Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197474466> ?p ?o ?g. }
- W3197474466 endingPage "43951" @default.
- W3197474466 startingPage "43937" @default.
- W3197474466 abstract "Nanotechnology has emerged as a promising solution to permanent elimination of cancer. However, nanoparticles themselves lack specificity to tumors. Due to enhanced migration to tumors, mesenchymal stem cells (MSCs) were suggested as cell-mediated delivery vehicles of nanoparticles. In this study, we have constructed a complex composed of photoluminescent quantum dots (QDs) and a photosensitizer chlorin e6 (Ce6) to obtain multifunctional nanoparticles, combining cancer diagnostic and therapeutic properties. QDs serve as energy donors-excited QDs transfer energy to the attached Ce6 via Förster resonance energy transfer, which in turn generates reactive oxygen species. Here, the physicochemical properties of the QD-Ce6 complex and singlet oxygen generation were measured, and the stability in protein-rich media was evaluated, showing that the complex remains the most stable in protein-free medium. In vitro studies on MSC and cancer cell response to the QD-Ce6 complex revealed the complex-loaded MSCs' potential to transport theranostic nanoparticles and induce cancer cell death. In vivo studies proved the therapeutic efficacy, as the survival of tumor-bearing mice was statistically significantly increased, while tumor progression and metastases were slowed down." @default.
- W3197474466 created "2021-09-13" @default.
- W3197474466 creator A5017807548 @default.
- W3197474466 creator A5030362542 @default.
- W3197474466 creator A5047344148 @default.
- W3197474466 creator A5048025471 @default.
- W3197474466 creator A5050031829 @default.
- W3197474466 creator A5071705209 @default.
- W3197474466 date "2021-09-09" @default.
- W3197474466 modified "2023-10-10" @default.
- W3197474466 title "Hitchhiking Nanoparticles: Mesenchymal Stem Cell-Mediated Delivery of Theranostic Nanoparticles" @default.
- W3197474466 cites W1526894457 @default.
- W3197474466 cites W166079536 @default.
- W3197474466 cites W1973590977 @default.
- W3197474466 cites W1992572186 @default.
- W3197474466 cites W1995284991 @default.
- W3197474466 cites W1999694057 @default.
- W3197474466 cites W2005589110 @default.
- W3197474466 cites W2006689309 @default.
- W3197474466 cites W2013331208 @default.
- W3197474466 cites W2025371271 @default.
- W3197474466 cites W2026349248 @default.
- W3197474466 cites W2033064466 @default.
- W3197474466 cites W2061514685 @default.
- W3197474466 cites W2061650771 @default.
- W3197474466 cites W2063243732 @default.
- W3197474466 cites W2072899346 @default.
- W3197474466 cites W2082651961 @default.
- W3197474466 cites W2087273713 @default.
- W3197474466 cites W2087502781 @default.
- W3197474466 cites W2087997950 @default.
- W3197474466 cites W2096680191 @default.
- W3197474466 cites W2116448420 @default.
- W3197474466 cites W2121774318 @default.
- W3197474466 cites W2125793635 @default.
- W3197474466 cites W2150978636 @default.
- W3197474466 cites W2167607926 @default.
- W3197474466 cites W2206020846 @default.
- W3197474466 cites W2278726896 @default.
- W3197474466 cites W2292437912 @default.
- W3197474466 cites W2335660417 @default.
- W3197474466 cites W2588347623 @default.
- W3197474466 cites W2591628935 @default.
- W3197474466 cites W2622671312 @default.
- W3197474466 cites W2727345969 @default.
- W3197474466 cites W2767784675 @default.
- W3197474466 cites W2784680908 @default.
- W3197474466 cites W2793434722 @default.
- W3197474466 cites W2800910839 @default.
- W3197474466 cites W2808189499 @default.
- W3197474466 cites W2883592031 @default.
- W3197474466 cites W2884145325 @default.
- W3197474466 cites W2884304605 @default.
- W3197474466 cites W2893560105 @default.
- W3197474466 cites W2897827263 @default.
- W3197474466 cites W2903323709 @default.
- W3197474466 cites W2906040171 @default.
- W3197474466 cites W2908219275 @default.
- W3197474466 cites W2909748727 @default.
- W3197474466 cites W2937792746 @default.
- W3197474466 cites W2965625649 @default.
- W3197474466 cites W2990574737 @default.
- W3197474466 cites W2995340618 @default.
- W3197474466 cites W2996926540 @default.
- W3197474466 cites W3046442278 @default.
- W3197474466 cites W3084235196 @default.
- W3197474466 cites W3117706574 @default.
- W3197474466 cites W3131442105 @default.
- W3197474466 cites W4211024586 @default.
- W3197474466 doi "https://doi.org/10.1021/acsami.1c10445" @default.
- W3197474466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34499462" @default.
- W3197474466 hasPublicationYear "2021" @default.
- W3197474466 type Work @default.
- W3197474466 sameAs 3197474466 @default.
- W3197474466 citedByCount "12" @default.
- W3197474466 countsByYear W31974744662022 @default.
- W3197474466 countsByYear W31974744662023 @default.
- W3197474466 crossrefType "journal-article" @default.
- W3197474466 hasAuthorship W3197474466A5017807548 @default.
- W3197474466 hasAuthorship W3197474466A5030362542 @default.
- W3197474466 hasAuthorship W3197474466A5047344148 @default.
- W3197474466 hasAuthorship W3197474466A5048025471 @default.
- W3197474466 hasAuthorship W3197474466A5050031829 @default.
- W3197474466 hasAuthorship W3197474466A5071705209 @default.
- W3197474466 hasConcept C121608353 @default.
- W3197474466 hasConcept C12554922 @default.
- W3197474466 hasConcept C126322002 @default.
- W3197474466 hasConcept C150903083 @default.
- W3197474466 hasConcept C155672457 @default.
- W3197474466 hasConcept C171250308 @default.
- W3197474466 hasConcept C178790620 @default.
- W3197474466 hasConcept C185592680 @default.
- W3197474466 hasConcept C192562407 @default.
- W3197474466 hasConcept C198826908 @default.
- W3197474466 hasConcept C207001950 @default.
- W3197474466 hasConcept C2777516457 @default.
- W3197474466 hasConcept C2781323092 @default.
- W3197474466 hasConcept C2781469039 @default.