FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197841206> ?p ?o ?g. }

• W3197841206 endingPage "4515" @default.
• W3197841206 startingPage "4515" @default.
• W3197841206 abstract "Male breast cancer (MBC) is a rare and understudied disease compared with female BC. About 15% of MBCs are associated with germline mutation in BC susceptibility genes, mainly BRCA1/2 and PALB2. Hereditary MBCs are likely to represent a subgroup of tumors with a peculiar phenotype. Here, we performed a whole transcriptome analysis of MBCs characterized for germline mutations in the most relevant BC susceptibility genes in order to identify molecular subtypes with clinical relevance. A series of 63 MBCs, including 16 BRCA2, 6 BRCA1, 2 PALB2, 1 RAD50, and 1 RAD51D germline-mutated cases, was analyzed by RNA-sequencing. Differential expression and hierarchical clustering analyses were performed. Module signatures associated with central biological processes involved in breast cancer pathogenesis were also examined. Different transcriptome profiles for genes mainly involved in the cell cycle, DNA damage, and DNA repair pathways emerged between MBCs with and without germline mutations. Unsupervised clustering analysis revealed two distinct subgroups, one of which was characterized by a higher expression of immune response genes, high scores of gene-expression signatures suggestive of aggressive behavior, and worse overall survival. Our results suggest that transcriptome matched with germline profiling may be a valuable approach for the identification and characterization of MBC subtypes with possible relevance in the clinical setting." @default.
• W3197841206 created "2021-09-13" @default.
• W3197841206 creator A5013727905 @default.
• W3197841206 creator A5016371744 @default.
• W3197841206 creator A5022153428 @default.
• W3197841206 creator A5029496632 @default.
• W3197841206 creator A5030791431 @default.
• W3197841206 creator A5044213949 @default.
• W3197841206 creator A5053450445 @default.
• W3197841206 creator A5058796036 @default.
• W3197841206 creator A5064532620 @default.
• W3197841206 creator A5066309419 @default.
• W3197841206 creator A5069078162 @default.
• W3197841206 creator A5075370584 @default.
• W3197841206 creator A5076681540 @default.
• W3197841206 creator A5083758770 @default.
• W3197841206 creator A5087146615 @default.
• W3197841206 creator A5088505960 @default.
• W3197841206 date "2021-09-08" @default.
• W3197841206 modified "2023-09-27" @default.
• W3197841206 title "Transcriptome of Male Breast Cancer Matched with Germline Profiling Reveals Novel Molecular Subtypes with Possible Clinical Relevance" @default.
• W3197841206 cites W1952488157 @default.
• W3197841206 cites W2003769907 @default.
• W3197841206 cites W2017558877 @default.
• W3197841206 cites W2043181232 @default.
• W3197841206 cites W2054611369 @default.
• W3197841206 cites W2064641822 @default.
• W3197841206 cites W2080661875 @default.
• W3197841206 cites W2094506222 @default.
• W3197841206 cites W2097015349 @default.
• W3197841206 cites W2104335176 @default.
• W3197841206 cites W2104558660 @default.
• W3197841206 cites W2104635744 @default.
• W3197841206 cites W2124640147 @default.
• W3197841206 cites W2133707124 @default.
• W3197841206 cites W2168664217 @default.
• W3197841206 cites W2264885989 @default.
• W3197841206 cites W2473570120 @default.
• W3197841206 cites W2508115611 @default.
• W3197841206 cites W2561130337 @default.
• W3197841206 cites W2562940941 @default.
• W3197841206 cites W2585352231 @default.
• W3197841206 cites W2592908133 @default.
• W3197841206 cites W2599226151 @default.
• W3197841206 cites W2781910129 @default.
• W3197841206 cites W2782703997 @default.
• W3197841206 cites W2801309958 @default.
• W3197841206 cites W2801425937 @default.
• W3197841206 cites W2808444757 @default.
• W3197841206 cites W2888076114 @default.
• W3197841206 cites W2893465708 @default.
• W3197841206 cites W2908723623 @default.
• W3197841206 cites W2963966788 @default.
• W3197841206 cites W3006424097 @default.
• W3197841206 cites W3016983055 @default.
• W3197841206 cites W3186622353 @default.
• W3197841206 doi "https://doi.org/10.3390/cancers13184515" @default.
• W3197841206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8469418" @default.
• W3197841206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34572741" @default.
• W3197841206 hasPublicationYear "2021" @default.
• W3197841206 type Work @default.
• W3197841206 sameAs 3197841206 @default.
• W3197841206 citedByCount "2" @default.
• W3197841206 countsByYear W31978412062023 @default.
• W3197841206 crossrefType "journal-article" @default.
• W3197841206 hasAuthorship W3197841206A5013727905 @default.
• W3197841206 hasAuthorship W3197841206A5016371744 @default.
• W3197841206 hasAuthorship W3197841206A5022153428 @default.
• W3197841206 hasAuthorship W3197841206A5029496632 @default.
• W3197841206 hasAuthorship W3197841206A5030791431 @default.
• W3197841206 hasAuthorship W3197841206A5044213949 @default.
• W3197841206 hasAuthorship W3197841206A5053450445 @default.
• W3197841206 hasAuthorship W3197841206A5058796036 @default.
• W3197841206 hasAuthorship W3197841206A5064532620 @default.
• W3197841206 hasAuthorship W3197841206A5066309419 @default.
• W3197841206 hasAuthorship W3197841206A5069078162 @default.
• W3197841206 hasAuthorship W3197841206A5075370584 @default.
• W3197841206 hasAuthorship W3197841206A5076681540 @default.
• W3197841206 hasAuthorship W3197841206A5083758770 @default.
• W3197841206 hasAuthorship W3197841206A5087146615 @default.
• W3197841206 hasAuthorship W3197841206A5088505960 @default.
• W3197841206 hasBestOaLocation W31978412061 @default.
• W3197841206 hasConcept C104317684 @default.
• W3197841206 hasConcept C109825262 @default.
• W3197841206 hasConcept C121608353 @default.
• W3197841206 hasConcept C13514818 @default.
• W3197841206 hasConcept C150194340 @default.
• W3197841206 hasConcept C162317418 @default.
• W3197841206 hasConcept C18431079 @default.
• W3197841206 hasConcept C2778144015 @default.
• W3197841206 hasConcept C501734568 @default.
• W3197841206 hasConcept C530470458 @default.
• W3197841206 hasConcept C54355233 @default.
• W3197841206 hasConcept C70721500 @default.
• W3197841206 hasConcept C86803240 @default.
• W3197841206 hasConceptScore W3197841206C104317684 @default.
• W3197841206 hasConceptScore W3197841206C109825262 @default.
• W3197841206 hasConceptScore W3197841206C121608353 @default.

• next