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- W3197489165 abstract "Despite overall success, T cell checkpoint inhibitors for cancer treatment are still only efficient in a minority of patients. Recently, intestinal microbiota was found to critically modulate anti-cancer immunity and therapy response. Here, we identify Clostridiales members of the gut microbiota associated with a lower tumor burden in mouse models of colorectal cancer (CRC). Interestingly, these commensal species are also significantly reduced in CRC patients compared with healthy controls. Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8+ T cells. Single application of Roseburia intestinalis or Anaerostipes caccae was even more effective than CC4. In a direct comparison, the CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma. Our findings provide a strong preclinical foundation for exploring gut bacteria as novel stand-alone therapy against solid tumors." @default.
- W3197489165 created "2021-09-13" @default.
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- W3197489165 date "2021-10-01" @default.
- W3197489165 modified "2023-10-16" @default.
- W3197489165 title "Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors" @default.
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- W3197489165 doi "https://doi.org/10.1016/j.chom.2021.08.001" @default.