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- W3197999746 abstract "In Alzheimer's disease, soluble oligomers of the amyloid-β peptide (Aβo) trigger a cascade of events that includes abnormal hyperphosphorylation of the protein tau, which is essential for pathogenesis. However, the mechanistic link between these two key pathological proteins remains unclear. Using hippocampal slices, we show here that an Aβo-mediated increase in glutamate release probability causes enhancement of synaptically evoked N-methyl-d-aspartate subtype glutamate receptor (NMDAR)-dependent long-term depression (LTD). We also find that elevated glutamate release probability is required for Aβo-induced pathological hyperphosphorylation of tau, which is likewise NMDAR dependent. Finally, we show that chronic, repeated chemical or optogenetic induction of NMDAR-dependent LTD alone is sufficient to cause tau hyperphosphorylation without Aβo. Together, these results support a possible causal chain in which Aβo increases glutamate release probability, thus leading to enhanced LTD induction, which in turn drives hyperphosphorylation of tau. Our data identify a mechanistic pathway linking the two critical pathogenic proteins of AD." @default.
- W3197999746 created "2021-09-13" @default.
- W3197999746 creator A5012664789 @default.
- W3197999746 creator A5085247343 @default.
- W3197999746 creator A5086791647 @default.
- W3197999746 date "2021-08-01" @default.
- W3197999746 modified "2023-10-17" @default.
- W3197999746 title "Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau" @default.
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- W3197999746 doi "https://doi.org/10.1016/j.celrep.2021.109638" @default.
- W3197999746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8424646" @default.
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- W3197999746 hasPublicationYear "2021" @default.
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