FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197599826> ?p ?o ?g. }

• W3197599826 endingPage "e0255672" @default.
• W3197599826 startingPage "e0255672" @default.
• W3197599826 abstract "Background/aim We investigated alterations in the expression of serum exosomal miRNAs with the progression of liver fibrosis and evaluated their clinical applicability as biomarkers. Methods This study prospectively enrolled 71 patients who underwent liver biopsy at an academic hospital in Korea. Exosomes were extracted from serum samples, followed by next-generation sequencing (NGS) of miRNAs and targeted real-time quantitative polymerase chain reaction. A model was derived to discriminate advanced fibrosis based on miRNA levels and the performance of this model was evaluated. Validation of the effect of miRNA on liver fibrosis in vitro was followed. Results NGS data revealed that exosomal miR-660-5p, miR-125a-5p, and miR-122 expression were changed significantly with the progression of liver fibrosis, of which miR-122 exhibited high read counts enough to be used as a biomarker. The level of exosomal miR-122 decreased as the pathologic fibrosis grade progressed and patients with biopsy-proven advanced fibrosis had significantly lower levels of exosomal miR-122 ( P < 0.001) than those without advanced fibrosis. Exosomal miR-122 exhibited a fair performance in discriminating advanced fibrosis especially in combination with fibrosis-4 score and transient elastography. In a subgroup of patients with a non-viral etiology of liver disease, the performance of exosomal miR-122 as a biomarker was greatly improved. Inhibition of miR-122 expression increased the proliferation of the human hepatic stellate cell line, LX-2, and upregulated the expression of various fibrosis related proteins. Conclusion Exosomal miR-122 may serve as a useful non-invasive biomarker for liver fibrosis, especially in patients with non-viral etiologies of chronic liver disease." @default.
• W3197599826 created "2021-09-13" @default.
• W3197599826 creator A5016036005 @default.
• W3197599826 creator A5023172993 @default.
• W3197599826 creator A5024533298 @default.
• W3197599826 creator A5036816797 @default.
• W3197599826 creator A5051951378 @default.
• W3197599826 creator A5056494034 @default.
• W3197599826 creator A5057447649 @default.
• W3197599826 creator A5061046727 @default.
• W3197599826 creator A5065876999 @default.
• W3197599826 creator A5066653815 @default.
• W3197599826 creator A5068466255 @default.
• W3197599826 creator A5072844970 @default.
• W3197599826 creator A5076446308 @default.
• W3197599826 creator A5083728536 @default.
• W3197599826 date "2021-09-10" @default.
• W3197599826 modified "2023-10-11" @default.
• W3197599826 title "Clinical impact of serum exosomal microRNA in liver fibrosis" @default.
• W3197599826 cites W1599780637 @default.
• W3197599826 cites W1717937800 @default.
• W3197599826 cites W1840988451 @default.
• W3197599826 cites W1873432586 @default.
• W3197599826 cites W1923097273 @default.
• W3197599826 cites W1976628534 @default.
• W3197599826 cites W1977829284 @default.
• W3197599826 cites W1981420342 @default.
• W3197599826 cites W1984469930 @default.
• W3197599826 cites W1985928588 @default.
• W3197599826 cites W1989277040 @default.
• W3197599826 cites W1997865776 @default.
• W3197599826 cites W1999787016 @default.
• W3197599826 cites W2009371120 @default.
• W3197599826 cites W2010549748 @default.
• W3197599826 cites W2017857120 @default.
• W3197599826 cites W2022687771 @default.
• W3197599826 cites W2028897685 @default.
• W3197599826 cites W2029426792 @default.
• W3197599826 cites W2043837788 @default.
• W3197599826 cites W2055313665 @default.
• W3197599826 cites W2059357290 @default.
• W3197599826 cites W2062410076 @default.
• W3197599826 cites W2064227724 @default.
• W3197599826 cites W2064387090 @default.
• W3197599826 cites W2075539598 @default.
• W3197599826 cites W2086719465 @default.
• W3197599826 cites W2092233471 @default.
• W3197599826 cites W2093478617 @default.
• W3197599826 cites W2099369804 @default.
• W3197599826 cites W2099628752 @default.
• W3197599826 cites W2114202720 @default.
• W3197599826 cites W2115754362 @default.
• W3197599826 cites W2121354606 @default.
• W3197599826 cites W2143053936 @default.
• W3197599826 cites W2145818453 @default.
• W3197599826 cites W2147526777 @default.
• W3197599826 cites W2147934487 @default.
• W3197599826 cites W2154985027 @default.
• W3197599826 cites W2159114297 @default.
• W3197599826 cites W2159767268 @default.
• W3197599826 cites W2164960736 @default.
• W3197599826 cites W2194650612 @default.
• W3197599826 cites W2213848118 @default.
• W3197599826 cites W2298244104 @default.
• W3197599826 cites W2416448252 @default.
• W3197599826 cites W2588096571 @default.
• W3197599826 cites W2610239039 @default.
• W3197599826 cites W2699220065 @default.
• W3197599826 cites W2746549636 @default.
• W3197599826 cites W2767283540 @default.
• W3197599826 cites W2896739292 @default.
• W3197599826 cites W2965246344 @default.
• W3197599826 doi "https://doi.org/10.1371/journal.pone.0255672" @default.
• W3197599826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8432846" @default.
• W3197599826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34506494" @default.
• W3197599826 hasPublicationYear "2021" @default.
• W3197599826 type Work @default.
• W3197599826 sameAs 3197599826 @default.
• W3197599826 citedByCount "11" @default.
• W3197599826 countsByYear W31975998262022 @default.
• W3197599826 countsByYear W31975998262023 @default.
• W3197599826 crossrefType "journal-article" @default.
• W3197599826 hasAuthorship W3197599826A5016036005 @default.
• W3197599826 hasAuthorship W3197599826A5023172993 @default.
• W3197599826 hasAuthorship W3197599826A5024533298 @default.
• W3197599826 hasAuthorship W3197599826A5036816797 @default.
• W3197599826 hasAuthorship W3197599826A5051951378 @default.
• W3197599826 hasAuthorship W3197599826A5056494034 @default.
• W3197599826 hasAuthorship W3197599826A5057447649 @default.
• W3197599826 hasAuthorship W3197599826A5061046727 @default.
• W3197599826 hasAuthorship W3197599826A5065876999 @default.
• W3197599826 hasAuthorship W3197599826A5066653815 @default.
• W3197599826 hasAuthorship W3197599826A5068466255 @default.
• W3197599826 hasAuthorship W3197599826A5072844970 @default.
• W3197599826 hasAuthorship W3197599826A5076446308 @default.
• W3197599826 hasAuthorship W3197599826A5083728536 @default.
• W3197599826 hasBestOaLocation W31975998261 @default.
• W3197599826 hasConcept C104317684 @default.

• next