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- W3197874518 abstract "Survival for children and young adults with T-cell acute lymphoblastic leukemia (T-ALL) has improved remarkably over the past 50 years. While 5-year overall survival (OS) exceeds 85% for newly diagnosed patients, the majority of patients with relapsed and refractory (R/R) T-ALL are not curable (3-year OS <30%).1,2 Thus, the primary goal in the treatment of T-ALL is to prevent relapse. The improvement in outcomes has historically been achieved by carefully designed sequential randomized clinical trials performed by multiple cooperative groups.3–8 With intensified T-ALL-focused therapy, survival for de novo T-ALL patients is now similar to that of B-ALL. Unfortunately, the further intensification of cytotoxic therapy is not feasible because of treatment-related mortality. Two approaches that have the potential to improve cure rates are more accurate risk stratification and the incorporation of effective novel therapies. Survival for children and young adults with T-cell acute lymphoblastic leukemia (T-ALL) has improved remarkably over the past 50 years. While 5-year overall survival (OS) exceeds 85% for newly diagnosed patients, the majority of patients with relapsed and refractory (R/R) T-ALL are not curable (3-year OS <30%).1,2 Thus, the primary goal in the treatment of T-ALL is to prevent relapse. The improvement in outcomes has historically been achieved by carefully designed sequential randomized clinical trials performed by multiple cooperative groups.3–8 With intensified T-ALL-focused therapy, survival for de novo T-ALL patients is now similar to that of B-ALL. Unfortunately, the further intensification of cytotoxic therapy is not feasible because of treatment-related mortality. Two approaches that have the potential to improve cure rates are more accurate risk stratification and the incorporation of effective novel therapies." @default.
- W3197874518 created "2021-09-13" @default.
- W3197874518 creator A5028647628 @default.
- W3197874518 date "2021-09-01" @default.
- W3197874518 modified "2023-09-23" @default.
- W3197874518 title "Novel Approaches to T-Cell ALL" @default.
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- W3197874518 doi "https://doi.org/10.1016/s2152-2650(21)01225-8" @default.
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