Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197702414> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3197702414 endingPage "e377101119640" @default.
- W3197702414 startingPage "e377101119640" @default.
- W3197702414 abstract "The objective of this study was to validate an analytical technique with HPLC-PDA for plasma measurement of carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CBZ-E) for therapeutic monitoring (TM) of patients diagnosed with bipolar disorder (BD), as well as evaluating hematological and biochemical parameters of patients using CBZ. Sixteen patients registered with the Public Service of Psychiatry were selected. CBZ and CBZ-E measurements were performed with HPLC-PDA shimadzu LC-20 AT Prominence, under concentration gradient. Validation criteria: selectivity, linearity, precision, accuracy, recovery, stability. Hematological and biochemical tests were performed using conventional methods. As a result, it was obtained: accuracy >85% and precision <15%, good selectivity, robustness and stability, LOQ = 250 ng.mL-1 and HQL = 60,000 ng.mL-1. Among patients, 25% and 6.25% had CBZ and CBZ-E levels within the therapeutic range, respectively. There were hematological and biochemical changes related to the drug. The validated method is reliable for its intended purpose. TM proved to be extremely useful for detecting therapeutic failure." @default.
- W3197702414 created "2021-09-13" @default.
- W3197702414 creator A5006153161 @default.
- W3197702414 creator A5013605867 @default.
- W3197702414 creator A5040175925 @default.
- W3197702414 creator A5061995673 @default.
- W3197702414 creator A5062136323 @default.
- W3197702414 creator A5063679348 @default.
- W3197702414 creator A5085801764 @default.
- W3197702414 creator A5086474433 @default.
- W3197702414 date "2021-09-04" @default.
- W3197702414 modified "2023-10-18" @default.
- W3197702414 title "Carbamazepine and carbamazepine-10, 11-epoxide therapeutic drug monitoring and biochemical and hematological evaluation in bipolar disorder outpatients" @default.
- W3197702414 cites W1577772485 @default.
- W3197702414 cites W2016503778 @default.
- W3197702414 cites W2024322605 @default.
- W3197702414 cites W2037143259 @default.
- W3197702414 cites W2068359122 @default.
- W3197702414 cites W2140914231 @default.
- W3197702414 cites W2752156190 @default.
- W3197702414 cites W2787114907 @default.
- W3197702414 cites W2788627490 @default.
- W3197702414 cites W2887254373 @default.
- W3197702414 cites W2891289930 @default.
- W3197702414 cites W2897609791 @default.
- W3197702414 cites W2898604952 @default.
- W3197702414 cites W3134891749 @default.
- W3197702414 cites W3171597527 @default.
- W3197702414 cites W3186354030 @default.
- W3197702414 doi "https://doi.org/10.33448/rsd-v10i11.19640" @default.
- W3197702414 hasPublicationYear "2021" @default.
- W3197702414 type Work @default.
- W3197702414 sameAs 3197702414 @default.
- W3197702414 citedByCount "0" @default.
- W3197702414 crossrefType "journal-article" @default.
- W3197702414 hasAuthorship W3197702414A5006153161 @default.
- W3197702414 hasAuthorship W3197702414A5013605867 @default.
- W3197702414 hasAuthorship W3197702414A5040175925 @default.
- W3197702414 hasAuthorship W3197702414A5061995673 @default.
- W3197702414 hasAuthorship W3197702414A5062136323 @default.
- W3197702414 hasAuthorship W3197702414A5063679348 @default.
- W3197702414 hasAuthorship W3197702414A5085801764 @default.
- W3197702414 hasAuthorship W3197702414A5086474433 @default.
- W3197702414 hasBestOaLocation W31977024141 @default.
- W3197702414 hasConcept C118552586 @default.
- W3197702414 hasConcept C126322002 @default.
- W3197702414 hasConcept C149151106 @default.
- W3197702414 hasConcept C185592680 @default.
- W3197702414 hasConcept C19831878 @default.
- W3197702414 hasConcept C2776174506 @default.
- W3197702414 hasConcept C2777477808 @default.
- W3197702414 hasConcept C2778186239 @default.
- W3197702414 hasConcept C2778541603 @default.
- W3197702414 hasConcept C2779253243 @default.
- W3197702414 hasConcept C2780035454 @default.
- W3197702414 hasConcept C2780272996 @default.
- W3197702414 hasConcept C43617362 @default.
- W3197702414 hasConcept C71924100 @default.
- W3197702414 hasConcept C98274493 @default.
- W3197702414 hasConceptScore W3197702414C118552586 @default.
- W3197702414 hasConceptScore W3197702414C126322002 @default.
- W3197702414 hasConceptScore W3197702414C149151106 @default.
- W3197702414 hasConceptScore W3197702414C185592680 @default.
- W3197702414 hasConceptScore W3197702414C19831878 @default.
- W3197702414 hasConceptScore W3197702414C2776174506 @default.
- W3197702414 hasConceptScore W3197702414C2777477808 @default.
- W3197702414 hasConceptScore W3197702414C2778186239 @default.
- W3197702414 hasConceptScore W3197702414C2778541603 @default.
- W3197702414 hasConceptScore W3197702414C2779253243 @default.
- W3197702414 hasConceptScore W3197702414C2780035454 @default.
- W3197702414 hasConceptScore W3197702414C2780272996 @default.
- W3197702414 hasConceptScore W3197702414C43617362 @default.
- W3197702414 hasConceptScore W3197702414C71924100 @default.
- W3197702414 hasConceptScore W3197702414C98274493 @default.
- W3197702414 hasIssue "11" @default.
- W3197702414 hasLocation W31977024141 @default.
- W3197702414 hasOpenAccess W3197702414 @default.
- W3197702414 hasPrimaryLocation W31977024141 @default.
- W3197702414 hasRelatedWork W12755166 @default.
- W3197702414 hasRelatedWork W2157544 @default.
- W3197702414 hasRelatedWork W3266514 @default.
- W3197702414 hasRelatedWork W3624395 @default.
- W3197702414 hasRelatedWork W6063589 @default.
- W3197702414 hasRelatedWork W6784274 @default.
- W3197702414 hasRelatedWork W6907002 @default.
- W3197702414 hasRelatedWork W8819352 @default.
- W3197702414 hasRelatedWork W9458 @default.
- W3197702414 hasRelatedWork W9954624 @default.
- W3197702414 hasVolume "10" @default.
- W3197702414 isParatext "false" @default.
- W3197702414 isRetracted "false" @default.
- W3197702414 magId "3197702414" @default.
- W3197702414 workType "article" @default.