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• W3197979991 endingPage "6280" @default.
• W3197979991 startingPage "6270" @default.
• W3197979991 abstract "Licochalcone A (Lico A) is a natural flavonoid belonging to the class of substituted chalcone that has various biological effects. Mast cells (MCs) are innate immune cells that mediate hypersensitivity and pseudo-allergic reactions. MAS-related GPR family member X2 (MRGPRX2) on MCs has been recognized as the main receptor for pseudo-allergic reactions. In this study, we investigated the anti-pseudo-allergy effect of Lico A and its underlying mechanism. Substance P (SP), as an MC activator, was used to establish an in vitro and in vivo model of pseudo-allergy. The in vivo effect of Lico A was investigated using passive cutaneous anaphylaxis (PCA) and active systemic allergy, along with degranulation, Ca2+ influx in vitro. SP-induced laboratory of allergic disease 2 (LAD2) cell mRNA expression was explored using RNA-seq, and Lico A inhibited LAD2 cell activation by reverse transcription polymerase chain reaction (RT-PCR), western blotting, and immunofluorescence staining. Lico A showed an inhibitory effect on SP-induced MC activation and pseudo-allergy both in vitro and in vivo. The nuclear factor (NF)-κB pathway is involved in MRGPRX2 induced MC activation, which is inhibited by Lico A. In conclusion, Lico A inhibited the pseudo-allergic reaction mediated by MRGPRX2 by blocking NF-κB nuclear migration." @default.
• W3197979991 created "2021-09-13" @default.
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• W3197979991 date "2021-09-05" @default.
• W3197979991 modified "2023-09-25" @default.
• W3197979991 title "Licochalcone A inhibits <scp>MAS</scp> ‐related <scp>GPR</scp> family member <scp>X2</scp> ‐induced pseudo‐allergic reaction by suppressing nuclear migration of nuclear <scp>factor‐κB</scp>" @default.
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• W3197979991 doi "https://doi.org/10.1002/ptr.7272" @default.
• W3197979991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34486187" @default.
• W3197979991 hasPublicationYear "2021" @default.
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