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- W3198013016 abstract "The devastating complications of coronavirus disease 2019 (COVID-19) result from an individual’s dysfunctional immune response following the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple toxic stressors and behaviors contribute to underlying immune system dysfunction. SARS-CoV-2 exploits the dysfunctional immune system to trigger a chain of events ultimately leading to COVID-19. We have previously identified many contributing factors (CFs) (representing toxic exposure, lifestyle factors and psychosocial stressors) common to myriad chronic diseases. We hypothesized significant overlap between CFs associated with COVID-19 and inflammatory bowel disease (IBD), because of the strong role immune dysfunction plays in each disease. A streamlined dot-product approach was used to identify potential CFs to COVID-19 and IBD. Of the fifty CFs to COVID-19 that were validated for demonstration purposes, approximately half had direct impact on COVID-19 (the CF and COVID-19 were mentioned in the same record; i.e., CF---→COVID-19), and the other half had indirect impact. The nascent character of the COVID-19 core literature (∼ one year old) did not allow sufficient time for the direct impacts of many CFs on COVID-19 to be identified. Therefore, an immune system dysfunction (ID) literature directly related to the COVID-19 core literature was used to augment the COVID-19 core literature and provide the remaining CFs that impacted COVID-19 indirectly (i.e., CF---→immune system dysfunction---→COVID-19). Approximately 13000 potential CFs for myriad diseases (obtained from government and university toxic substance lists) served as the starting point for the dot-product identification process. These phrases were intersected (dot-product) with phrases extracted from a PubMed-derived IBD core literature, a nascent COVID-19 core literature, and the COVID-19-related immune system dysfunction (ID) core literature to identify common ID/COVID-19 and IBD CFs. Approximately 3000 potential CFs common to both ID and IBD, almost 2300 potential CFs common to ID and COVID-19, and over 1900 potential CFs common to IBD and COVID-19 were identified. As proof of concept, we validated fifty of these ∼3000 overlapping ID/IBD candidate CFs with biologic plausibility. We further validated 24 of the fifty as common CFs in the IBD and nascent COVID-19 core literatures. This significant finding demonstrated that the CFs indirectly related to COVID-19 -- identified with use of the immune system dysfunction literature -- are strong candidates to emerge eventually as CFs directly related to COVID-19. As discussed in the main text, many more CFs common to all these core literatures could be identified and validated. ID and IBD share many common risk/contributing factors, including behaviors and toxic exposures that impair immune function. A key component to immune system health is removal of those factors that contribute to immune system dysfunction in the first place. This requires a paradigm shift from traditional Western medicine, which often focuses on treatment, rather than prevention." @default.
- W3198013016 created "2021-09-13" @default.
- W3198013016 creator A5019651281 @default.
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- W3198013016 creator A5077448841 @default.
- W3198013016 date "2021-01-01" @default.
- W3198013016 modified "2023-10-17" @default.
- W3198013016 title "Common contributing factors to COVID-19 and inflammatory bowel disease" @default.
- W3198013016 cites W1754402210 @default.
- W3198013016 cites W1898205741 @default.
- W3198013016 cites W1923658646 @default.
- W3198013016 cites W1949215044 @default.
- W3198013016 cites W1950981769 @default.
- W3198013016 cites W1975576130 @default.
- W3198013016 cites W1976199195 @default.
- W3198013016 cites W1989286613 @default.
- W3198013016 cites W1992629138 @default.
- W3198013016 cites W1993167689 @default.
- W3198013016 cites W1993355443 @default.
- W3198013016 cites W1997847158 @default.
- W3198013016 cites W2001096456 @default.
- W3198013016 cites W2007229925 @default.
- W3198013016 cites W2019326608 @default.
- W3198013016 cites W2027604422 @default.
- W3198013016 cites W2027775095 @default.
- W3198013016 cites W2028749374 @default.
- W3198013016 cites W2029170128 @default.
- W3198013016 cites W2030631780 @default.
- W3198013016 cites W2031220427 @default.
- W3198013016 cites W2031558979 @default.
- W3198013016 cites W2031696097 @default.
- W3198013016 cites W2033516986 @default.
- W3198013016 cites W2036897032 @default.
- W3198013016 cites W2037257630 @default.
- W3198013016 cites W2050855801 @default.
- W3198013016 cites W2050990078 @default.
- W3198013016 cites W2056910995 @default.
- W3198013016 cites W2062714235 @default.
- W3198013016 cites W2068112776 @default.
- W3198013016 cites W2075202322 @default.
- W3198013016 cites W2076357880 @default.
- W3198013016 cites W2077229808 @default.
- W3198013016 cites W2081362293 @default.
- W3198013016 cites W2087971582 @default.
- W3198013016 cites W2092438825 @default.
- W3198013016 cites W2092753808 @default.
- W3198013016 cites W2098899994 @default.
- W3198013016 cites W2099690490 @default.
- W3198013016 cites W2105327109 @default.
- W3198013016 cites W2124688365 @default.
- W3198013016 cites W2128571125 @default.
- W3198013016 cites W2133771865 @default.
- W3198013016 cites W2135750659 @default.
- W3198013016 cites W2137913257 @default.
- W3198013016 cites W2146499587 @default.
- W3198013016 cites W2147055478 @default.
- W3198013016 cites W2152336072 @default.
- W3198013016 cites W2154612703 @default.
- W3198013016 cites W2158684175 @default.
- W3198013016 cites W2171598959 @default.
- W3198013016 cites W2185232263 @default.
- W3198013016 cites W2196736345 @default.
- W3198013016 cites W2206465107 @default.
- W3198013016 cites W2234012279 @default.
- W3198013016 cites W2254841936 @default.
- W3198013016 cites W2267080217 @default.
- W3198013016 cites W2293027646 @default.
- W3198013016 cites W2293903172 @default.
- W3198013016 cites W2298284389 @default.
- W3198013016 cites W2319809815 @default.
- W3198013016 cites W2397419958 @default.
- W3198013016 cites W2398393547 @default.
- W3198013016 cites W2475290162 @default.
- W3198013016 cites W2505706005 @default.
- W3198013016 cites W2507447343 @default.
- W3198013016 cites W2522844236 @default.
- W3198013016 cites W2546525035 @default.
- W3198013016 cites W2580339406 @default.
- W3198013016 cites W2585384567 @default.
- W3198013016 cites W2588565968 @default.
- W3198013016 cites W2592596430 @default.
- W3198013016 cites W2593076333 @default.
- W3198013016 cites W2594070031 @default.
- W3198013016 cites W2613996502 @default.
- W3198013016 cites W2657207019 @default.
- W3198013016 cites W2749425110 @default.
- W3198013016 cites W2766046358 @default.
- W3198013016 cites W2766883294 @default.
- W3198013016 cites W2771099855 @default.
- W3198013016 cites W2778655464 @default.
- W3198013016 cites W2782221164 @default.
- W3198013016 cites W2783494524 @default.
- W3198013016 cites W2785343910 @default.
- W3198013016 cites W2789519700 @default.