FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197493883> ?p ?o ?g. }

• W3197493883 abstract "Purinergic signaling mediated by ATP and its metabolites contributes to various brain physiological processes as well as to several pathological conditions, including neurodegenerative and neurological disorders, such as epilepsy. Among the different ATP release pathways, pannexin 1 channels represent one of the major conduits being primarily activated in pathological contexts. Investigations on in vitro and in vivo models of epileptiform activity and seizures in mice and human tissues revealed pannexin 1 involvement in aberrant network activity and epilepsy, and highlighted that pannexin 1 exerts a complex role. Pannexin 1 can indeed either sustain seizures through release of ATP that can directly activate purinergic receptors, or tune down epileptic activity via ATP-derived adenosine that decreases neuronal excitability. Interestingly, in-depth analysis of the literature unveils that this dichotomy is only apparent, as it depends on the model of seizure induction and the type of evoked epileptiform activity, two factors that can differentially activate pannexin 1 channels and trigger distinct intracellular signaling cascades. Here, we review the general properties and ATP permeability of pannexin 1 channels, and discuss their impact on acute epileptiform activity and chronic epilepsy according to the regime of activity and disease state. These data pave the way for the development of new antiepileptic strategies selectively targeting pannexin 1 channels in a context-dependent manner." @default.
• W3197493883 created "2021-09-13" @default.
• W3197493883 creator A5000510243 @default.
• W3197493883 creator A5033299269 @default.
• W3197493883 date "2021-09-08" @default.
• W3197493883 modified "2023-09-26" @default.
• W3197493883 title "Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin" @default.
• W3197493883 cites W1003328916 @default.
• W3197493883 cites W1514493016 @default.
• W3197493883 cites W1964600153 @default.
• W3197493883 cites W1967416789 @default.
• W3197493883 cites W1968418688 @default.
• W3197493883 cites W1969676181 @default.
• W3197493883 cites W1971084572 @default.
• W3197493883 cites W1974809694 @default.
• W3197493883 cites W1975146387 @default.
• W3197493883 cites W1978254950 @default.
• W3197493883 cites W1982322107 @default.
• W3197493883 cites W1982473707 @default.
• W3197493883 cites W1984715761 @default.
• W3197493883 cites W1985473475 @default.
• W3197493883 cites W1989638595 @default.
• W3197493883 cites W1992950423 @default.
• W3197493883 cites W1993093440 @default.
• W3197493883 cites W1995256270 @default.
• W3197493883 cites W1995307208 @default.
• W3197493883 cites W2000341627 @default.
• W3197493883 cites W2000705375 @default.
• W3197493883 cites W2004017387 @default.
• W3197493883 cites W2005554059 @default.
• W3197493883 cites W2012101044 @default.
• W3197493883 cites W2019047748 @default.
• W3197493883 cites W2019245227 @default.
• W3197493883 cites W2021477438 @default.
• W3197493883 cites W2022023926 @default.
• W3197493883 cites W2028756092 @default.
• W3197493883 cites W2033803440 @default.
• W3197493883 cites W2034465562 @default.
• W3197493883 cites W2035971243 @default.
• W3197493883 cites W2041034105 @default.
• W3197493883 cites W2042259903 @default.
• W3197493883 cites W2043713627 @default.
• W3197493883 cites W2049619102 @default.
• W3197493883 cites W2050886623 @default.
• W3197493883 cites W2051233560 @default.
• W3197493883 cites W2051769838 @default.
• W3197493883 cites W2054784650 @default.
• W3197493883 cites W2056123178 @default.
• W3197493883 cites W2059030264 @default.
• W3197493883 cites W2067543002 @default.
• W3197493883 cites W2072542349 @default.
• W3197493883 cites W2073414804 @default.
• W3197493883 cites W2075457457 @default.
• W3197493883 cites W2077857158 @default.
• W3197493883 cites W2079901569 @default.
• W3197493883 cites W2080297939 @default.
• W3197493883 cites W2081308255 @default.
• W3197493883 cites W2085780740 @default.
• W3197493883 cites W2086215356 @default.
• W3197493883 cites W2087700724 @default.
• W3197493883 cites W2092243795 @default.
• W3197493883 cites W2097826375 @default.
• W3197493883 cites W2100067618 @default.
• W3197493883 cites W2101481749 @default.
• W3197493883 cites W2105748851 @default.
• W3197493883 cites W2106643106 @default.
• W3197493883 cites W2120666811 @default.
• W3197493883 cites W2126453456 @default.
• W3197493883 cites W2138977093 @default.
• W3197493883 cites W2141480740 @default.
• W3197493883 cites W2141571472 @default.
• W3197493883 cites W2154979821 @default.
• W3197493883 cites W2157338202 @default.
• W3197493883 cites W2159590959 @default.
• W3197493883 cites W2160120610 @default.
• W3197493883 cites W2161114503 @default.
• W3197493883 cites W2165004755 @default.
• W3197493883 cites W2165050023 @default.
• W3197493883 cites W2167750958 @default.
• W3197493883 cites W2266707315 @default.
• W3197493883 cites W2276785691 @default.
• W3197493883 cites W2292615460 @default.
• W3197493883 cites W2339391953 @default.
• W3197493883 cites W2567270775 @default.
• W3197493883 cites W2580573398 @default.
• W3197493883 cites W2582947238 @default.
• W3197493883 cites W2605273211 @default.
• W3197493883 cites W2613316447 @default.
• W3197493883 cites W2615068576 @default.
• W3197493883 cites W2753845665 @default.
• W3197493883 cites W2772617244 @default.
• W3197493883 cites W2791781885 @default.
• W3197493883 cites W2801167890 @default.
• W3197493883 cites W2805363626 @default.
• W3197493883 cites W2898611747 @default.
• W3197493883 cites W2901942715 @default.
• W3197493883 cites W2920861514 @default.
• W3197493883 cites W2932725017 @default.
• W3197493883 cites W2945648548 @default.
• W3197493883 cites W2946271004 @default.

• next