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• W3197552016 abstract "Abstract Aquired apraxia of speech is a disorder that impairs speech production, despite intact peripheral neuromotor function. Its pathomechanism remains to be established. Neurodegenerative lesion models provide an unequalled opportunity to explore the neural correlates of apraxia of speech, which is present in a subset of patients diagnosed with non-semantic variants of primary progressive aphasia. The normalized pairwise variability index, an acoustic measure of speech motor programming, has shown high sensitivity and specificity for apraxia of speech in cross-sectional studies. Here, we aimed to examine the strength of the pairwise variability index and overall word duration (i.e. articulation rate) as markers of progressive motor programming deficits in primary progressive aphasia with apraxia of speech. Seventy-nine individuals diagnosed with primary progressive aphasia (39 with non-fluent variant and 40 with logopenic variant) and 40 matched healthy controls participated. Patients were followed-up annually (range 1–6 years, median number of visits = 2). All participants completed a speech assessment task and a high-resolution MRI. Our analyses investigated trajectories of speech production (e.g. pairwise variablity index and word duration) and associations with cortical atrophy in the patients. At first presentation, word duration differentiated the nonfluent and logopenic cases statistically, but the range of scores overlapped substantially across groups. Longitudinally, we observed progressive deterioration in pairwise variability index and word duration specific to the non-fluent group only. The pairwise variability index showed particularly strong associations with progressive atrophy in speech motor programming brain regions. Of novelty, our results uncovered a key role of the right frontal gyrus in underpinning speech motor programming changes in non-fluent cases, highlighting the importance of right-brain regions in responding to progressive neurological changes in the speech motor network. Taken together, our findings validate the use of a new metric, the pairwise variability index, as a robust marker of apraxia of speech in contrast to more generic measures of speaking rate. Sensitive/specific neuroimaging biomarkers of the emergence and progression of speech impairments will be useful to inform theories of the pathomechanisms underpinning impaired speech motor control. Our findings justify developing more sensitive measures of rhythmic temporal control of speech that may enable confident detection of emerging speech disturbances and more sensitive tracking of intervention-related changes for pharmacological, neuromodulatory and behavioural interventions. A more reliable detection of speech disturbances has relevance for patient care, with predominance of progressive apraxia of speech a high-risk factor for later diagnosis of progressive supranuclear palsy or corticobasal degeneration." @default.
• W3197552016 created "2021-09-13" @default.
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• W3197552016 date "2021-01-01" @default.
• W3197552016 modified "2023-10-11" @default.
• W3197552016 title "Brain changes underlying progression of speech motor programming impairment" @default.
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• W3197552016 cites W1603839143 @default.
• W3197552016 cites W1811518384 @default.
• W3197552016 cites W1966848686 @default.
• W3197552016 cites W1971707725 @default.
• W3197552016 cites W1980142605 @default.
• W3197552016 cites W1981056670 @default.
• W3197552016 cites W1984623724 @default.
• W3197552016 cites W1991952617 @default.
• W3197552016 cites W1999887188 @default.
• W3197552016 cites W2010681077 @default.
• W3197552016 cites W2012763181 @default.
• W3197552016 cites W2015151082 @default.
• W3197552016 cites W2018601219 @default.
• W3197552016 cites W2021414544 @default.
• W3197552016 cites W2033777670 @default.
• W3197552016 cites W2034402014 @default.
• W3197552016 cites W2035771001 @default.
• W3197552016 cites W2040005370 @default.
• W3197552016 cites W2043113070 @default.
• W3197552016 cites W2046616378 @default.
• W3197552016 cites W2054159854 @default.
• W3197552016 cites W2058161128 @default.
• W3197552016 cites W2059824090 @default.
• W3197552016 cites W2068520467 @default.
• W3197552016 cites W2073254356 @default.
• W3197552016 cites W2076068537 @default.
• W3197552016 cites W2082371487 @default.
• W3197552016 cites W2091792980 @default.
• W3197552016 cites W2097396111 @default.
• W3197552016 cites W2098108064 @default.
• W3197552016 cites W2103481737 @default.
• W3197552016 cites W2105991991 @default.
• W3197552016 cites W2109170547 @default.
• W3197552016 cites W2110208125 @default.
• W3197552016 cites W2110437310 @default.
• W3197552016 cites W2114315159 @default.
• W3197552016 cites W2117101773 @default.
• W3197552016 cites W2123692283 @default.
• W3197552016 cites W2132114367 @default.
• W3197552016 cites W2135496343 @default.
• W3197552016 cites W2138190873 @default.
• W3197552016 cites W2139886607 @default.
• W3197552016 cites W2142864721 @default.
• W3197552016 cites W2143342735 @default.
• W3197552016 cites W2151721316 @default.
• W3197552016 cites W2157296433 @default.
• W3197552016 cites W2161762785 @default.
• W3197552016 cites W2200247130 @default.
• W3197552016 cites W2255896522 @default.
• W3197552016 cites W2272468257 @default.
• W3197552016 cites W2309633614 @default.
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• W3197552016 cites W255785398 @default.
• W3197552016 cites W2580210409 @default.
• W3197552016 cites W2586883179 @default.
• W3197552016 cites W2625796101 @default.
• W3197552016 cites W2769915335 @default.
• W3197552016 cites W2770242043 @default.
• W3197552016 cites W2800976177 @default.
• W3197552016 cites W2889659664 @default.
• W3197552016 cites W2894273961 @default.
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• W3197552016 doi "https://doi.org/10.1093/braincomms/fcab205" @default.
• W3197552016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8445394" @default.
• W3197552016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34541532" @default.
• W3197552016 hasPublicationYear "2021" @default.
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