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- W3198022505 endingPage "4354" @default.
- W3198022505 startingPage "4354" @default.
- W3198022505 abstract "Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of human cancers. Clinical trials of various chemotherapy, radiotherapy, targeted agents and combination strategies have generally failed to provide meaningful improvement in survival for patients with unresectable disease. Photodynamic therapy (PDT) is a photochemistry-based approach that enables selective cell killing using tumor-localizing agents activated by visible or near-infrared light. In recent years, clinical studies have demonstrated the technical feasibility of PDT for patients with locally advanced PDAC while a growing body of preclinical literature has shown that PDT can overcome drug resistance and target problematic and aggressive disease. Emerging evidence also suggests the ability of PDT to target PDAC stroma, which is known to act as both a barrier to drug delivery and a tumor-promoting signaling partner. Here, we review the literature which indicates an emergent role of PDT in clinical management of PDAC, including the potential for combination with other targeted agents and RNA medicine." @default.
- W3198022505 created "2021-09-13" @default.
- W3198022505 creator A5001110260 @default.
- W3198022505 creator A5004594328 @default.
- W3198022505 creator A5013989133 @default.
- W3198022505 date "2021-08-28" @default.
- W3198022505 modified "2023-09-26" @default.
- W3198022505 title "Photodynamic Therapy for Pancreatic Ductal Adenocarcinoma" @default.
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