FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198018045> ?p ?o ?g. }

• W3198018045 abstract "After budding yeast cells cultured in a nutrient-rich liquid medium with glucose ferment glucose to ethanol and then consume it as a carbon source, they enter the stationary phase of culturing and the process of their chronological aging begins. At that point, yeast cells in the culture arrest their cell cycle and enter a state of quiescence, also known as the G0 state. Shortly following such cell cycle arrest, the yeast culture begins to accumulate quiescent and non-quiescent cells. The Titorenko laboratory has recently used gradient centrifugation to purify the high- and low-density sub-populations quiescent and non-quiescent cells. They demonstrated that caloricrestriction, a robust aging-delaying (geroprotective) dietary intervention, decreases the concentrations of the neutral storage lipids triacylglycerols and increases the concentration of the mitochondrial membrane lipid cardiolipin in quiescent and non-quiescent cells. The studies described in my Thesis had the following two objectives. First, I sought to investigate how caloric restriction influences the concentrations of all lipid classes (not only triacylglycerols and cardiolipin concentrations) within the high- and low-density sub-populations of quiescent and nonquiescent yeast cells on different stages of the chronological aging process. My second objective was to compare the effects of caloric restriction, the tor1Δ mutation (a genetic geroprotective intervention) and lithocholic acid (a pharmacological geroprotective intervention) on the lipidomesof the high- and low-density sub-populations of quiescent and non-quiescent yeast cells on different stages of chronological aging. To attain these objectives, I used liquid chromatographycoupled with tandem mass spectrometry quantitative lipidomics to assess the aging-associated changes in high- and low-density cells’ lipidomes. I provided the first evidence that caloricrestriction statistically significantly alters the concentrations of 18 different lipid classes through most of the chronological lifespan of high- and low-density cells. Caloric restriction decreased triacylglycerol concentration, increased free fatty acid concentration, raised ceramide concentration, and elevated phospholipid concentrations in high- and low-density cells through most of the chronological lifespan. My data also provided the first evidence that caloric restriction creates lipidomic patterns of chronologically aging high- and low-density cells that differ from the lipidomic patterns of these cells established by the tor1Δ mutation and lithocholic acid." @default.
• W3198018045 created "2021-09-13" @default.
• W3198018045 creator A5032873667 @default.
• W3198018045 date "2021-03-03" @default.
• W3198018045 modified "2023-09-27" @default.
• W3198018045 title "Caloric Restriction Causes a Distinct Remodeling of the Lipidome in Quiescent Cells of Budding Yeast" @default.
• W3198018045 cites W126695622 @default.
• W3198018045 cites W1593284523 @default.
• W3198018045 cites W1614045200 @default.
• W3198018045 cites W1992814112 @default.
• W3198018045 cites W1993777075 @default.
• W3198018045 cites W2004399350 @default.
• W3198018045 cites W2042646789 @default.
• W3198018045 cites W2051509673 @default.
• W3198018045 cites W2067820742 @default.
• W3198018045 cites W2080433494 @default.
• W3198018045 cites W2109134015 @default.
• W3198018045 cites W2124591765 @default.
• W3198018045 cites W2126338409 @default.
• W3198018045 cites W2153974854 @default.
• W3198018045 cites W2157513547 @default.
• W3198018045 cites W2160238206 @default.
• W3198018045 cites W2162023120 @default.
• W3198018045 cites W2597811559 @default.
• W3198018045 cites W2727065253 @default.
• W3198018045 cites W2750598473 @default.
• W3198018045 cites W2883231068 @default.
• W3198018045 cites W2896909185 @default.
• W3198018045 cites W2899277631 @default.
• W3198018045 cites W2906988746 @default.
• W3198018045 cites W2937901070 @default.
• W3198018045 cites W3009642700 @default.
• W3198018045 cites W569634410 @default.
• W3198018045 hasPublicationYear "2021" @default.
• W3198018045 type Work @default.
• W3198018045 sameAs 3198018045 @default.
• W3198018045 citedByCount "0" @default.
• W3198018045 crossrefType "dissertation" @default.
• W3198018045 hasAuthorship W3198018045A5032873667 @default.
• W3198018045 hasConcept C185592680 @default.
• W3198018045 hasConcept C2777576037 @default.
• W3198018045 hasConcept C2778918659 @default.
• W3198018045 hasConcept C2779222958 @default.
• W3198018045 hasConcept C2780241833 @default.
• W3198018045 hasConcept C2781302388 @default.
• W3198018045 hasConcept C41625074 @default.
• W3198018045 hasConcept C55493867 @default.
• W3198018045 hasConcept C58017582 @default.
• W3198018045 hasConcept C86803240 @default.
• W3198018045 hasConcept C95444343 @default.
• W3198018045 hasConceptScore W3198018045C185592680 @default.
• W3198018045 hasConceptScore W3198018045C2777576037 @default.
• W3198018045 hasConceptScore W3198018045C2778918659 @default.
• W3198018045 hasConceptScore W3198018045C2779222958 @default.
• W3198018045 hasConceptScore W3198018045C2780241833 @default.
• W3198018045 hasConceptScore W3198018045C2781302388 @default.
• W3198018045 hasConceptScore W3198018045C41625074 @default.
• W3198018045 hasConceptScore W3198018045C55493867 @default.
• W3198018045 hasConceptScore W3198018045C58017582 @default.
• W3198018045 hasConceptScore W3198018045C86803240 @default.
• W3198018045 hasConceptScore W3198018045C95444343 @default.
• W3198018045 hasLocation W31980180451 @default.
• W3198018045 hasOpenAccess W3198018045 @default.
• W3198018045 hasPrimaryLocation W31980180451 @default.
• W3198018045 hasRelatedWork W1974899316 @default.
• W3198018045 hasRelatedWork W2031106264 @default.
• W3198018045 hasRelatedWork W2036444413 @default.
• W3198018045 hasRelatedWork W2089676382 @default.
• W3198018045 hasRelatedWork W2115344427 @default.
• W3198018045 hasRelatedWork W2463964093 @default.
• W3198018045 hasRelatedWork W2909174322 @default.
• W3198018045 hasRelatedWork W3004469825 @default.
• W3198018045 hasRelatedWork W3157841831 @default.
• W3198018045 hasRelatedWork W76267410 @default.
• W3198018045 isParatext "false" @default.
• W3198018045 isRetracted "false" @default.
• W3198018045 magId "3198018045" @default.
• W3198018045 workType "dissertation" @default.