FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197752606> ?p ?o ?g. }

• W3197752606 endingPage "898" @default.
• W3197752606 startingPage "898" @default.
• W3197752606 abstract "Background and Objectives: Gouty arthritis is an acute inflammatory response caused by the precipitation of monosodium urate (MSU) crystals in joints. The triggering of MSU leads to increased production of inflammatory cytokines, such as interleukin-1β, which in turn lead to the formation of macromolecular complexes, referred to as inflammasomes. Thorough characterization of the NLRP3 inflammasome can be used as an indicator of an immune response against harmful stimuli. Cardamonin is a chalcone, mainly found in the seeds of Alpinia katsumadai, and exhibits anti-inflammatory activity by inhibiting the release of pro-inflammatory cytokines in vitro. However, the mechanism by which cardamonin treatment alleviates gouty arthritis has yet to be fully elucidated. Materials and Methods: In vitro or in vivo models were used to study whether cardamonimn inhibited NLRP3 inflammasome activation or suppressed gouty inflammation. Results: In the current study, we determined that most NLRP3 was released passively after MSU stimulation, and this release of NLRP3 promoted caspase-1 activation and IL-1β secretion. Cardamonin was shown to decrease both the activity of caspase-1 and secretion of IL-1β in J774A.1 macrophage cells subjected to MSU stimulation. Cardamonin was also shown to attenuate the production of COX-2 in MSU-stimulated J774A.1 macrophage cells. Finally, cardamonin reduced the thickness of the synovial lining and the infiltration of gouty arthritis in a rat model. Conclusions: Overall, cardamonin significantly attenuated IL-1β secretion, caspase-1 activity, and COX-2 production stimulated by MSU. These findings provide new insights into the molecular mechanisms underlying the effects of cardamonin treatment for gouty arthritis." @default.
• W3197752606 created "2021-09-13" @default.
• W3197752606 creator A5005003565 @default.
• W3197752606 creator A5009656964 @default.
• W3197752606 creator A5030532302 @default.
• W3197752606 creator A5053985678 @default.
• W3197752606 creator A5060302820 @default.
• W3197752606 creator A5063841543 @default.
• W3197752606 creator A5075294636 @default.
• W3197752606 creator A5082691106 @default.
• W3197752606 creator A5085953543 @default.
• W3197752606 creator A5086193266 @default.
• W3197752606 date "2021-08-28" @default.
• W3197752606 modified "2023-10-12" @default.
• W3197752606 title "Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation" @default.
• W3197752606 cites W1518143481 @default.
• W3197752606 cites W1546854828 @default.
• W3197752606 cites W1553158606 @default.
• W3197752606 cites W1636793459 @default.
• W3197752606 cites W1860160715 @default.
• W3197752606 cites W1975555032 @default.
• W3197752606 cites W1984876037 @default.
• W3197752606 cites W1988190590 @default.
• W3197752606 cites W2003257415 @default.
• W3197752606 cites W2009800174 @default.
• W3197752606 cites W2011392312 @default.
• W3197752606 cites W2014301861 @default.
• W3197752606 cites W2038676766 @default.
• W3197752606 cites W2081826468 @default.
• W3197752606 cites W2104475738 @default.
• W3197752606 cites W2110765723 @default.
• W3197752606 cites W2126111624 @default.
• W3197752606 cites W2129935236 @default.
• W3197752606 cites W2140637559 @default.
• W3197752606 cites W2143119237 @default.
• W3197752606 cites W2167795966 @default.
• W3197752606 cites W2173069051 @default.
• W3197752606 cites W2197043200 @default.
• W3197752606 cites W2287534317 @default.
• W3197752606 cites W2549497080 @default.
• W3197752606 cites W2750561124 @default.
• W3197752606 cites W2754485818 @default.
• W3197752606 cites W2766374923 @default.
• W3197752606 cites W2889343095 @default.
• W3197752606 cites W2911549495 @default.
• W3197752606 cites W2912208837 @default.
• W3197752606 cites W2913845592 @default.
• W3197752606 cites W2940523644 @default.
• W3197752606 cites W2943293743 @default.
• W3197752606 cites W2982061867 @default.
• W3197752606 cites W3012442527 @default.
• W3197752606 cites W3023256684 @default.
• W3197752606 cites W3041532002 @default.
• W3197752606 cites W3091947140 @default.
• W3197752606 cites W3165239352 @default.
• W3197752606 doi "https://doi.org/10.3390/medicina57090898" @default.
• W3197752606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8471485" @default.
• W3197752606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34577821" @default.
• W3197752606 hasPublicationYear "2021" @default.
• W3197752606 type Work @default.
• W3197752606 sameAs 3197752606 @default.
• W3197752606 citedByCount "6" @default.
• W3197752606 countsByYear W31977526062022 @default.
• W3197752606 countsByYear W31977526062023 @default.
• W3197752606 crossrefType "journal-article" @default.
• W3197752606 hasAuthorship W3197752606A5005003565 @default.
• W3197752606 hasAuthorship W3197752606A5009656964 @default.
• W3197752606 hasAuthorship W3197752606A5030532302 @default.
• W3197752606 hasAuthorship W3197752606A5053985678 @default.
• W3197752606 hasAuthorship W3197752606A5060302820 @default.
• W3197752606 hasAuthorship W3197752606A5063841543 @default.
• W3197752606 hasAuthorship W3197752606A5075294636 @default.
• W3197752606 hasAuthorship W3197752606A5082691106 @default.
• W3197752606 hasAuthorship W3197752606A5085953543 @default.
• W3197752606 hasAuthorship W3197752606A5086193266 @default.
• W3197752606 hasBestOaLocation W31977526061 @default.
• W3197752606 hasConcept C126322002 @default.
• W3197752606 hasConcept C139964883 @default.
• W3197752606 hasConcept C150903083 @default.
• W3197752606 hasConcept C164027704 @default.
• W3197752606 hasConcept C185592680 @default.
• W3197752606 hasConcept C203014093 @default.
• W3197752606 hasConcept C207001950 @default.
• W3197752606 hasConcept C24998067 @default.
• W3197752606 hasConcept C2776914184 @default.
• W3197752606 hasConcept C2777077863 @default.
• W3197752606 hasConcept C2777209026 @default.
• W3197752606 hasConcept C49039625 @default.
• W3197752606 hasConcept C55493867 @default.
• W3197752606 hasConcept C71924100 @default.
• W3197752606 hasConcept C86803240 @default.
• W3197752606 hasConcept C98274493 @default.
• W3197752606 hasConceptScore W3197752606C126322002 @default.
• W3197752606 hasConceptScore W3197752606C139964883 @default.
• W3197752606 hasConceptScore W3197752606C150903083 @default.
• W3197752606 hasConceptScore W3197752606C164027704 @default.
• W3197752606 hasConceptScore W3197752606C185592680 @default.
• W3197752606 hasConceptScore W3197752606C203014093 @default.

• next