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- W3197750156 abstract "Objective Primate studies have shown that bovine and porcine heparins dosed at equivalent anti-Xa units produce equivalent anti-IIa and anti-Xa responses in vivo. Heparin’s pharmacokinetic behavior is typically based on antithrombin (AT)-dependent anti-Xa and anti-IIa activities. Heparin Red is a polycationic substance whose intrinsic fluorescence is quenched upon binding to heparin. Assays utilizing Heparin Red detect heparin oligosaccharides that bind to AT and those that do not. Non-AT binding heparin oligosaccharides can impact coagulation through their interaction with heparin cofactor II, TFPI and platelets. Thus, the pharmacokinetic behavior of heparin as determined using a Heparin Red assay may more closely reflect the clinical behavior of heparin than pharmacodynamic measures where heparin levels are determined based only on AT-dependent activities." @default.
- W3197750156 created "2021-09-13" @default.
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- W3197750156 date "2021-06-01" @default.
- W3197750156 modified "2023-09-26" @default.
- W3197750156 title "Quantification of Bovine and Porcine Heparin Red Assay Utilizing the Heparin Red Assay. Applications in the Study of Pharmacokinetics and Pharmacodynamics." @default.
- W3197750156 doi "https://doi.org/10.1055/s-0041-1728176" @default.
- W3197750156 hasPublicationYear "2021" @default.
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