FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197769891> ?p ?o ?g. }

• W3197769891 endingPage "915" @default.
• W3197769891 startingPage "915" @default.
• W3197769891 abstract "Epithelial cell-activating molecule (EpCAM) is an important cancer biomarker and therapeutic target given its elevated expression in epithelial cancers. EpCAM is a type I transmembrane protein that forms cis-dimers along the thyroglobulin type-1A-like domain (TYD) in the extracellular region. The thyroglobulin loop (TY loop) within the TYD is structurally dynamic in the monomer state of human EpCAM, binding reversibly to a TYD site. However, it is not known if this flexibility is prevalent across different species. Here, we conduct over 17 μs of all-atom molecular dynamics simulations to study EpCAM TY loop kinetics of five different species, including human, mouse, chicken, frog, and fish. We find that the TY loop remains dynamic across evolution. In addition to the TYD binding site, we discover a second binding site for the TY loop in the C-terminal domain (CTD). Calculations of the dissociation rate constants from the simulation trajectories suggest a differential binding pattern of fish EpCAM and other organisms. Whereas fish TY loop has comparable binding for both TYD and CTD sites, the TY loops of other species preferably bind the TYD site. A hybrid construct of fish EpCAM with human TY loop restores the TYD binding preference, suggesting robust effects of the TY loop sequence on its dynamic behavior. Our findings provide insights into the structural dynamics of EpCAM and its implication in physiological functions." @default.
• W3197769891 created "2021-09-13" @default.
• W3197769891 creator A5008582056 @default.
• W3197769891 creator A5067386214 @default.
• W3197769891 date "2021-09-03" @default.
• W3197769891 modified "2023-09-30" @default.
• W3197769891 title "Evolution of Thyroglobulin Loop Kinetics in EpCAM" @default.
• W3197769891 cites W1971523929 @default.
• W3197769891 cites W1975537268 @default.
• W3197769891 cites W1976499671 @default.
• W3197769891 cites W1986978780 @default.
• W3197769891 cites W2029667189 @default.
• W3197769891 cites W2037150116 @default.
• W3197769891 cites W2044689258 @default.
• W3197769891 cites W2055107026 @default.
• W3197769891 cites W2065283382 @default.
• W3197769891 cites W2067174909 @default.
• W3197769891 cites W2084492403 @default.
• W3197769891 cites W2092032317 @default.
• W3197769891 cites W2111271799 @default.
• W3197769891 cites W2138249379 @default.
• W3197769891 cites W2141787031 @default.
• W3197769891 cites W2154767456 @default.
• W3197769891 cites W2218722424 @default.
• W3197769891 cites W2555870966 @default.
• W3197769891 cites W2621922190 @default.
• W3197769891 cites W2770317270 @default.
• W3197769891 cites W2800697076 @default.
• W3197769891 cites W2858268852 @default.
• W3197769891 cites W2889277487 @default.
• W3197769891 cites W2893330401 @default.
• W3197769891 cites W2953344451 @default.
• W3197769891 cites W3010138368 @default.
• W3197769891 cites W3015083259 @default.
• W3197769891 cites W3030271176 @default.
• W3197769891 cites W3033457790 @default.
• W3197769891 cites W3046751266 @default.
• W3197769891 cites W3107775148 @default.
• W3197769891 cites W3119787642 @default.
• W3197769891 cites W3136994097 @default.
• W3197769891 cites W3137831693 @default.
• W3197769891 cites W3165844287 @default.
• W3197769891 cites W3190382703 @default.
• W3197769891 doi "https://doi.org/10.3390/life11090915" @default.
• W3197769891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8467770" @default.
• W3197769891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34575064" @default.
• W3197769891 hasPublicationYear "2021" @default.
• W3197769891 type Work @default.
• W3197769891 sameAs 3197769891 @default.
• W3197769891 citedByCount "3" @default.
• W3197769891 countsByYear W31977698912022 @default.
• W3197769891 countsByYear W31977698912023 @default.
• W3197769891 crossrefType "journal-article" @default.
• W3197769891 hasAuthorship W3197769891A5008582056 @default.
• W3197769891 hasAuthorship W3197769891A5067386214 @default.
• W3197769891 hasBestOaLocation W31977698911 @default.
• W3197769891 hasConcept C121332964 @default.
• W3197769891 hasConcept C12554922 @default.
• W3197769891 hasConcept C148898269 @default.
• W3197769891 hasConcept C170493617 @default.
• W3197769891 hasConcept C185592680 @default.
• W3197769891 hasConcept C24530287 @default.
• W3197769891 hasConcept C55493867 @default.
• W3197769891 hasConcept C62520636 @default.
• W3197769891 hasConcept C86803240 @default.
• W3197769891 hasConcept C95444343 @default.
• W3197769891 hasConceptScore W3197769891C121332964 @default.
• W3197769891 hasConceptScore W3197769891C12554922 @default.
• W3197769891 hasConceptScore W3197769891C148898269 @default.
• W3197769891 hasConceptScore W3197769891C170493617 @default.
• W3197769891 hasConceptScore W3197769891C185592680 @default.
• W3197769891 hasConceptScore W3197769891C24530287 @default.
• W3197769891 hasConceptScore W3197769891C55493867 @default.
• W3197769891 hasConceptScore W3197769891C62520636 @default.
• W3197769891 hasConceptScore W3197769891C86803240 @default.
• W3197769891 hasConceptScore W3197769891C95444343 @default.
• W3197769891 hasFunder F4320306084 @default.
• W3197769891 hasIssue "9" @default.
• W3197769891 hasLocation W31977698911 @default.
• W3197769891 hasLocation W31977698912 @default.
• W3197769891 hasLocation W31977698913 @default.
• W3197769891 hasLocation W31977698914 @default.
• W3197769891 hasLocation W31977698915 @default.
• W3197769891 hasLocation W31977698916 @default.
• W3197769891 hasOpenAccess W3197769891 @default.
• W3197769891 hasPrimaryLocation W31977698911 @default.
• W3197769891 hasRelatedWork W117413764 @default.
• W3197769891 hasRelatedWork W1975279219 @default.
• W3197769891 hasRelatedWork W1998741829 @default.
• W3197769891 hasRelatedWork W2015731959 @default.
• W3197769891 hasRelatedWork W2088431388 @default.
• W3197769891 hasRelatedWork W2102472951 @default.
• W3197769891 hasRelatedWork W2914062963 @default.
• W3197769891 hasRelatedWork W2952110918 @default.
• W3197769891 hasRelatedWork W3088305668 @default.
• W3197769891 hasRelatedWork W3138279926 @default.
• W3197769891 hasVolume "11" @default.
• W3197769891 isParatext "false" @default.

• next