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- W3197934765 abstract "Essential thrombocythemia (ET) is a clonal disorder of a multipotent hematopoietic progenitor cell. In most patients, a driving mutation of Janus kinase 2 gene, calreticulin gene or myeloproliferative leukemia virus oncogene is detected. The occurrence of thrombotic and/or bleeding complications is very typical in manifestations of ET, with many cases of both occurring in the same patient. The thrombotic or bleeding phenotype can be a consequence of the coexistence of driving and non-driving molecular mutations and polymorphisms, affecting the platelet number and function. This paper discusses the nature of this disease, paying special attention to calreticulin gene function." @default.
- W3197934765 created "2021-09-13" @default.
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- W3197934765 date "2021-01-01" @default.
- W3197934765 modified "2023-09-25" @default.
- W3197934765 title "Calreticulin, a multi-faceted protein: thrombotic and bleeding risks in CALR mutation positive essential thrombocythemiaa" @default.
- W3197934765 doi "https://doi.org/10.5603/ahp.2021.0055" @default.
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