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• W3197463876 abstract "Abstract Epstein–Barr virus (EBV) and cytomegalovirus (CMV) reactivations are common complications after allogeneic hematopoietic cell transplantation (allo-HCT), but data focusing on non–Hodgkin lymphoma (NHL) are limited. We retrospectively analyzed the prevalence of EBV and CMV reactivation post-allo-HCT and the impacts on transplant outcomes in 160 NHL patients. The 1-year incidences of EBV and CMV reactivation were 22.58% and 25.55%, respectively. Independent impactors for EBV reactivation were more than 6 lines of chemotherapy ( P = 0.030), use of rituximab ( P = 0.004), and neutrophil recovery within 30 days post-HCT ( P = 0.022). For T-cell lymphoblastic lymphoma patients, the International Prognostic Index (IPI) ( P = 0.015) and chronic GVHD ( P = 0.001) increased the risk of CMV reactivation. CMV reactivation was independently related to a lower risk of relapse ( P = 0.027) but higher transplant-related mortality (TRM) ( P = 0.038). Although viral reactivation had no significant impact on overall survival (OS) in the whole cohort, it led to an inferior 2-year OS (67.6% versus 92.5%, P = 0.005) and TRM (20.1% versus 4.7%, P = 0.020) in recipients surviving for more than 180 days. We concluded that EBV and CMV reactivation post-allotransplant still deserved concern particularly in NHL patients with high-risk factors, since it is generally related to a deteriorated prognosis. Large-scale studies are warranted to validate our findings." @default.
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• W3197463876 date "2021-09-04" @default.
• W3197463876 modified "2023-10-09" @default.
• W3197463876 title "Epstein–Barr virus and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation in patients with non–Hodgkin lymphoma: the prevalence and impacts on outcomes" @default.
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• W3197463876 doi "https://doi.org/10.1007/s00277-021-04642-5" @default.
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