Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197681803> ?p ?o ?g. }
- W3197681803 abstract "The activity of epiphyseal growth plates, which drives long bone elongation, depends on extensive changes in chondrocyte size and shape during differentiation. Here, we develop a pipeline called 3D Morphometric Analysis for Phenotypic significance (3D MAPs), which combines light-sheet microscopy, segmentation algorithms and 3D morphometric analysis to characterize morphogenetic cellular behaviors while maintaining the spatial context of the growth plate. Using 3D MAPs, we create a 3D image database of hundreds of thousands of chondrocytes. Analysis reveals broad repertoire of morphological changes, growth strategies and cell organizations during differentiation. Moreover, identifying a reduction in Smad 1/5/9 activity together with multiple abnormalities in cell growth, shape and organization provides an explanation for the shortening of Gdf5 KO tibias. Overall, our findings provide insight into the morphological sequence that chondrocytes undergo during differentiation and highlight the ability of 3D MAPs to uncover cellular mechanisms that may regulate this process." @default.
- W3197681803 created "2021-09-13" @default.
- W3197681803 creator A5004659592 @default.
- W3197681803 creator A5014018022 @default.
- W3197681803 creator A5021791598 @default.
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- W3197681803 creator A5057786365 @default.
- W3197681803 creator A5059757659 @default.
- W3197681803 creator A5062748514 @default.
- W3197681803 creator A5076337424 @default.
- W3197681803 creator A5081367646 @default.
- W3197681803 creator A5082049684 @default.
- W3197681803 date "2021-09-10" @default.
- W3197681803 modified "2023-09-30" @default.
- W3197681803 title "Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process" @default.
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