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- W3198005440 abstract "Alzheimer's disease (AD) has been considered a long-lasting, devastating public health concern due to a high folding increase in global aging percentage worldwide. Different approaches have been confined to cut down this high percentage of neurodegenerative disorder due to a lack of successful, efficient strategic protocol for AD treatment. One of these approaches is the transplantation or injection of mesenchymal stem cells (MSCs) due to their neuromodulatory, anti-inflammatory, and antioxidant actions. To elucidate and determine whether intravenous (IV) or intracerebroventricular (ICV) administration of MSCs is the most efficient and successful method in engulfing amyloid-β plaques and improving cognitive defects. The efficiency of MSCs was investigated on lipopolysaccharides (LPS) AD-induced rats. Thirty-two rats were randomly divided equally into four groups identified as a control group (C/G1), AD-induced group (AD/G2), intravenous AD-induced group (IV/G3), and ICV AD-induced group (ICV/G4). Amyloid-β, tau protein, tumor necrosis factor-α (TNF-α), interleukin (IL-10) were detected using the ELISA technique while MDA and GSH brain tissue level were detected colorimetry. The histopathological examination of different brain tissues demonstrated the presence of Aβ plaques following LPS induction. Administration of both types of MSCs into AD-induced rats resulted in a significant decrease in the brain's hallmarks depositions, oxidative stress, and inflammatory factors with different degrees and efficiency. The present study indicates the efficiency of both types of MSCs administration in improving AD subjects' cognitive defects with a more relevant efficiency following ICV administration, considering the risk to benefits ratio before taking inaction treatment initiation." @default.
- W3198005440 created "2021-09-13" @default.
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- W3198005440 date "2021-12-01" @default.
- W3198005440 modified "2023-09-27" @default.
- W3198005440 title "The therapeutic potential and efficiency of Intracerebroventricular transplantation and intravenous injection of Mesenchymal stem cells in relieving Aß hallmarks and improving cognitive dysfunction in AD induced model" @default.
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- W3198005440 doi "https://doi.org/10.1016/j.genrep.2021.101323" @default.
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