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- W3198113591 abstract "Inflammation is a central element of many neurodegenerative diseases. Formyl peptide receptors (FPRs) can trigger several receptor-dependent signal transduction pathways that play a key role in neuroinflammation and neurodegeneration. They are chemotactic receptors that help to regulate pro- and anti-inflammatory responses in most mammals. FPRs are primarily expressed in the immune and nervous systems where they interact with a complex pattern of pathogen-derived and host-endogenous molecules. Mounting evidence points towards a contribution of FPRs - via neuropathological ligands such as Amyloid beta, and neuroprotective ligands such as Humanin, Lipoxin A4, and Annexin A1 - to multiple pathological aspects of neurodegenerative diseases. In this review, we aim to summarize the interplay of FPRs with neuropathological and neuroprotective ligands. Next, we depict their capability to trigger a number of ligand-dependent cell signaling pathways and their potential to interact with additional intracellular cofactors. Moreover, we highlight first studies, demonstrating that a pharmacological inhibition of FPRs helps to ameliorate neuroinflammation, which may pave the way towards novel therapeutic strategies." @default.
- W3198113591 created "2021-09-13" @default.
- W3198113591 creator A5008865692 @default.
- W3198113591 creator A5051294768 @default.
- W3198113591 creator A5053279143 @default.
- W3198113591 creator A5066671595 @default.
- W3198113591 creator A5073529348 @default.
- W3198113591 date "2021-09-10" @default.
- W3198113591 modified "2023-10-03" @default.
- W3198113591 title "Emerging contributions of formyl peptide receptors to neurodegenerative diseases" @default.
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