FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197486368> ?p ?o ?g. }

• W3197486368 endingPage "274" @default.
• W3197486368 startingPage "271" @default.
• W3197486368 abstract "Vertebral bone and limb bone are formed by endochondral ossification, which is replaced with bone tissue by osteoblasts after cartilage formation. Bone growth is regulated by the balance between epiphyseal chondrocyte proliferation and ossification. We attempted to elucidate the mechanism of chondrocyte differentiation and maturation regulated by the Extracellular-signal-regulated kinase 5 (Erk5) signal. Erk5 is a serine/threonine kinase belonging to the mitogen-activated protein kinase (MAPK) family, which includes Erk1/2, JNK, and p38. Mesenchymal stem cell-specific Erk5-deficient mice exhibited the phenotype of deformities of the metatarsal bones, enlargement of the long bones in limbs, and overgrowth of cartilage tissue. Based on this result, we searched for factors that directly phosphorylate Erk5, and We demonstrated that Erk5 directly phosphorylates and activates Smurf2 (a ubiquitin E3 ligase) at Thr249 to activate its function and promotes ubiquitination-mediated degradation. The TGF-β-Smad signal suppresses the proliferation of many cells and regulates the production of extracellular matrix. Our findings may lead to the development of novel drugs targeting TGF-β associated diseases. In this paper, we investigated the function of Smurf2Thr249 phosphorylation and the possibility as new therapeutic target for various diseases." @default.
• W3197486368 created "2021-09-13" @default.
• W3197486368 creator A5025834236 @default.
• W3197486368 creator A5034651554 @default.
• W3197486368 date "2021-01-01" @default.
• W3197486368 modified "2023-09-25" @default.
• W3197486368 title "Phosphorylation of Smurf2 at Thr249 by Erk5 regulates TGF-β signaling" @default.
• W3197486368 cites W1770121422 @default.
• W3197486368 cites W1974347350 @default.
• W3197486368 cites W1994115179 @default.
• W3197486368 cites W1994187452 @default.
• W3197486368 cites W1996405087 @default.
• W3197486368 cites W1998809668 @default.
• W3197486368 cites W1999155906 @default.
• W3197486368 cites W2068696415 @default.
• W3197486368 cites W2070204715 @default.
• W3197486368 cites W2075104267 @default.
• W3197486368 cites W2079753883 @default.
• W3197486368 cites W2093335995 @default.
• W3197486368 cites W2120246444 @default.
• W3197486368 cites W2122808924 @default.
• W3197486368 cites W2126840542 @default.
• W3197486368 cites W2128756225 @default.
• W3197486368 cites W2134468110 @default.
• W3197486368 cites W2136280424 @default.
• W3197486368 cites W2136921951 @default.
• W3197486368 cites W2170242482 @default.
• W3197486368 cites W2606001457 @default.
• W3197486368 cites W2649656222 @default.
• W3197486368 cites W2909123075 @default.
• W3197486368 cites W2998373386 @default.
• W3197486368 cites W3094526479 @default.
• W3197486368 cites W4230421038 @default.
• W3197486368 cites W4296927411 @default.
• W3197486368 doi "https://doi.org/10.1254/fpj.21029" @default.
• W3197486368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34470930" @default.
• W3197486368 hasPublicationYear "2021" @default.
• W3197486368 type Work @default.
• W3197486368 sameAs 3197486368 @default.
• W3197486368 citedByCount "0" @default.
• W3197486368 crossrefType "journal-article" @default.
• W3197486368 hasAuthorship W3197486368A5025834236 @default.
• W3197486368 hasAuthorship W3197486368A5034651554 @default.
• W3197486368 hasConcept C104317684 @default.
• W3197486368 hasConcept C105702510 @default.
• W3197486368 hasConcept C11960822 @default.
• W3197486368 hasConcept C134459356 @default.
• W3197486368 hasConcept C17938293 @default.
• W3197486368 hasConcept C184235292 @default.
• W3197486368 hasConcept C185592680 @default.
• W3197486368 hasConcept C189165786 @default.
• W3197486368 hasConcept C25602115 @default.
• W3197486368 hasConcept C2778842504 @default.
• W3197486368 hasConcept C2780550940 @default.
• W3197486368 hasConcept C2781080636 @default.
• W3197486368 hasConcept C2781403057 @default.
• W3197486368 hasConcept C51551487 @default.
• W3197486368 hasConcept C55493867 @default.
• W3197486368 hasConcept C57074206 @default.
• W3197486368 hasConcept C62478195 @default.
• W3197486368 hasConcept C86803240 @default.
• W3197486368 hasConcept C95444343 @default.
• W3197486368 hasConcept C97029542 @default.
• W3197486368 hasConceptScore W3197486368C104317684 @default.
• W3197486368 hasConceptScore W3197486368C105702510 @default.
• W3197486368 hasConceptScore W3197486368C11960822 @default.
• W3197486368 hasConceptScore W3197486368C134459356 @default.
• W3197486368 hasConceptScore W3197486368C17938293 @default.
• W3197486368 hasConceptScore W3197486368C184235292 @default.
• W3197486368 hasConceptScore W3197486368C185592680 @default.
• W3197486368 hasConceptScore W3197486368C189165786 @default.
• W3197486368 hasConceptScore W3197486368C25602115 @default.
• W3197486368 hasConceptScore W3197486368C2778842504 @default.
• W3197486368 hasConceptScore W3197486368C2780550940 @default.
• W3197486368 hasConceptScore W3197486368C2781080636 @default.
• W3197486368 hasConceptScore W3197486368C2781403057 @default.
• W3197486368 hasConceptScore W3197486368C51551487 @default.
• W3197486368 hasConceptScore W3197486368C55493867 @default.
• W3197486368 hasConceptScore W3197486368C57074206 @default.
• W3197486368 hasConceptScore W3197486368C62478195 @default.
• W3197486368 hasConceptScore W3197486368C86803240 @default.
• W3197486368 hasConceptScore W3197486368C95444343 @default.
• W3197486368 hasConceptScore W3197486368C97029542 @default.
• W3197486368 hasIssue "5" @default.
• W3197486368 hasLocation W31974863681 @default.
• W3197486368 hasLocation W31974863682 @default.
• W3197486368 hasOpenAccess W3197486368 @default.
• W3197486368 hasPrimaryLocation W31974863681 @default.
• W3197486368 hasRelatedWork W1976734851 @default.
• W3197486368 hasRelatedWork W2010932108 @default.
• W3197486368 hasRelatedWork W2027244603 @default.
• W3197486368 hasRelatedWork W2041745288 @default.
• W3197486368 hasRelatedWork W2058202339 @default.
• W3197486368 hasRelatedWork W2791193457 @default.
• W3197486368 hasRelatedWork W2978781268 @default.
• W3197486368 hasRelatedWork W3035328115 @default.
• W3197486368 hasRelatedWork W3141260101 @default.
• W3197486368 hasRelatedWork W4254421120 @default.

• next