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- W3197708756 abstract "We mainly corroborated the potential mechanism of DLX1 and miR-129-5p in prostate cancer cells. DLX1 was upregulated in cancer cells according to qRT-PCR assay. We evaluated the functional changes of the transfected cells via Transwell assay, CCK-8 assay and wound healing assay. DLX1 was confirmed as a cancer promoter. In addition, qRT-PCR showed down-regulated miR-129-5p expression in prostate cancer. We further used dual-luciferase reporter detection to elucidate the targeting between these two genes. The inhibition of miR-129-5p on tumour was verified. Besides, co-transfection of oe-DLX1 and miR-129-5p mimics attenuated this inhibition. These data demonstrated functions of DLX1/miR-129-5p axis in prostate cancer: miR-129-5p hindered the biological functions of cancer cells via inhibiting DLX1 expression. We provide a novel biomarker for prostate cancer." @default.
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- W3197708756 date "2021-09-01" @default.
- W3197708756 modified "2023-09-29" @default.
- W3197708756 title "MiR‐129‐5p/DLX1 signalling axis mediates functions of prostate cancer during malignant progression" @default.
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- W3197708756 doi "https://doi.org/10.1111/and.14230" @default.
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