Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197803178> ?p ?o ?g. }
- W3197803178 abstract "Cell polarity and morphogenesis are regulated by the small GTPase Cdc42. Even though major advances have been done in the field during the last years, the molecular details leading to its activation in particular cellular contexts are not completely understood. In fission yeast, the β(1,3)-glucanase Eng2 is a moonlighting protein with a dual function, acting as a hydrolase during spore dehiscence, and as component of the endocytic machinery in vegetative cells. Here, we report that Eng2 plays a role in Cdc42 activation during polarized growth through its interaction with the scaffold protein Scd2, which brings Cdc42 together with its guanine nucleotide exchange factor (GEF) Scd1. eng2Δ mutant cells have defects in activation of the bipolar growth (NETO), remaining monopolar during all the cell cycle. In the absence of Eng2 the accumulation of Scd1 and Scd2 at the poles is reduced, the levels of Cdc42 activation decrease, and the Cdc42 oscillatory behavior, associated with bipolar growth in wild type cells, is altered. Furthermore, overexpression of Eng2 partially rescues the growth and polarity defects of a cdc42-L160S mutant. Altogether, our work unveils a new factor regulating the activity of Cdc42, which could potentially link the polarity and endocytic machineries." @default.
- W3197803178 created "2021-09-13" @default.
- W3197803178 creator A5008156596 @default.
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- W3197803178 date "2021-09-09" @default.
- W3197803178 modified "2023-10-18" @default.
- W3197803178 title "Eng2, a new player involved in feedback loop regulation of Cdc42 activity in fission yeast" @default.
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- W3197803178 doi "https://doi.org/10.1038/s41598-021-97311-6" @default.
- W3197803178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8429772" @default.
- W3197803178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34504165" @default.
- W3197803178 hasPublicationYear "2021" @default.
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