Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197996170> ?p ?o ?g. }
- W3197996170 abstract "Newcastle disease virus (NDV) has caused significant outbreaks in South-East Asia, particularly in Indonesia in recent years. Recently emerged genotype VII NDVs (NDV-GVII) have shifted their tropism from gastrointestinal/respiratory tropism to a lymphotropic virus, invading lymphoid organs including spleen and bursa of Fabricius to cause profound lymphoid depletion. In this study, we aimed to identify candidate genes and biological pathways that contribute to the disease caused by this velogenic NDV-GVII. A transcriptomic analysis based on RNA-Seq of spleen was performed in chickens challenged with NDV-GVII and a control group. In total, 6361 genes were differentially expressed that included 3506 up-regulated genes and 2855 down-regulated genes. Real-Time PCR of ten selected genes validated the RNA-Seq results as the correlation between them is 0.98. Functional and network analysis of Differentially Expressed Genes (DEGs) showed altered regulation of ElF2 signalling, mTOR signalling, proliferation of cells of the lymphoid system, signalling by Rho family GTPases and synaptogenesis signalling in spleen. We have also identified modified expression of IFIT5, PI3K, AGT and PLP1 genes in NDV-GVII infected chickens. Our findings in activation of autophagy-mediated cell death, lymphotropic and synaptogenesis signalling pathways provide new insights into the molecular pathogenesis of this newly emerged NDV-GVII." @default.
- W3197996170 created "2021-09-13" @default.
- W3197996170 creator A5004283184 @default.
- W3197996170 creator A5011277474 @default.
- W3197996170 creator A5022175957 @default.
- W3197996170 creator A5039002603 @default.
- W3197996170 creator A5066376171 @default.
- W3197996170 creator A5078813951 @default.
- W3197996170 creator A5086957287 @default.
- W3197996170 creator A5088211647 @default.
- W3197996170 date "2021-09-02" @default.
- W3197996170 modified "2023-10-18" @default.
- W3197996170 title "Indicators of the molecular pathogenesis of virulent Newcastle disease virus in chickens revealed by transcriptomic profiling of spleen" @default.
- W3197996170 cites W1654044795 @default.
- W3197996170 cites W1797474275 @default.
- W3197996170 cites W1884516068 @default.
- W3197996170 cites W1963874911 @default.
- W3197996170 cites W1963889744 @default.
- W3197996170 cites W1976457497 @default.
- W3197996170 cites W1976751873 @default.
- W3197996170 cites W1981021081 @default.
- W3197996170 cites W1982022798 @default.
- W3197996170 cites W1986173321 @default.
- W3197996170 cites W1987344954 @default.
- W3197996170 cites W1989482679 @default.
- W3197996170 cites W1993648099 @default.
- W3197996170 cites W1999772306 @default.
- W3197996170 cites W2001815108 @default.
- W3197996170 cites W2001991267 @default.
- W3197996170 cites W2007117114 @default.
- W3197996170 cites W2008545186 @default.
- W3197996170 cites W2025000087 @default.
- W3197996170 cites W2027434548 @default.
- W3197996170 cites W2028842451 @default.
- W3197996170 cites W2029058633 @default.
- W3197996170 cites W2030869676 @default.
- W3197996170 cites W2039023491 @default.
- W3197996170 cites W2044818544 @default.
- W3197996170 cites W2059904733 @default.
- W3197996170 cites W2064876347 @default.
- W3197996170 cites W2068165412 @default.
- W3197996170 cites W2082359960 @default.
- W3197996170 cites W2082597722 @default.
- W3197996170 cites W2092242297 @default.
- W3197996170 cites W2092640638 @default.
- W3197996170 cites W2095004167 @default.
- W3197996170 cites W2102162973 @default.
- W3197996170 cites W2102278945 @default.
- W3197996170 cites W2107018762 @default.
- W3197996170 cites W2108234281 @default.
- W3197996170 cites W2115034937 @default.
- W3197996170 cites W2121608531 @default.
- W3197996170 cites W2126784042 @default.
- W3197996170 cites W2128255145 @default.
- W3197996170 cites W2129356204 @default.
- W3197996170 cites W2131750052 @default.
- W3197996170 cites W2138207763 @default.
- W3197996170 cites W2138581811 @default.
- W3197996170 cites W2140228548 @default.
- W3197996170 cites W2141803727 @default.
- W3197996170 cites W2142923098 @default.
- W3197996170 cites W2146046197 @default.
- W3197996170 cites W2146512944 @default.
- W3197996170 cites W2157319729 @default.
- W3197996170 cites W2157625936 @default.
- W3197996170 cites W2158440702 @default.
- W3197996170 cites W2161725688 @default.
- W3197996170 cites W2162143298 @default.
- W3197996170 cites W2162193190 @default.
- W3197996170 cites W2167017590 @default.
- W3197996170 cites W2167203210 @default.
- W3197996170 cites W2177270532 @default.
- W3197996170 cites W2263582186 @default.
- W3197996170 cites W2331863554 @default.
- W3197996170 cites W234950505 @default.
- W3197996170 cites W2523531978 @default.
- W3197996170 cites W2597047694 @default.
- W3197996170 cites W2599920979 @default.
- W3197996170 cites W2765659208 @default.
- W3197996170 cites W2777680002 @default.
- W3197996170 cites W2788640168 @default.
- W3197996170 cites W2791498814 @default.
- W3197996170 cites W2795364721 @default.
- W3197996170 cites W2805302945 @default.
- W3197996170 cites W2890070691 @default.
- W3197996170 cites W2892351445 @default.
- W3197996170 cites W2903326534 @default.
- W3197996170 cites W2952357306 @default.
- W3197996170 cites W2952746913 @default.
- W3197996170 cites W2991347447 @default.
- W3197996170 cites W299500345 @default.
- W3197996170 cites W3004749503 @default.
- W3197996170 cites W3033087879 @default.
- W3197996170 cites W3033401942 @default.
- W3197996170 cites W3035372479 @default.
- W3197996170 cites W3081325082 @default.
- W3197996170 cites W3087568645 @default.
- W3197996170 cites W3140383254 @default.
- W3197996170 cites W4231326085 @default.
- W3197996170 cites W926858313 @default.