Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198144413> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3198144413 endingPage "101463" @default.
- W3198144413 startingPage "101463" @default.
- W3198144413 abstract "The degree of HLA compatibility between donor and recipient in hematopoietic stem cell transplantation is critical. In this report, we describe an acute lymphoblastic leukemia case with loss of heterozygosity (LOH) encompassing the entire HLA.HLA molecular typing was performed on peripheral blood (PB) and buccal swabs (BS). Chromosomal microarray analysis (CMA) was performed using a whole genome platform.Typing results on PB sample collected during blast crisis demonstrated homozygosity at the-B,-C,-DR, and -DP loci. A BS sample demonstrated heterozygosity at the above loci. A subsequent PB sample drawn after count recovery confirmed heterozygosity. The CMA performed on PB samples collected during blast crisis revealed a large terminal region of copy-neutral LOH involving chromosome region 6p25.3p21.31, spanning approximately 33.32 Mb. The results of the CMA assay on sample collected after count recovery did not demonstrate LOH.LOH at the HLA gene locus may significantly influence the donor search resulting in mistakenly choosing homozygous donors. We recommend confirming the HLA typing of recipients with hematological malignancies when homozygosity is detected at any locus by using BS samples, or alternatively from PB when remission is achieved." @default.
- W3198144413 created "2021-09-13" @default.
- W3198144413 creator A5052971954 @default.
- W3198144413 creator A5065972775 @default.
- W3198144413 creator A5067347223 @default.
- W3198144413 creator A5086720717 @default.
- W3198144413 creator A5087851208 @default.
- W3198144413 date "2021-12-01" @default.
- W3198144413 modified "2023-10-10" @default.
- W3198144413 title "Pretransplant HLA mistyping in diagnostic sample of a T-ALL patient due to loss of heterozygosity in the major histocompatibility complex" @default.
- W3198144413 cites W1572267688 @default.
- W3198144413 cites W1997220089 @default.
- W3198144413 cites W2006254364 @default.
- W3198144413 cites W2027437991 @default.
- W3198144413 cites W2034657403 @default.
- W3198144413 cites W2038281957 @default.
- W3198144413 cites W2039234691 @default.
- W3198144413 cites W2039856043 @default.
- W3198144413 cites W2047711126 @default.
- W3198144413 cites W2073673847 @default.
- W3198144413 cites W2081265652 @default.
- W3198144413 cites W2096769034 @default.
- W3198144413 cites W2131587128 @default.
- W3198144413 cites W2161257907 @default.
- W3198144413 cites W2884254916 @default.
- W3198144413 cites W2961599785 @default.
- W3198144413 doi "https://doi.org/10.1016/j.trim.2021.101463" @default.
- W3198144413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34492296" @default.
- W3198144413 hasPublicationYear "2021" @default.
- W3198144413 type Work @default.
- W3198144413 sameAs 3198144413 @default.
- W3198144413 citedByCount "1" @default.
- W3198144413 countsByYear W31981444132022 @default.
- W3198144413 crossrefType "journal-article" @default.
- W3198144413 hasAuthorship W3198144413A5052971954 @default.
- W3198144413 hasAuthorship W3198144413A5065972775 @default.
- W3198144413 hasAuthorship W3198144413A5067347223 @default.
- W3198144413 hasAuthorship W3198144413A5086720717 @default.
- W3198144413 hasAuthorship W3198144413A5087851208 @default.
- W3198144413 hasConcept C104317684 @default.
- W3198144413 hasConcept C126322002 @default.
- W3198144413 hasConcept C143589142 @default.
- W3198144413 hasConcept C147483822 @default.
- W3198144413 hasConcept C180754005 @default.
- W3198144413 hasConcept C188280979 @default.
- W3198144413 hasConcept C2781209916 @default.
- W3198144413 hasConcept C2911091166 @default.
- W3198144413 hasConcept C54355233 @default.
- W3198144413 hasConcept C71924100 @default.
- W3198144413 hasConcept C84597430 @default.
- W3198144413 hasConcept C86803240 @default.
- W3198144413 hasConceptScore W3198144413C104317684 @default.
- W3198144413 hasConceptScore W3198144413C126322002 @default.
- W3198144413 hasConceptScore W3198144413C143589142 @default.
- W3198144413 hasConceptScore W3198144413C147483822 @default.
- W3198144413 hasConceptScore W3198144413C180754005 @default.
- W3198144413 hasConceptScore W3198144413C188280979 @default.
- W3198144413 hasConceptScore W3198144413C2781209916 @default.
- W3198144413 hasConceptScore W3198144413C2911091166 @default.
- W3198144413 hasConceptScore W3198144413C54355233 @default.
- W3198144413 hasConceptScore W3198144413C71924100 @default.
- W3198144413 hasConceptScore W3198144413C84597430 @default.
- W3198144413 hasConceptScore W3198144413C86803240 @default.
- W3198144413 hasLocation W31981444131 @default.
- W3198144413 hasLocation W31981444132 @default.
- W3198144413 hasOpenAccess W3198144413 @default.
- W3198144413 hasPrimaryLocation W31981444131 @default.
- W3198144413 hasRelatedWork W1965726430 @default.
- W3198144413 hasRelatedWork W1983574409 @default.
- W3198144413 hasRelatedWork W1995257130 @default.
- W3198144413 hasRelatedWork W2027506631 @default.
- W3198144413 hasRelatedWork W2125344851 @default.
- W3198144413 hasRelatedWork W2131839889 @default.
- W3198144413 hasRelatedWork W2157891295 @default.
- W3198144413 hasRelatedWork W2163650164 @default.
- W3198144413 hasRelatedWork W2384927114 @default.
- W3198144413 hasRelatedWork W2414907829 @default.
- W3198144413 hasVolume "69" @default.
- W3198144413 isParatext "false" @default.
- W3198144413 isRetracted "false" @default.
- W3198144413 magId "3198144413" @default.
- W3198144413 workType "article" @default.