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- W3197775189 abstract "Obesity-mediated metabolic syndrome remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising strategy involves the heme oxygenase (HO) system, specifically its inducible form, HO-1. This review collects and updates much of the current knowledge relevant to pharmacology and clinical medicine concerning HO-1 in metabolic diseases and its effect on lipid metabolism. HO-1 has pleotropic effects that collectively reduce inflammation, while increasing vasodilation and insulin and leptin sensitivity. Recent reports indicate that HO-1 with its antioxidants via the effect of bilirubin increases formation of biologically active lipid metabolites such as epoxyeicosatrienoic acid (EET), omega-3 and other polyunsaturated fatty acids (PUFAs). Similarly, HO-1and bilirubin are potential therapeutic targets in the treatment of fat-induced liver diseases. HO-1-mediated upregulation of EET is capable not only of reversing endothelial dysfunction and hypertension, but also of reversing cardiac remodeling, a hallmark of the metabolic syndrome. This process involves browning of white fat tissue (i.e. formation of healthy adipocytes) and reduced lipotoxicity, which otherwise will be toxic to the heart. More importantly, this review examines the activity of EET in biological systems and a series of pathways that explain its mechanism of action and discusses how these might be exploited for potential therapeutic use. We also discuss the link between cardiac ectopic fat deposition and cardiac function in humans, which is similar to that described in obese mice and is regulated by HO-1-EET-PGC1α signaling, a potent negative regulator of the inflammatory adipokine NOV." @default.
- W3197775189 created "2021-09-13" @default.
- W3197775189 creator A5020653551 @default.
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- W3197775189 creator A5053981602 @default.
- W3197775189 creator A5056430981 @default.
- W3197775189 creator A5075523334 @default.
- W3197775189 date "2022-03-01" @default.
- W3197775189 modified "2023-10-18" @default.
- W3197775189 title "Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications" @default.
- W3197775189 cites W1483553420 @default.
- W3197775189 cites W1493971026 @default.
- W3197775189 cites W1505675828 @default.
- W3197775189 cites W1555774609 @default.
- W3197775189 cites W1572091120 @default.
- W3197775189 cites W1580333814 @default.
- W3197775189 cites W1596389679 @default.
- W3197775189 cites W1675525438 @default.
- W3197775189 cites W1865602869 @default.
- W3197775189 cites W1882650718 @default.
- W3197775189 cites W1911849097 @default.
- W3197775189 cites W1913730804 @default.
- W3197775189 cites W1919528470 @default.
- W3197775189 cites W1964842286 @default.
- W3197775189 cites W1966033287 @default.
- W3197775189 cites W1966582616 @default.
- W3197775189 cites W1966973099 @default.
- W3197775189 cites W1967094568 @default.
- W3197775189 cites W1967514197 @default.
- W3197775189 cites W1969546360 @default.
- W3197775189 cites W1970110620 @default.
- W3197775189 cites W1972531835 @default.
- W3197775189 cites W1972587570 @default.
- W3197775189 cites W1973098476 @default.
- W3197775189 cites W1973866760 @default.
- W3197775189 cites W1974030744 @default.
- W3197775189 cites W1974275522 @default.
- W3197775189 cites W1975781920 @default.
- W3197775189 cites W1975809633 @default.
- W3197775189 cites W1976184013 @default.
- W3197775189 cites W1976866228 @default.
- W3197775189 cites W1977107801 @default.
- W3197775189 cites W1977307022 @default.
- W3197775189 cites W1977782677 @default.
- W3197775189 cites W1978444132 @default.
- W3197775189 cites W1983798804 @default.
- W3197775189 cites W1984222509 @default.
- W3197775189 cites W1984697057 @default.
- W3197775189 cites W1984698010 @default.
- W3197775189 cites W1986772755 @default.
- W3197775189 cites W1988852963 @default.
- W3197775189 cites W1991565364 @default.
- W3197775189 cites W1992303064 @default.
- W3197775189 cites W1992948466 @default.
- W3197775189 cites W1993132387 @default.
- W3197775189 cites W1993269907 @default.
- W3197775189 cites W1993362870 @default.
- W3197775189 cites W1993596487 @default.
- W3197775189 cites W1994112667 @default.
- W3197775189 cites W1994170520 @default.
- W3197775189 cites W1994305178 @default.
- W3197775189 cites W1996344640 @default.
- W3197775189 cites W1996713062 @default.
- W3197775189 cites W1996821192 @default.
- W3197775189 cites W1997978122 @default.
- W3197775189 cites W1998288051 @default.
- W3197775189 cites W1998365263 @default.
- W3197775189 cites W1998435692 @default.
- W3197775189 cites W1998855918 @default.
- W3197775189 cites W1999666678 @default.
- W3197775189 cites W2000756775 @default.
- W3197775189 cites W2002072388 @default.
- W3197775189 cites W2002937742 @default.
- W3197775189 cites W2003040070 @default.
- W3197775189 cites W2003574906 @default.
- W3197775189 cites W2003652844 @default.
- W3197775189 cites W2004519092 @default.
- W3197775189 cites W2007789422 @default.
- W3197775189 cites W2008632158 @default.
- W3197775189 cites W2010133778 @default.
- W3197775189 cites W2010577443 @default.
- W3197775189 cites W2010993941 @default.
- W3197775189 cites W2012038857 @default.
- W3197775189 cites W2012619772 @default.
- W3197775189 cites W2013101928 @default.
- W3197775189 cites W2014260661 @default.
- W3197775189 cites W2014649168 @default.
- W3197775189 cites W2015497750 @default.
- W3197775189 cites W2015862047 @default.
- W3197775189 cites W2016261339 @default.
- W3197775189 cites W2016318825 @default.
- W3197775189 cites W2017011351 @default.
- W3197775189 cites W2017153527 @default.
- W3197775189 cites W2017457148 @default.
- W3197775189 cites W2019210320 @default.
- W3197775189 cites W2019582654 @default.
- W3197775189 cites W2019964412 @default.