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- W3197753516 abstract "As drugs that target the DNA repair pathway with synthetic lethality play an increasingly important role in the treatment of ovarian cancer [1], poly-ADP ribose polymerase (PARP) inhibitors have been incorporated into clinical practice in the maintenance setting after initial treatment or after treatment of platinum-sensitive recurrent disease [2]. Although rare, myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) have been associated with PARP inhibitor therapy [3–6]. A recent safety meta-analysis of 28 clinical trials showed the incidence of MDS or AML was 0.73% in the women who received PARP inhibitors versus 0.47% for the placebo group [3]." @default.
- W3197753516 created "2021-09-13" @default.
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- W3197753516 date "2021-11-01" @default.
- W3197753516 modified "2023-10-10" @default.
- W3197753516 title "Secondary haematologic malignancies in women with ovarian cancer receiving poly-ADP ribose polymerase inhibitor therapy." @default.
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- W3197753516 doi "https://doi.org/10.1016/j.ejca.2021.08.016" @default.
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