FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197777305> ?p ?o ?g. }

• W3197777305 endingPage "65" @default.
• W3197777305 startingPage "51" @default.
• W3197777305 abstract "Long noncoding RNAs (lncRNAs) play important roles in various biological activities as vital regulators. However, no study has focused on the lncRNA regulation of Outer membrane protein (OMP) immunization against aquatic bacterial infection. In this study, we examined the genome-wide expression of lncRNAs in the liver of European eel (Anguilla anguilla, Aa) administrated by a recombinant OmpA (rOmpA) from Edwardsiella anguillarum (Ea) to elucidate the functions of lncRNAs in the process of Ea infection and Aa anti-Ea infection using strand specific RNA-seq. Eels were challenged by Ea at 28 d post the immunization (dpi) of OmpA, and the result showed, compared to uninfected livers in the PBS group (Con group), the infected livers in the PBS group (Con_inf group) showed severe bleeding, hepatocyte atrophy and thrombi formed in the hepatic vessels; livers in the OmpA group (OmpA_inf) also formed slight thrombi in the hepatic vessels. The relative percent survival of eels in OmpA_inf vs Con_inf was 78.6%. Using high-throughput transcriptomics, we found 13405 lncRNAs in 3 compares of Con_inf vs Con, OmpA_inf vs Con and OmpA_inf vs Con_inf, of which 111, 129 and 158 DE-lncRNAs were ascertained. GO analysis of the DE-lncRNAs revealed the targeting DEGs were mainly involved in single-organism process, signaling, biological process and response to stimulus in BP, component of membrane in CC and binding in MF; KEGG pathways showed that the targeting DEGs in co-expression and co-location enriched in cell adhesion molecules. Finally, 54 DE-lncRNAs targeting 1675 DEGs were involved in an interaction network of 21692 co-expression and 483 co-location related links, of which 18 DE-lncRNAs appear to play crucial roles in anti-Ea infection. Thus, the interaction networks revealed crucial DE-lncRNAs underlying the process of Ea infection and Aa anti-Ea infection pre and post the immunization of OmpA." @default.
• W3197777305 created "2021-09-13" @default.
• W3197777305 creator A5016456430 @default.
• W3197777305 creator A5040477131 @default.
• W3197777305 creator A5071964473 @default.
• W3197777305 creator A5088619239 @default.
• W3197777305 date "2021-11-01" @default.
• W3197777305 modified "2023-10-18" @default.
• W3197777305 title "Transcriptome RNA-seq revealed lncRNAs activated by Edwardsiella anguillarum post the immunization of OmpA protecting European eel (Anguilla anguilla) from being infected" @default.
• W3197777305 cites W1769200113 @default.
• W3197777305 cites W1950287943 @default.
• W3197777305 cites W2021837286 @default.
• W3197777305 cites W2056358454 @default.
• W3197777305 cites W2059611232 @default.
• W3197777305 cites W2062502437 @default.
• W3197777305 cites W2072282717 @default.
• W3197777305 cites W2072314446 @default.
• W3197777305 cites W2073272879 @default.
• W3197777305 cites W2076102528 @default.
• W3197777305 cites W2096465161 @default.
• W3197777305 cites W2104005232 @default.
• W3197777305 cites W2107060225 @default.
• W3197777305 cites W2107872185 @default.
• W3197777305 cites W2113403474 @default.
• W3197777305 cites W2126953416 @default.
• W3197777305 cites W2145527616 @default.
• W3197777305 cites W2155769759 @default.
• W3197777305 cites W2335029242 @default.
• W3197777305 cites W2345246794 @default.
• W3197777305 cites W2360473132 @default.
• W3197777305 cites W2405688533 @default.
• W3197777305 cites W2583877249 @default.
• W3197777305 cites W2612724210 @default.
• W3197777305 cites W2736344634 @default.
• W3197777305 cites W2738237731 @default.
• W3197777305 cites W2746759026 @default.
• W3197777305 cites W2748921954 @default.
• W3197777305 cites W2767301359 @default.
• W3197777305 cites W2784570320 @default.
• W3197777305 cites W2797285543 @default.
• W3197777305 cites W2801718245 @default.
• W3197777305 cites W2884374296 @default.
• W3197777305 cites W2888655258 @default.
• W3197777305 cites W2893896755 @default.
• W3197777305 cites W2895679848 @default.
• W3197777305 cites W2896331764 @default.
• W3197777305 cites W2904924328 @default.
• W3197777305 cites W2912421956 @default.
• W3197777305 cites W2914057808 @default.
• W3197777305 cites W2923067435 @default.
• W3197777305 cites W2950985970 @default.
• W3197777305 cites W2957545617 @default.
• W3197777305 cites W2968832864 @default.
• W3197777305 cites W2968959073 @default.
• W3197777305 cites W2971451528 @default.
• W3197777305 cites W2971937244 @default.
• W3197777305 cites W2972458883 @default.
• W3197777305 cites W2979438587 @default.
• W3197777305 cites W2995777602 @default.
• W3197777305 cites W3000093690 @default.
• W3197777305 cites W3038381272 @default.
• W3197777305 cites W3047017455 @default.
• W3197777305 cites W3095155658 @default.
• W3197777305 cites W3096503116 @default.
• W3197777305 cites W3133195619 @default.
• W3197777305 cites W3144630207 @default.
• W3197777305 cites W3032140636 @default.
• W3197777305 doi "https://doi.org/10.1016/j.fsi.2021.08.027" @default.
• W3197777305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34474148" @default.
• W3197777305 hasPublicationYear "2021" @default.
• W3197777305 type Work @default.
• W3197777305 sameAs 3197777305 @default.
• W3197777305 citedByCount "11" @default.
• W3197777305 countsByYear W31977773052021 @default.
• W3197777305 countsByYear W31977773052022 @default.
• W3197777305 countsByYear W31977773052023 @default.
• W3197777305 crossrefType "journal-article" @default.
• W3197777305 hasAuthorship W3197777305A5016456430 @default.
• W3197777305 hasAuthorship W3197777305A5040477131 @default.
• W3197777305 hasAuthorship W3197777305A5071964473 @default.
• W3197777305 hasAuthorship W3197777305A5088619239 @default.
• W3197777305 hasConcept C104317684 @default.
• W3197777305 hasConcept C107397762 @default.
• W3197777305 hasConcept C147483822 @default.
• W3197777305 hasConcept C150194340 @default.
• W3197777305 hasConcept C153911025 @default.
• W3197777305 hasConcept C162317418 @default.
• W3197777305 hasConcept C203014093 @default.
• W3197777305 hasConcept C2776154503 @default.
• W3197777305 hasConcept C2780868878 @default.
• W3197777305 hasConcept C2781348184 @default.
• W3197777305 hasConcept C40767141 @default.
• W3197777305 hasConcept C523546767 @default.
• W3197777305 hasConcept C54355233 @default.
• W3197777305 hasConcept C55493867 @default.
• W3197777305 hasConcept C86803240 @default.
• W3197777305 hasConcept C89423630 @default.
• W3197777305 hasConcept C95444343 @default.

• next