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• W3197481145 endingPage "224" @default.
• W3197481145 startingPage "205" @default.
• W3197481145 abstract "Approximately 7% of pregnant women in the United States use electronic-cigarette (e-cig) devices during pregnancy. There is, however, no scientific evidence to support e-cig use as being 'safe' during pregnancy. Little is known about the effects of fetal exposures to e-cig aerosols on lung alveologenesis. In the present study, we tested the hypothesis that in utero exposure to e-cig aerosol impairs lung alveologenesis and pulmonary function in neonates. Pregnant BALB/c mice were exposed 2 h a day for 20 consecutive days during gestation to either filtered air or cinnamon-flavored e-cig aerosol (36 mg/mL of nicotine). Lung tissue was collected in offspring during lung alveologenesis on postnatal day (PND) 5 and PND11. Lung function was measured at PND11. Exposure to e-cig aerosol in utero led to a significant decrease in body weights at birth which was sustained through PND5. At PND5, in utero e-cig exposures dysregulated genes related to Wnt signaling and epigenetic modifications in both females (~ 120 genes) and males (40 genes). These alterations were accompanied by reduced lung fibrillar collagen content at PND5-a time point when collagen content is close to its peak to support alveoli formation. In utero exposure to e-cig aerosol also increased the Newtonian resistance of offspring at PND11, suggesting a narrowing of the conducting airways. At PND11, in females, transcriptomic dysregulation associated with epigenetic alterations was sustained (17 genes), while WNT signaling dysregulation was largely resolved (10 genes). In males, at PND11, the expression of only 4 genes associated with epigenetics was dysregulated, while 16 Wnt related-genes were altered. These data demonstrate that in utero exposures to cinnamon-flavored e-cig aerosols alter lung structure and function and induce sex-specific molecular signatures during lung alveologenesis in neonatal mice. This may reflect epigenetic programming affecting lung disease development later in life." @default.
• W3197481145 created "2021-09-13" @default.
• W3197481145 creator A5017827064 @default.
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• W3197481145 date "2021-09-06" @default.
• W3197481145 modified "2023-10-16" @default.
• W3197481145 title "In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice" @default.
• W3197481145 cites W1485889529 @default.
• W3197481145 cites W1510921382 @default.
• W3197481145 cites W1583019491 @default.
• W3197481145 cites W1617043071 @default.
• W3197481145 cites W188657582 @default.
• W3197481145 cites W1891629748 @default.
• W3197481145 cites W1924671000 @default.
• W3197481145 cites W1967943295 @default.
• W3197481145 cites W1971876086 @default.
• W3197481145 cites W1974137536 @default.
• W3197481145 cites W1978714931 @default.
• W3197481145 cites W1994408278 @default.
• W3197481145 cites W1997745506 @default.
• W3197481145 cites W2007047283 @default.
• W3197481145 cites W2011050399 @default.
• W3197481145 cites W2026933978 @default.
• W3197481145 cites W2028204495 @default.
• W3197481145 cites W2032917789 @default.
• W3197481145 cites W2036825243 @default.
• W3197481145 cites W2050782580 @default.
• W3197481145 cites W2051268137 @default.
• W3197481145 cites W2053834750 @default.
• W3197481145 cites W2071483937 @default.
• W3197481145 cites W2072889142 @default.
• W3197481145 cites W2073157961 @default.
• W3197481145 cites W2074287725 @default.
• W3197481145 cites W2075715913 @default.
• W3197481145 cites W2077342495 @default.
• W3197481145 cites W2081236672 @default.
• W3197481145 cites W2084413840 @default.
• W3197481145 cites W2087728858 @default.
• W3197481145 cites W2091222423 @default.
• W3197481145 cites W2096234961 @default.
• W3197481145 cites W2101526557 @default.
• W3197481145 cites W2102739523 @default.
• W3197481145 cites W2103255998 @default.
• W3197481145 cites W2107806912 @default.
• W3197481145 cites W2108085189 @default.
• W3197481145 cites W2121958146 @default.
• W3197481145 cites W2122040595 @default.
• W3197481145 cites W2122459914 @default.
• W3197481145 cites W2133465414 @default.
• W3197481145 cites W2134368652 @default.
• W3197481145 cites W2135080130 @default.
• W3197481145 cites W2141791068 @default.
• W3197481145 cites W2144014211 @default.
• W3197481145 cites W2150170982 @default.
• W3197481145 cites W2151821895 @default.
• W3197481145 cites W2157894499 @default.
• W3197481145 cites W2158217645 @default.
• W3197481145 cites W2160087042 @default.
• W3197481145 cites W2163574165 @default.
• W3197481145 cites W2166262138 @default.
• W3197481145 cites W2167425774 @default.
• W3197481145 cites W2174327813 @default.
• W3197481145 cites W2191285796 @default.
• W3197481145 cites W2232906764 @default.
• W3197481145 cites W2256939761 @default.
• W3197481145 cites W2330784827 @default.
• W3197481145 cites W2330806633 @default.
• W3197481145 cites W2337088505 @default.
• W3197481145 cites W2517538025 @default.
• W3197481145 cites W2518473133 @default.
• W3197481145 cites W2519254671 @default.
• W3197481145 cites W2547424243 @default.
• W3197481145 cites W2552834938 @default.
• W3197481145 cites W2581022129 @default.
• W3197481145 cites W2602783738 @default.
• W3197481145 cites W2607935660 @default.
• W3197481145 cites W2612617411 @default.
• W3197481145 cites W2613259465 @default.
• W3197481145 cites W2616038640 @default.
• W3197481145 cites W2619721446 @default.
• W3197481145 cites W2671981991 @default.
• W3197481145 cites W2734318655 @default.
• W3197481145 cites W2748656499 @default.
• W3197481145 cites W2750941126 @default.
• W3197481145 cites W2759370647 @default.
• W3197481145 cites W2759487020 @default.
• W3197481145 cites W2765098017 @default.
• W3197481145 cites W2767735095 @default.
• W3197481145 cites W2775863097 @default.
• W3197481145 cites W2790455901 @default.
• W3197481145 cites W2791142331 @default.
• W3197481145 cites W2792120917 @default.

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