FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197872615> ?p ?o ?g. }

• W3197872615 endingPage "9216" @default.
• W3197872615 startingPage "9198" @default.
• W3197872615 abstract "Small extracellular vesicles (sEVs) operate as a signaling platform due to their ability to carry functional molecular cargos. However, the role of sEVs in hypoxic tumor microenvironment-mediated premetastatic niche formation remains poorly understood. Methods: Protein expression profile of sEVs derived from normoxic and hypoxic head and neck squamous cell carcinoma (HNSCC) cells were determined by Isobaric Tagging Technology for Relative Quantitation. In vitro invasion assay and in vivo colonization were performed to evaluate the role of sEV-delivering proteins. Results: We identified lysyl oxidase like 2 (LOXL2) which had the highest fold increase in hypoxic sEVs compared with normoxic sEVs. Hypoxic cell-derived sEVs delivered high amounts of LOXL2 to non-hypoxic HNSCC cells to elicit epithelial-to-mesenchymal transition (EMT) and induce the invasion of the recipient cancer cells. Moreover, LOXL2-enriched sEVs were incorporated by distant fibroblasts and activate FAK/Src signaling in recipient fibroblasts. Increased production of fibronectin mediated by FAK/Src signaling recruited myeloid-derived suppressor cells to form a premetastatic niche. Serum sEV LOXL2 can reflect a hypoxic and aggressive tumor type and can serve as an alternative to tissue LOXL2 as an independent prognostic factor of overall survival for patients with HNSCC. Conclusion: sEVs derived from the hypoxic tumor microenvironment of HNSCC can drive local invasion of non-hypoxic HNSCC cells and stimulate premetastatic niche formation by delivering LOXL2 to non-hypoxic HNSCC cells and fibroblasts to induce EMT and fibronectin production, respectively." @default.
• W3197872615 created "2021-09-13" @default.
• W3197872615 creator A5000700564 @default.
• W3197872615 creator A5002325550 @default.
• W3197872615 creator A5004928583 @default.
• W3197872615 creator A5019707913 @default.
• W3197872615 creator A5025494303 @default.
• W3197872615 creator A5046096648 @default.
• W3197872615 creator A5052593664 @default.
• W3197872615 creator A5072861069 @default.
• W3197872615 creator A5077399002 @default.
• W3197872615 creator A5080308825 @default.
• W3197872615 creator A5083930055 @default.
• W3197872615 creator A5091230191 @default.
• W3197872615 date "2021-01-01" @default.
• W3197872615 modified "2023-09-30" @default.
• W3197872615 title "LOXL2-enriched small extracellular vesicles mediate hypoxia-induced premetastatic niche and indicates poor outcome of head and neck cancer" @default.
• W3197872615 cites W1493048246 @default.
• W3197872615 cites W1502521862 @default.
• W3197872615 cites W1516650929 @default.
• W3197872615 cites W1601681275 @default.
• W3197872615 cites W1950118853 @default.
• W3197872615 cites W1983953288 @default.
• W3197872615 cites W2002355437 @default.
• W3197872615 cites W2007226924 @default.
• W3197872615 cites W2010821717 @default.
• W3197872615 cites W2016081624 @default.
• W3197872615 cites W2020404158 @default.
• W3197872615 cites W2022551564 @default.
• W3197872615 cites W2040140079 @default.
• W3197872615 cites W2054077259 @default.
• W3197872615 cites W2065799167 @default.
• W3197872615 cites W2066722284 @default.
• W3197872615 cites W2081617614 @default.
• W3197872615 cites W2091068407 @default.
• W3197872615 cites W2098364791 @default.
• W3197872615 cites W2116000203 @default.
• W3197872615 cites W2117692326 @default.
• W3197872615 cites W2125915625 @default.
• W3197872615 cites W2127842409 @default.
• W3197872615 cites W2146530991 @default.
• W3197872615 cites W2147504123 @default.
• W3197872615 cites W2151029652 @default.
• W3197872615 cites W2157813647 @default.
• W3197872615 cites W2161031052 @default.
• W3197872615 cites W2163889800 @default.
• W3197872615 cites W2173706466 @default.
• W3197872615 cites W2301890235 @default.
• W3197872615 cites W2482783327 @default.
• W3197872615 cites W2552872119 @default.
• W3197872615 cites W2557222435 @default.
• W3197872615 cites W2570946556 @default.
• W3197872615 cites W2596133050 @default.
• W3197872615 cites W2604541426 @default.
• W3197872615 cites W2608168866 @default.
• W3197872615 cites W2750370897 @default.
• W3197872615 cites W2770151606 @default.
• W3197872615 cites W2792201438 @default.
• W3197872615 cites W2802799856 @default.
• W3197872615 cites W2849197408 @default.
• W3197872615 cites W2904628185 @default.
• W3197872615 cites W2928665623 @default.
• W3197872615 cites W2933960973 @default.
• W3197872615 cites W2941505882 @default.
• W3197872615 cites W2946172068 @default.
• W3197872615 cites W2946977580 @default.
• W3197872615 cites W2967997773 @default.
• W3197872615 cites W2980926947 @default.
• W3197872615 cites W2991409283 @default.
• W3197872615 cites W3000429196 @default.
• W3197872615 cites W3038472266 @default.
• W3197872615 cites W3133313832 @default.
• W3197872615 cites W576850159 @default.
• W3197872615 cites W3021664385 @default.
• W3197872615 doi "https://doi.org/10.7150/thno.62455" @default.
• W3197872615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8490529" @default.
• W3197872615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34646366" @default.
• W3197872615 hasPublicationYear "2021" @default.
• W3197872615 type Work @default.
• W3197872615 sameAs 3197872615 @default.
• W3197872615 citedByCount "14" @default.
• W3197872615 countsByYear W31978726152021 @default.
• W3197872615 countsByYear W31978726152022 @default.
• W3197872615 countsByYear W31978726152023 @default.
• W3197872615 crossrefType "journal-article" @default.
• W3197872615 hasAuthorship W3197872615A5000700564 @default.
• W3197872615 hasAuthorship W3197872615A5002325550 @default.
• W3197872615 hasAuthorship W3197872615A5004928583 @default.
• W3197872615 hasAuthorship W3197872615A5019707913 @default.
• W3197872615 hasAuthorship W3197872615A5025494303 @default.
• W3197872615 hasAuthorship W3197872615A5046096648 @default.
• W3197872615 hasAuthorship W3197872615A5052593664 @default.
• W3197872615 hasAuthorship W3197872615A5072861069 @default.
• W3197872615 hasAuthorship W3197872615A5077399002 @default.
• W3197872615 hasAuthorship W3197872615A5080308825 @default.
• W3197872615 hasAuthorship W3197872615A5083930055 @default.
• W3197872615 hasAuthorship W3197872615A5091230191 @default.
• W3197872615 hasBestOaLocation W31978726151 @default.

• next