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• W3197776013 startingPage "934" @default.
• W3197776013 abstract "Virulent bacterial viruses, also known as phages or bacteriophages, are considered as a potential option to fight antibiotic-resistant bacteria. However, their biology is still poorly understood, and only a fraction of phage genes is assigned with a function. To enable the first classification, we explored new options to test phage genes for their requirement on viral replication. As a model, we used the smallest known Bacillus subtilis phage Goe1, and the Cas9-based mutagenesis vector pRH030 as a genetic tool. All phage genes were specifically disrupted, and individual survival rates and mutant genotypes were investigated. Surviving phages relied on the genome integrity through host intrinsic non-homologues end joining system or a natural alteration of the Cas9 target sequence. Quantification of phage survivors and verifying the underlying genetic situation enables the classification of genes in essential or non-essential sets for viral replication. We also observed structural genes to hold more natural mutations than genes of the genome replication machinery." @default.
• W3197776013 created "2021-09-13" @default.
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• W3197776013 date "2021-08-31" @default.
• W3197776013 modified "2023-10-05" @default.
• W3197776013 title "Chances and limitations when uncovering essential and non‐essential genes of <scp><i>Bacillus subtilis</i></scp> phages with <scp>CRISPR‐Cas9</scp>" @default.
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• W3197776013 doi "https://doi.org/10.1111/1758-2229.13005" @default.
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