FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197881036> ?p ?o ?g. }

• W3197881036 endingPage "209" @default.
• W3197881036 startingPage "199" @default.
• W3197881036 abstract "Extrahepatic metastasis from hepatocellular carcinoma (HCC) is a catastrophic event, yet organ-specific pathological characteristics of metastatic HCC remain unclear. We aimed to characterize the pathological aspects of HCC metastases to various organs.We collected intrahepatic HCC (cohort 1, n = 322) and extrahepatic metastatic HCC (cohort 2, n = 130) samples. Clinicopathological evaluation and immunostaining for K19, CD34, αSMA, fibroblast-associated protein (FAP), CAIX, VEGF, PD-L1, CD3, CD8, Foxp3, CD163 and epithelial-mesenchymal transition (EMT)-related markers were performed.Independent factors for extrahepatic metastasis included BCLC stage B-C, microvascular invasion (MVI), vessels encapsulating tumour clusters (VETC)-HCC, K19 and FAP expression, and CD163+ macrophage infiltration (cohort 1, P < .05 for all). Lung metastases (n = 63) had the highest proportion of VETC-HCC and macrotrabecular-massive (MTM)-HCC. Lymph node metastases (n = 19) showed significantly high rates of EMT-high features, K19 expression, fibrous tumour stroma with αSMA and FAP expression, high immune cell infiltration, PD-L1 expression (combined positive score), CD3+, CD8+, Foxp3+ T cell and CD163+ macrophage infiltration (adjusted P < .05 for all). In both cohorts, EMT-high HCCs showed higher rates of K19 expression, fibrous tumour stroma, high immune cell infiltration, PD-L1 expression and CD3+ T cell infiltration, whereas EMT-low HCCs were more frequent among VETC-HCCs (P < .05 for all). Overall phenotypic features were not significantly different between paired primary-metastatic HCCs (n = 32).Metastatic HCCs to various organs showed different pathological features. VETC and MTM subtypes were related to lung metastasis, whereas K19 expression, EMT-high features with fibrous tumour stroma and high immune cell infiltration were related to lymph node metastasis." @default.
• W3197881036 created "2021-09-13" @default.
• W3197881036 creator A5023720694 @default.
• W3197881036 creator A5031544855 @default.
• W3197881036 creator A5033232203 @default.
• W3197881036 creator A5054417741 @default.
• W3197881036 creator A5064614797 @default.
• W3197881036 creator A5065963667 @default.
• W3197881036 creator A5066261910 @default.
• W3197881036 creator A5070772179 @default.
• W3197881036 creator A5088966151 @default.
• W3197881036 date "2021-09-15" @default.
• W3197881036 modified "2023-10-17" @default.
• W3197881036 title "Lung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects" @default.
• W3197881036 cites W1520425169 @default.
• W3197881036 cites W1587807025 @default.
• W3197881036 cites W1922647212 @default.
• W3197881036 cites W1965856669 @default.
• W3197881036 cites W1969607893 @default.
• W3197881036 cites W1977161163 @default.
• W3197881036 cites W2003938487 @default.
• W3197881036 cites W2011022187 @default.
• W3197881036 cites W2014260136 @default.
• W3197881036 cites W2055894717 @default.
• W3197881036 cites W2095075235 @default.
• W3197881036 cites W2100070712 @default.
• W3197881036 cites W2100891986 @default.
• W3197881036 cites W2103512612 @default.
• W3197881036 cites W2104271563 @default.
• W3197881036 cites W2111788806 @default.
• W3197881036 cites W2123065898 @default.
• W3197881036 cites W2124653487 @default.
• W3197881036 cites W2128446760 @default.
• W3197881036 cites W2132240483 @default.
• W3197881036 cites W2133503086 @default.
• W3197881036 cites W2143270794 @default.
• W3197881036 cites W2145990138 @default.
• W3197881036 cites W2147302324 @default.
• W3197881036 cites W2499029168 @default.
• W3197881036 cites W2598230851 @default.
• W3197881036 cites W2606765235 @default.
• W3197881036 cites W2612910794 @default.
• W3197881036 cites W2621577071 @default.
• W3197881036 cites W2766985996 @default.
• W3197881036 cites W2780918397 @default.
• W3197881036 cites W2789461790 @default.
• W3197881036 cites W2888600337 @default.
• W3197881036 cites W2889801069 @default.
• W3197881036 cites W2899783716 @default.
• W3197881036 cites W2903509048 @default.
• W3197881036 cites W2915960039 @default.
• W3197881036 cites W2950312587 @default.
• W3197881036 cites W2952311394 @default.
• W3197881036 cites W2966691789 @default.
• W3197881036 cites W2977722669 @default.
• W3197881036 cites W2990602950 @default.
• W3197881036 cites W3000291746 @default.
• W3197881036 cites W3012360622 @default.
• W3197881036 cites W3162744466 @default.
• W3197881036 doi "https://doi.org/10.1111/liv.15051" @default.
• W3197881036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34490997" @default.
• W3197881036 hasPublicationYear "2021" @default.
• W3197881036 type Work @default.
• W3197881036 sameAs 3197881036 @default.
• W3197881036 citedByCount "15" @default.
• W3197881036 countsByYear W31978810362021 @default.
• W3197881036 countsByYear W31978810362022 @default.
• W3197881036 countsByYear W31978810362023 @default.
• W3197881036 crossrefType "journal-article" @default.
• W3197881036 hasAuthorship W3197881036A5023720694 @default.
• W3197881036 hasAuthorship W3197881036A5031544855 @default.
• W3197881036 hasAuthorship W3197881036A5033232203 @default.
• W3197881036 hasAuthorship W3197881036A5054417741 @default.
• W3197881036 hasAuthorship W3197881036A5064614797 @default.
• W3197881036 hasAuthorship W3197881036A5065963667 @default.
• W3197881036 hasAuthorship W3197881036A5066261910 @default.
• W3197881036 hasAuthorship W3197881036A5070772179 @default.
• W3197881036 hasAuthorship W3197881036A5088966151 @default.
• W3197881036 hasConcept C121608353 @default.
• W3197881036 hasConcept C126322002 @default.
• W3197881036 hasConcept C142724271 @default.
• W3197881036 hasConcept C202751555 @default.
• W3197881036 hasConcept C204232928 @default.
• W3197881036 hasConcept C2775858924 @default.
• W3197881036 hasConcept C2778019345 @default.
• W3197881036 hasConcept C2779013556 @default.
• W3197881036 hasConcept C2779244956 @default.
• W3197881036 hasConcept C2779314089 @default.
• W3197881036 hasConcept C2780849966 @default.
• W3197881036 hasConcept C502942594 @default.
• W3197881036 hasConcept C55493867 @default.
• W3197881036 hasConcept C71924100 @default.
• W3197881036 hasConcept C86803240 @default.
• W3197881036 hasConceptScore W3197881036C121608353 @default.
• W3197881036 hasConceptScore W3197881036C126322002 @default.
• W3197881036 hasConceptScore W3197881036C142724271 @default.
• W3197881036 hasConceptScore W3197881036C202751555 @default.
• W3197881036 hasConceptScore W3197881036C204232928 @default.

• next