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- W3197471843 endingPage "2345" @default.
- W3197471843 startingPage "2345" @default.
- W3197471843 abstract "Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma, which result in the accumulation of an oncometabolite, D-2-hydroxyglutarate (D-2-HG). Abnormally elevated D-2-HG levels result in a distinctive pattern in cancer biology, through competitively inhibiting α-ketoglutarate (α-KG)/Fe(II)-dependent dioxgenases (α-KGDDs). Recent studies have revealed that D-2-HG affects DNA/histone methylation, hypoxia signaling, DNA repair, and redox homeostasis, which impacts the oncogenesis of IDH-mutated cancers. In this review, we will discuss the current understanding of D-2-HG in cancer biology, as well as the emerging opportunities in therapeutics in IDH-mutated glioma." @default.
- W3197471843 created "2021-09-13" @default.
- W3197471843 creator A5002752290 @default.
- W3197471843 creator A5009443091 @default.
- W3197471843 creator A5026621558 @default.
- W3197471843 creator A5074085643 @default.
- W3197471843 date "2021-09-07" @default.
- W3197471843 modified "2023-10-16" @default.
- W3197471843 title "D-2-Hydroxyglutarate in Glioma Biology" @default.
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