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- W3197662015 abstract "The Interleukin (LL)-17 plays a crucial role in the invasion of tumors. However, the effects of IL-17 on the invasion of human pituitary adenomas are still unknown. The current study is designed to investigate the possible involvement of IL-17 in the invasion of adenomas. By collecting invasive and non-invasive pituitary adenomas, the mRNA and protein level of IL-17 and Matrix metallopeptidase (MMP)-9 is investigated. The results obtained from immunohistochemistry (IHC) showed that the strong positive rate and total positive rate of IL-17 and MMP-9 in invasive group were significantly higher than that of non-invasive group. Meanwhile serum IL-17 level in invasive pituitary adenomas patients was significantly higher than non-invasive groups (p < 0.05). Furthermore, the mRNA levels of IL-17 and MMP-9 were also higher in invasive group than in non-invasive group with statistical differences (p < 0.05), and the expression level of IL-17 were positive correlated with that of MMP-9 in invasive group, but not in non-invasive group. These results suggested that IL 17 may promote the invasion of pituitary adenomas." @default.
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- W3197662015 date "2010-01-01" @default.
- W3197662015 modified "2023-09-24" @default.
- W3197662015 title "The Interleukin (IL)-17 is Involved in Invasion of Human Pituitary Adenomas" @default.
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