Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197981064> ?p ?o ?g. }
- W3197981064 endingPage "1083" @default.
- W3197981064 startingPage "1074" @default.
- W3197981064 abstract "Recombinant therapeutic proteins are a broad class of biological products used to replace dysfunctional human proteins in individuals with genetic defects (e.g., factor VIII for hemophilia) or, in the case of monoclonal antibodies, bind to disease targets involved in cancers, autoimmune disorders, or other conditions. Unfortunately, immunogenicity (immune response to the drug) remains a key impediment, potentially affecting the safety and efficacy of these therapeutics. Immunogenicity risk is routinely evaluated during the licensure of therapeutic proteins. However, despite eliciting anti-drug immune responses in at least some patients, most protein drugs are nevertheless licensed as they address unmet medical needs. The pre-licensure immunogenicity assessments of therapeutic proteins are the subject of numerous reviews and white papers. However, observation and clinical management of the immunogenicity of approved therapeutic proteins face additional challenges. We survey the immunogenicity of approved therapeutic proteins, discuss the clinical management of immunogenicity, and identify the challenges to establishing clinically relevant immunogenicity assays for use in routine clinical practice." @default.
- W3197981064 created "2021-09-13" @default.
- W3197981064 creator A5002820920 @default.
- W3197981064 creator A5003551399 @default.
- W3197981064 creator A5091041425 @default.
- W3197981064 date "2021-11-01" @default.
- W3197981064 modified "2023-09-26" @default.
- W3197981064 title "Secondary failure: immune responses to approved protein therapeutics" @default.
- W3197981064 cites W1513454528 @default.
- W3197981064 cites W1776223521 @default.
- W3197981064 cites W1915598702 @default.
- W3197981064 cites W1964146287 @default.
- W3197981064 cites W1967295501 @default.
- W3197981064 cites W1970875728 @default.
- W3197981064 cites W1997999969 @default.
- W3197981064 cites W1998614164 @default.
- W3197981064 cites W2000835442 @default.
- W3197981064 cites W2001943408 @default.
- W3197981064 cites W2008531871 @default.
- W3197981064 cites W2008639498 @default.
- W3197981064 cites W2012027479 @default.
- W3197981064 cites W2015731791 @default.
- W3197981064 cites W2018146163 @default.
- W3197981064 cites W2020589546 @default.
- W3197981064 cites W2023604859 @default.
- W3197981064 cites W2032868562 @default.
- W3197981064 cites W2035578076 @default.
- W3197981064 cites W2044160586 @default.
- W3197981064 cites W2047150424 @default.
- W3197981064 cites W2050941564 @default.
- W3197981064 cites W2055655054 @default.
- W3197981064 cites W2069102446 @default.
- W3197981064 cites W2069506532 @default.
- W3197981064 cites W2071634485 @default.
- W3197981064 cites W2076454500 @default.
- W3197981064 cites W2088517709 @default.
- W3197981064 cites W2090723639 @default.
- W3197981064 cites W2091858933 @default.
- W3197981064 cites W2094992193 @default.
- W3197981064 cites W2098837289 @default.
- W3197981064 cites W2099289539 @default.
- W3197981064 cites W2100199292 @default.
- W3197981064 cites W2102087425 @default.
- W3197981064 cites W2103667265 @default.
- W3197981064 cites W2105311242 @default.
- W3197981064 cites W2115969391 @default.
- W3197981064 cites W2118580564 @default.
- W3197981064 cites W2138572955 @default.
- W3197981064 cites W2153097869 @default.
- W3197981064 cites W2156250460 @default.
- W3197981064 cites W2167801052 @default.
- W3197981064 cites W2168814191 @default.
- W3197981064 cites W2321453230 @default.
- W3197981064 cites W2326330820 @default.
- W3197981064 cites W2586724023 @default.
- W3197981064 cites W2623521568 @default.
- W3197981064 cites W2746547351 @default.
- W3197981064 cites W2759307758 @default.
- W3197981064 cites W2784524664 @default.
- W3197981064 cites W2799781194 @default.
- W3197981064 cites W2808509820 @default.
- W3197981064 cites W2885678144 @default.
- W3197981064 cites W2897546361 @default.
- W3197981064 cites W2917928050 @default.
- W3197981064 cites W2940078382 @default.
- W3197981064 cites W2941891017 @default.
- W3197981064 cites W2978880955 @default.
- W3197981064 cites W2981758958 @default.
- W3197981064 cites W2990678510 @default.
- W3197981064 cites W2996699059 @default.
- W3197981064 cites W3015232330 @default.
- W3197981064 cites W3039467801 @default.
- W3197981064 cites W3048134729 @default.
- W3197981064 cites W3095158811 @default.
- W3197981064 cites W3154133691 @default.
- W3197981064 cites W3157292130 @default.
- W3197981064 cites W4296259680 @default.
- W3197981064 doi "https://doi.org/10.1016/j.molmed.2021.08.003" @default.
- W3197981064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34493437" @default.
- W3197981064 hasPublicationYear "2021" @default.
- W3197981064 type Work @default.
- W3197981064 sameAs 3197981064 @default.
- W3197981064 citedByCount "7" @default.
- W3197981064 countsByYear W31979810642022 @default.
- W3197981064 countsByYear W31979810642023 @default.
- W3197981064 crossrefType "journal-article" @default.
- W3197981064 hasAuthorship W3197981064A5002820920 @default.
- W3197981064 hasAuthorship W3197981064A5003551399 @default.
- W3197981064 hasAuthorship W3197981064A5091041425 @default.
- W3197981064 hasConcept C126322002 @default.
- W3197981064 hasConcept C159110408 @default.
- W3197981064 hasConcept C203014093 @default.
- W3197981064 hasConcept C2780035454 @default.
- W3197981064 hasConcept C2780868878 @default.
- W3197981064 hasConcept C2781234862 @default.
- W3197981064 hasConcept C535046627 @default.
- W3197981064 hasConcept C71924100 @default.
- W3197981064 hasConcept C8891405 @default.