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• W3198021708 abstract "We formulate and theoretically analyze a mathematical model of COVID-19 transmission mechanism incorporating vital dynamics of the disease and two key therapeutic measures—vaccination of susceptible individuals and recovery/treatment of infected individuals. Both the disease-free and endemic equilibrium are globally asymptotically stable when the effective reproduction number <math xmlns=http://www.w3.org/1998/Math/MathML id=M1><msub><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow></msub><mfenced open=( close=)><mrow><mi>v</mi></mrow></mfenced></math> is, respectively, less or greater than unity. The derived critical vaccination threshold is dependent on the vaccine efficacy for disease eradication whenever <math xmlns=http://www.w3.org/1998/Math/MathML id=M2><msub><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow></msub><mfenced open=( close=)><mrow><mi>v</mi></mrow></mfenced><mo>></mo><mn>1</mn></math> , even if vaccine coverage is high. Pontryagin’s maximum principle is applied to establish the existence of the optimal control problem and to derive the necessary conditions to optimally mitigate the spread of the disease. The model is fitted with cumulative daily Senegal data, with a basic reproduction number <math xmlns=http://www.w3.org/1998/Math/MathML id=M3><msub><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow></msub><mo>=</mo><mn>1.31</mn></math> at the onset of the epidemic. Simulation results suggest that despite the effectiveness of COVID-19 vaccination and treatment to mitigate the spread of COVID-19, when <math xmlns=http://www.w3.org/1998/Math/MathML id=M4><msub><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow></msub><mfenced open=( close=)><mrow><mi>v</mi></mrow></mfenced><mo>></mo><mn>1</mn></math> , additional efforts such as nonpharmaceutical public health interventions should continue to be implemented. Using partial rank correlation coefficients and Latin hypercube sampling, sensitivity analysis is carried out to determine the relative importance of model parameters to disease transmission. Results shown graphically could help to inform the process of prioritizing public health intervention measures to be implemented and which model parameter to focus on in order to mitigate the spread of the disease. The effective contact rate <math xmlns=http://www.w3.org/1998/Math/MathML id=M5><mi>b</mi></math> , the vaccine efficacy <math xmlns=http://www.w3.org/1998/Math/MathML id=M6><mi>ε</mi></math> , the vaccination rate <math xmlns=http://www.w3.org/1998/Math/MathML id=M7><mi>v</mi></math> , the fraction of exposed individuals who develop symptoms, and, respectively, the exit rates from the exposed and the asymptomatic classes <math xmlns=http://www.w3.org/1998/Math/MathML id=M8><mi>σ</mi></math> and <math xmlns=http://www.w3.org/1998/Math/MathML id=M9><mi>ϕ</mi></math> are the most impactful parameters." @default.
• W3198021708 created "2021-09-13" @default.
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• W3198021708 date "2021-09-04" @default.
• W3198021708 modified "2023-10-06" @default.
• W3198021708 title "A Mathematical Model of COVID-19 with Vaccination and Treatment" @default.
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• W3198021708 doi "https://doi.org/10.1155/2021/1250129" @default.
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