FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198162947> ?p ?o ?g. }

• W3198162947 endingPage "114" @default.
• W3198162947 startingPage "104" @default.
• W3198162947 abstract "Brain magnetic resonance imaging studies have not investigated the cortical surface comprehensively in schizophrenia subjects by assessing thickness, surface area and gyrification separately during the first-episode of psychosis (FEP) or chronic schizophrenia (ChSch).We investigated cortical surface abnormalities in 137 FEP patients and 240 ChSch subjects compared to 297 Healthy Controls (HC) contributed by five cohorts. Maps showing results of vertexwise between-group comparisons of cortical thickness, area, and gyrification were produced using T1-weighted datasets processed using FreeSurfer 5.3, followed by validated quality control protocols.FEP subjects showed large clusters of increased area and gyrification relative to HC in prefrontal and insuli cortices (Cohen's d: 0.049 to 0.28). These between-group differences occurred partially beyond the effect of sample. ChSch subjects displayed reduced cortical thickness relative to HC in smaller fronto-temporal foci (d: -0.73 to -0.35), but not beyond the effect of sample. Differences between FEP and HC subjects were associated with male gender, younger age, and earlier illness onset, while differences between ChSch and HC were associated with treatment-resistance and first-generation antipsychotic (FGA) intake independently of sample effect.Separate assessments of FEP and ChSch revealed abnormalities that differed in regional distribution, phenotypes affected and effect size. In FEP, associations of greater cortical area and gyrification abnormalities with earlier age of onset suggest an origin on anomalous neurodevelopment, while thickness reductions in ChSch are at least partially explained by treatment-resistance and FGA intake. Associations of between-group differences with clinical variables retained statistical significance beyond the effect of sample." @default.
• W3198162947 created "2021-09-13" @default.
• W3198162947 creator A5012849944 @default.
• W3198162947 creator A5024706015 @default.
• W3198162947 creator A5028430186 @default.
• W3198162947 creator A5029245216 @default.
• W3198162947 creator A5031304910 @default.
• W3198162947 creator A5036025904 @default.
• W3198162947 creator A5048182376 @default.
• W3198162947 creator A5054036019 @default.
• W3198162947 creator A5064402249 @default.
• W3198162947 creator A5065125054 @default.
• W3198162947 creator A5067555000 @default.
• W3198162947 creator A5071932687 @default.
• W3198162947 creator A5072499049 @default.
• W3198162947 creator A5079145074 @default.
• W3198162947 creator A5081930990 @default.
• W3198162947 creator A5085753285 @default.
• W3198162947 creator A5088509319 @default.
• W3198162947 date "2021-10-01" @default.
• W3198162947 modified "2023-10-16" @default.
• W3198162947 title "Cortical surface abnormalities are different depending on the stage of schizophrenia: A cross-sectional vertexwise mega-analysis of thickness, area and gyrification" @default.
• W3198162947 cites W146572136 @default.
• W3198162947 cites W1894823067 @default.
• W3198162947 cites W1972097894 @default.
• W3198162947 cites W1975336801 @default.
• W3198162947 cites W1978997011 @default.
• W3198162947 cites W1985450019 @default.
• W3198162947 cites W1986760793 @default.
• W3198162947 cites W1988183526 @default.
• W3198162947 cites W1991448791 @default.
• W3198162947 cites W1996055441 @default.
• W3198162947 cites W2003800343 @default.
• W3198162947 cites W2004559917 @default.
• W3198162947 cites W2024805919 @default.
• W3198162947 cites W2025453479 @default.
• W3198162947 cites W2033540257 @default.
• W3198162947 cites W2061550384 @default.
• W3198162947 cites W2063176769 @default.
• W3198162947 cites W2068100452 @default.
• W3198162947 cites W2068384789 @default.
• W3198162947 cites W2069922847 @default.
• W3198162947 cites W2072860571 @default.
• W3198162947 cites W2089476693 @default.
• W3198162947 cites W2090200674 @default.
• W3198162947 cites W2093863882 @default.
• W3198162947 cites W2101135654 @default.
• W3198162947 cites W2107026277 @default.
• W3198162947 cites W2110208125 @default.
• W3198162947 cites W2110737377 @default.
• W3198162947 cites W2113319997 @default.
• W3198162947 cites W2118694870 @default.
• W3198162947 cites W2119195417 @default.
• W3198162947 cites W2123064933 @default.
• W3198162947 cites W2123412124 @default.
• W3198162947 cites W2126693856 @default.
• W3198162947 cites W2134266651 @default.
• W3198162947 cites W2138567287 @default.
• W3198162947 cites W2145240519 @default.
• W3198162947 cites W2147316388 @default.
• W3198162947 cites W2151721316 @default.
• W3198162947 cites W2156123885 @default.
• W3198162947 cites W2156833737 @default.
• W3198162947 cites W2165130903 @default.
• W3198162947 cites W2319655279 @default.
• W3198162947 cites W2419381113 @default.
• W3198162947 cites W2550462688 @default.
• W3198162947 cites W2605688447 @default.
• W3198162947 cites W2613067964 @default.
• W3198162947 cites W2614464346 @default.
• W3198162947 cites W2734718615 @default.
• W3198162947 cites W2748699180 @default.
• W3198162947 cites W2754094519 @default.
• W3198162947 cites W2776130467 @default.
• W3198162947 cites W2793681509 @default.
• W3198162947 cites W2804287612 @default.
• W3198162947 cites W2948155912 @default.
• W3198162947 cites W3035841897 @default.
• W3198162947 doi "https://doi.org/10.1016/j.schres.2021.08.011" @default.
• W3198162947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34481405" @default.
• W3198162947 hasPublicationYear "2021" @default.
• W3198162947 type Work @default.
• W3198162947 sameAs 3198162947 @default.
• W3198162947 citedByCount "8" @default.
• W3198162947 countsByYear W31981629472022 @default.
• W3198162947 countsByYear W31981629472023 @default.
• W3198162947 crossrefType "journal-article" @default.
• W3198162947 hasAuthorship W3198162947A5012849944 @default.
• W3198162947 hasAuthorship W3198162947A5024706015 @default.
• W3198162947 hasAuthorship W3198162947A5028430186 @default.
• W3198162947 hasAuthorship W3198162947A5029245216 @default.
• W3198162947 hasAuthorship W3198162947A5031304910 @default.
• W3198162947 hasAuthorship W3198162947A5036025904 @default.
• W3198162947 hasAuthorship W3198162947A5048182376 @default.
• W3198162947 hasAuthorship W3198162947A5054036019 @default.
• W3198162947 hasAuthorship W3198162947A5064402249 @default.
• W3198162947 hasAuthorship W3198162947A5065125054 @default.
• W3198162947 hasAuthorship W3198162947A5067555000 @default.

• next