FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197496434> ?p ?o ?g. }

• W3197496434 abstract "High body mass index (BMI) is an important predictor of mortality but estimating underlying causality is hampered by confounding and pre-existing disease. Here, we use information from the offspring to approximate parental BMIs, with an aim to avoid biased estimation of mortality risk caused by reverse causality.The analyses were based on information on 9674 offspring-mother and 9096 offspring-father pairs obtained from the 1958 British birth cohort. Parental BMI-mortality associations were analysed using conventional methods and using offspring BMI as a proxy, or instrument, for their parents' BMI.In the conventional analysis, associations between parental BMI and all-cause mortality were U-shaped (Pcurvature < 0.001), while offspring BMI had linear associations with parental mortality (Ptrend < 0.001, Pcurvature > 0.46). Curvature was particularly pronounced for mortality from respiratory diseases and from lung cancer. Instrumental variable analyses suggested a positive association between BMI and mortality from all causes [mothers: HR per SD of BMI 1.43 (95% CI 1.21-1.69), fathers: HR 1.17 (1.00-1.36)] and from coronary heart disease [mothers: HR 1.65 (1.15-2.36), fathers: HR 1.51 (1.17-1.97)]. These were larger than HR from the equivalent conventional analyses, despite some attenuation by adjustment for social indicators and smoking.Analyses using offspring BMI as a proxy for parental BMI suggest that the apparent adverse consequences of low BMI are considerably overestimated and adverse consequences of overweight are underestimated in conventional epidemiological studies." @default.
• W3197496434 created "2021-09-13" @default.
• W3197496434 creator A5003375657 @default.
• W3197496434 creator A5013184354 @default.
• W3197496434 creator A5026971838 @default.
• W3197496434 creator A5041283916 @default.
• W3197496434 creator A5048993625 @default.
• W3197496434 date "2021-09-08" @default.
• W3197496434 modified "2023-10-17" @default.
• W3197496434 title "Estimating the influence of body mass index (BMI) on mortality using offspring BMI as an instrumental variable" @default.
• W3197496434 cites W1564669788 @default.
• W3197496434 cites W1587388782 @default.
• W3197496434 cites W1836053207 @default.
• W3197496434 cites W1978281808 @default.
• W3197496434 cites W1999901440 @default.
• W3197496434 cites W2009678236 @default.
• W3197496434 cites W2009979998 @default.
• W3197496434 cites W2015046142 @default.
• W3197496434 cites W2015187260 @default.
• W3197496434 cites W2016681893 @default.
• W3197496434 cites W2024910853 @default.
• W3197496434 cites W2033405149 @default.
• W3197496434 cites W2036616295 @default.
• W3197496434 cites W2039063847 @default.
• W3197496434 cites W2039421379 @default.
• W3197496434 cites W2046032521 @default.
• W3197496434 cites W2075455650 @default.
• W3197496434 cites W2088649670 @default.
• W3197496434 cites W2094832883 @default.
• W3197496434 cites W2104033312 @default.
• W3197496434 cites W2111793219 @default.
• W3197496434 cites W2120919020 @default.
• W3197496434 cites W2127767012 @default.
• W3197496434 cites W2131715067 @default.
• W3197496434 cites W2136981372 @default.
• W3197496434 cites W2142170772 @default.
• W3197496434 cites W2158226607 @default.
• W3197496434 cites W2168512066 @default.
• W3197496434 cites W2337943012 @default.
• W3197496434 cites W2338864525 @default.
• W3197496434 cites W2420070117 @default.
• W3197496434 cites W2471009590 @default.
• W3197496434 cites W2483210912 @default.
• W3197496434 cites W2499691332 @default.
• W3197496434 cites W2898488407 @default.
• W3197496434 cites W2900455732 @default.
• W3197496434 cites W2908573242 @default.
• W3197496434 cites W2960982432 @default.
• W3197496434 doi "https://doi.org/10.1038/s41366-021-00962-8" @default.
• W3197496434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34497352" @default.
• W3197496434 hasPublicationYear "2021" @default.
• W3197496434 type Work @default.
• W3197496434 sameAs 3197496434 @default.
• W3197496434 citedByCount "1" @default.
• W3197496434 countsByYear W31974964342022 @default.
• W3197496434 crossrefType "journal-article" @default.
• W3197496434 hasAuthorship W3197496434A5003375657 @default.
• W3197496434 hasAuthorship W3197496434A5013184354 @default.
• W3197496434 hasAuthorship W3197496434A5026971838 @default.
• W3197496434 hasAuthorship W3197496434A5041283916 @default.
• W3197496434 hasAuthorship W3197496434A5048993625 @default.
• W3197496434 hasBestOaLocation W31974964342 @default.
• W3197496434 hasConcept C112672928 @default.
• W3197496434 hasConcept C126322002 @default.
• W3197496434 hasConcept C144024400 @default.
• W3197496434 hasConcept C149923435 @default.
• W3197496434 hasConcept C2779234561 @default.
• W3197496434 hasConcept C2780221984 @default.
• W3197496434 hasConcept C2780586474 @default.
• W3197496434 hasConcept C511355011 @default.
• W3197496434 hasConcept C54355233 @default.
• W3197496434 hasConcept C71924100 @default.
• W3197496434 hasConcept C72563966 @default.
• W3197496434 hasConcept C77350462 @default.
• W3197496434 hasConcept C86803240 @default.
• W3197496434 hasConceptScore W3197496434C112672928 @default.
• W3197496434 hasConceptScore W3197496434C126322002 @default.
• W3197496434 hasConceptScore W3197496434C144024400 @default.
• W3197496434 hasConceptScore W3197496434C149923435 @default.
• W3197496434 hasConceptScore W3197496434C2779234561 @default.
• W3197496434 hasConceptScore W3197496434C2780221984 @default.
• W3197496434 hasConceptScore W3197496434C2780586474 @default.
• W3197496434 hasConceptScore W3197496434C511355011 @default.
• W3197496434 hasConceptScore W3197496434C54355233 @default.
• W3197496434 hasConceptScore W3197496434C71924100 @default.
• W3197496434 hasConceptScore W3197496434C72563966 @default.
• W3197496434 hasConceptScore W3197496434C77350462 @default.
• W3197496434 hasConceptScore W3197496434C86803240 @default.
• W3197496434 hasLocation W31974964341 @default.
• W3197496434 hasLocation W31974964342 @default.
• W3197496434 hasLocation W31974964343 @default.
• W3197496434 hasLocation W31974964344 @default.
• W3197496434 hasLocation W31974964345 @default.
• W3197496434 hasLocation W31974964346 @default.
• W3197496434 hasOpenAccess W3197496434 @default.
• W3197496434 hasPrimaryLocation W31974964341 @default.
• W3197496434 hasRelatedWork W2013490181 @default.
• W3197496434 hasRelatedWork W2041845756 @default.
• W3197496434 hasRelatedWork W2050831157 @default.
• W3197496434 hasRelatedWork W2095654789 @default.

• next