default.
- W3197459873 cites W2911555896 @default.
- W3197459873 cites W2922109697 @default.
- W3197459873 cites W2946122061 @default.
- W3197459873 cites W2984395420 @default.
- W3197459873 cites W2995997429 @default.
- W3197459873 cites W3007150393 @default.
- W3197459873 cites W3008725968 @default.
- W3197459873 cites W3008828407 @default.
- W3197459873 cites W3045910546 @default.
- W3197459873 cites W3046699218 @default.
- W3197459873 cites W3099878876 @default.
- W3197459873 cites W3103145119 @default.
- W3197459873 cites W3125946770 @default.
- W3197459873 cites W3134994147 @default.
- W3197459873 cites W4230397979 @default.
- W3197459873 cites W4230875896 @default.
- W3197459873 cites W4253281475 @default.
- W3197459873 doi "https://doi.org/10.7554/elife.67403" @default.
- W3197459873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8492058" @default.
- W3197459873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34486522" @default.