FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197858900> ?p ?o ?g. }

• W3197858900 endingPage "105317" @default.
• W3197858900 startingPage "105317" @default.
• W3197858900 abstract "KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme (Cathepsin L) currently in preclinical trials for the treatment of metastatic cancer, which is a leading cause of cancer-associated death. Herein, we report two new synthetic routes for synthesizing the target compound through four consecutive steps, using a Weinreb amide approach starting from a common 3-bromobenzoyl chloride. A key step in the approach is a coupling reaction of a readily available Grignard reagent with amide 4 to produce 6, a previously unreported coupling pattern. These new strategies offer an efficient and alternative approach to synthesis of target compound with an excellent overall yield." @default.
• W3197858900 created "2021-09-13" @default.
• W3197858900 creator A5000466447 @default.
• W3197858900 creator A5035236868 @default.
• W3197858900 creator A5041441266 @default.
• W3197858900 creator A5075116238 @default.
• W3197858900 creator A5078236748 @default.
• W3197858900 date "2021-11-01" @default.
• W3197858900 modified "2023-09-23" @default.
• W3197858900 title "An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94" @default.
• W3197858900 cites W1964184761 @default.
• W3197858900 cites W1964904964 @default.
• W3197858900 cites W1985805200 @default.
• W3197858900 cites W1998369345 @default.
• W3197858900 cites W2003321764 @default.
• W3197858900 cites W2011195302 @default.
• W3197858900 cites W2021202244 @default.
• W3197858900 cites W2026340265 @default.
• W3197858900 cites W2028935677 @default.
• W3197858900 cites W2031552376 @default.
• W3197858900 cites W2031879930 @default.
• W3197858900 cites W2041726318 @default.
• W3197858900 cites W2047501610 @default.
• W3197858900 cites W2054407653 @default.
• W3197858900 cites W2068023718 @default.
• W3197858900 cites W2069144597 @default.
• W3197858900 cites W2073946406 @default.
• W3197858900 cites W2076540449 @default.
• W3197858900 cites W2088978926 @default.
• W3197858900 cites W2093663953 @default.
• W3197858900 cites W2094024327 @default.
• W3197858900 cites W2094871139 @default.
• W3197858900 cites W2128206806 @default.
• W3197858900 cites W2171744625 @default.
• W3197858900 cites W2317142852 @default.
• W3197858900 cites W2318283418 @default.
• W3197858900 cites W2564416689 @default.
• W3197858900 cites W2952907500 @default.
• W3197858900 cites W3005131311 @default.
• W3197858900 cites W3091816375 @default.
• W3197858900 doi "https://doi.org/10.1016/j.bioorg.2021.105317" @default.
• W3197858900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34488126" @default.
• W3197858900 hasPublicationYear "2021" @default.
• W3197858900 type Work @default.
• W3197858900 sameAs 3197858900 @default.
• W3197858900 citedByCount "1" @default.
• W3197858900 countsByYear W31978589002023 @default.
• W3197858900 crossrefType "journal-article" @default.
• W3197858900 hasAuthorship W3197858900A5000466447 @default.
• W3197858900 hasAuthorship W3197858900A5035236868 @default.
• W3197858900 hasAuthorship W3197858900A5041441266 @default.
• W3197858900 hasAuthorship W3197858900A5075116238 @default.
• W3197858900 hasAuthorship W3197858900A5078236748 @default.
• W3197858900 hasConcept C134121241 @default.
• W3197858900 hasConcept C161624437 @default.
• W3197858900 hasConcept C167844969 @default.
• W3197858900 hasConcept C178790620 @default.
• W3197858900 hasConcept C181199279 @default.
• W3197858900 hasConcept C185592680 @default.
• W3197858900 hasConcept C191897082 @default.
• W3197858900 hasConcept C192562407 @default.
• W3197858900 hasConcept C21951064 @default.
• W3197858900 hasConcept C2777774944 @default.
• W3197858900 hasConcept C2778439535 @default.
• W3197858900 hasConcept C2779281246 @default.
• W3197858900 hasConcept C40875361 @default.
• W3197858900 hasConcept C55493867 @default.
• W3197858900 hasConcept C71240020 @default.
• W3197858900 hasConceptScore W3197858900C134121241 @default.
• W3197858900 hasConceptScore W3197858900C161624437 @default.
• W3197858900 hasConceptScore W3197858900C167844969 @default.
• W3197858900 hasConceptScore W3197858900C178790620 @default.
• W3197858900 hasConceptScore W3197858900C181199279 @default.
• W3197858900 hasConceptScore W3197858900C185592680 @default.
• W3197858900 hasConceptScore W3197858900C191897082 @default.
• W3197858900 hasConceptScore W3197858900C192562407 @default.
• W3197858900 hasConceptScore W3197858900C21951064 @default.
• W3197858900 hasConceptScore W3197858900C2777774944 @default.
• W3197858900 hasConceptScore W3197858900C2778439535 @default.
• W3197858900 hasConceptScore W3197858900C2779281246 @default.
• W3197858900 hasConceptScore W3197858900C40875361 @default.
• W3197858900 hasConceptScore W3197858900C55493867 @default.
• W3197858900 hasConceptScore W3197858900C71240020 @default.
• W3197858900 hasLocation W31978589001 @default.
• W3197858900 hasLocation W31978589002 @default.
• W3197858900 hasOpenAccess W3197858900 @default.
• W3197858900 hasPrimaryLocation W31978589001 @default.
• W3197858900 hasRelatedWork W1991636608 @default.
• W3197858900 hasRelatedWork W1999074229 @default.
• W3197858900 hasRelatedWork W2005248465 @default.
• W3197858900 hasRelatedWork W2034021897 @default.
• W3197858900 hasRelatedWork W2037846750 @default.
• W3197858900 hasRelatedWork W2391873203 @default.
• W3197858900 hasRelatedWork W2413520336 @default.
• W3197858900 hasRelatedWork W2949184651 @default.
• W3197858900 hasRelatedWork W2951785550 @default.
• W3197858900 hasRelatedWork W3197858900 @default.
• W3197858900 hasVolume "116" @default.

• next